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Psychological follow-up study of 5-year-old ICSI children.
Hum Reprod. 2004 Dec; 19(12):2791-7.HR

Abstract

BACKGROUND

The developmental outcomes of children born after ICSI are still a matter of concern. The purpose of the present study was to investigate psychological outcomes for 5-year-old children born after ICSI and compare these with outcomes for children born after spontaneous conception (SC).

METHODS

Three hundred singleton children born after ICSI in Belgium, Sweden and the USA were matched by maternal age, child age and gender. Outcome measures included the Wechsler Preschool and Primary scales of intelligence (WPPSI-R), Peabody Developmental Motor Scales, Parenting Stress Index and Child Behaviour Checklist.

RESULTS

Regarding cognitive development, no significant differences were found on WPPSI-R verbal and performance scales between ICSI and SC children. However, some differences were noted on subtests of the Performance Scale. ICSI children more often obtained a score below 1 SD of the mean on the subtests: Object Assembly, Block Design and Mazes (all P<0.05). Significant differences by site (i.e. Belgium, Sweden and New York) were found on subtests related to parenting stress, child behaviour problems and motor development (all P<0.05). These findings can probably be explained by variables other than conception mode, such as cultural differences and selection bias.

CONCLUSIONS

Although the finding that a higher proportion of ICSI children obtained scores below the cut-off on some of the visual-spatial subscales of the WPPSI-R warrants further investigation, ICSI does not appear to affect the psychological well-being or cognitive development at age 5.

Authors+Show Affiliations

Department of Developmental- and Lifespanpsychology, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium. ikristof@vub.ac.beNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15358721

Citation

Ponjaert-Kristoffersen, I, et al. "Psychological Follow-up Study of 5-year-old ICSI Children." Human Reproduction (Oxford, England), vol. 19, no. 12, 2004, pp. 2791-7.
Ponjaert-Kristoffersen I, Tjus T, Nekkebroeck J, et al. Psychological follow-up study of 5-year-old ICSI children. Hum Reprod. 2004;19(12):2791-7.
Ponjaert-Kristoffersen, I., Tjus, T., Nekkebroeck, J., Squires, J., Verté, D., Heimann, M., Bonduelle, M., Palermo, G., & Wennerholm, U. B. (2004). Psychological follow-up study of 5-year-old ICSI children. Human Reproduction (Oxford, England), 19(12), 2791-7.
Ponjaert-Kristoffersen I, et al. Psychological Follow-up Study of 5-year-old ICSI Children. Hum Reprod. 2004;19(12):2791-7. PubMed PMID: 15358721.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Psychological follow-up study of 5-year-old ICSI children. AU - Ponjaert-Kristoffersen,I, AU - Tjus,T, AU - Nekkebroeck,J, AU - Squires,J, AU - Verté,D, AU - Heimann,M, AU - Bonduelle,M, AU - Palermo,G, AU - Wennerholm,U-B, AU - ,, Y1 - 2004/09/09/ PY - 2004/9/11/pubmed PY - 2005/6/1/medline PY - 2004/9/11/entrez SP - 2791 EP - 7 JF - Human reproduction (Oxford, England) JO - Hum Reprod VL - 19 IS - 12 N2 - BACKGROUND: The developmental outcomes of children born after ICSI are still a matter of concern. The purpose of the present study was to investigate psychological outcomes for 5-year-old children born after ICSI and compare these with outcomes for children born after spontaneous conception (SC). METHODS: Three hundred singleton children born after ICSI in Belgium, Sweden and the USA were matched by maternal age, child age and gender. Outcome measures included the Wechsler Preschool and Primary scales of intelligence (WPPSI-R), Peabody Developmental Motor Scales, Parenting Stress Index and Child Behaviour Checklist. RESULTS: Regarding cognitive development, no significant differences were found on WPPSI-R verbal and performance scales between ICSI and SC children. However, some differences were noted on subtests of the Performance Scale. ICSI children more often obtained a score below 1 SD of the mean on the subtests: Object Assembly, Block Design and Mazes (all P<0.05). Significant differences by site (i.e. Belgium, Sweden and New York) were found on subtests related to parenting stress, child behaviour problems and motor development (all P<0.05). These findings can probably be explained by variables other than conception mode, such as cultural differences and selection bias. CONCLUSIONS: Although the finding that a higher proportion of ICSI children obtained scores below the cut-off on some of the visual-spatial subscales of the WPPSI-R warrants further investigation, ICSI does not appear to affect the psychological well-being or cognitive development at age 5. SN - 0268-1161 UR - https://www.unboundmedicine.com/medline/citation/15358721/Psychological_follow_up_study_of_5_year_old_ICSI_children_ DB - PRIME DP - Unbound Medicine ER -