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Role of noninvasive tests (C-urea breath test and stool antigen test) as additional tools in diagnosis of Helicobacter pylori infection in patients with atrophic body gastritis.
Helicobacter. 2004 Oct; 9(5):436-42.H

Abstract

BACKGROUND

Detection of Helicobacter pylori infection in atrophic body gastritis (ABG) is difficult, as during progression of body atrophy, H. pylori disappears.

AIM

To increase the diagnostic yield of detection of active H. pylori infection in atrophic body gastritis patients by using noninvasive tests such as (13)C-Urea Breath Test ((13)C-UBT) and H. pylori stool antigen test (HpSA) would be useful.

PATIENTS

27 consecutive patients with newly-diagnosed atrophic body gastritis (19F/7M, age 27-73 years).

METHODS

Gastroscopy with biopsies (antrum n = 3, body n = 3) and histology according to updated Sydney system, H. pylori IgG serology, (13)C-UBT, and HpSA.

RESULTS

All tests used in the diagnosis of H. pylori infection were in agreement in 9/27 atrophic body gastritis patients (33.3%), being all positive in four (14.8%) and all negative in five patients (18.5%). Ten of the 27 (37%) patients were Giemsa stain-positive and serology-positive (group I). Seventeen of the 27 (63%) patients were Giemsa stain-negative: 5/17 with positive serology (group II) and 12/17 with negative serology (group III). In group I, 5/10 (50%) were (13)C-UBT positive and 4/10 (40%) HpSA positive. In group II, two patients were (13)C-UBT positive, but all were HpSA negative. Also in group III, all patients were HpSA negative, but one had a positive (13)C-UBT.

CONCLUSIONS

In atrophic body gastritis patients, neither (13)C-UBT nor HpSA per se add useful information regarding active H. pylori infection, but these noninvasive tests may be important in combination with histology and serology to define the H. pylori status in some atrophic body gastritis patients.

Authors+Show Affiliations

Digestive and Liver Disease Unit, II Medical School, University La Sapienza, Rome, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15361083

Citation

Lahner, Edith, et al. "Role of Noninvasive Tests (C-urea Breath Test and Stool Antigen Test) as Additional Tools in Diagnosis of Helicobacter Pylori Infection in Patients With Atrophic Body Gastritis." Helicobacter, vol. 9, no. 5, 2004, pp. 436-42.
Lahner E, Vaira D, Figura N, et al. Role of noninvasive tests (C-urea breath test and stool antigen test) as additional tools in diagnosis of Helicobacter pylori infection in patients with atrophic body gastritis. Helicobacter. 2004;9(5):436-42.
Lahner, E., Vaira, D., Figura, N., Pilozzi, E., Pasquali, A., Severi, C., Perna, F., Delle Fave, G., & Annibale, B. (2004). Role of noninvasive tests (C-urea breath test and stool antigen test) as additional tools in diagnosis of Helicobacter pylori infection in patients with atrophic body gastritis. Helicobacter, 9(5), 436-42.
Lahner E, et al. Role of Noninvasive Tests (C-urea Breath Test and Stool Antigen Test) as Additional Tools in Diagnosis of Helicobacter Pylori Infection in Patients With Atrophic Body Gastritis. Helicobacter. 2004;9(5):436-42. PubMed PMID: 15361083.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of noninvasive tests (C-urea breath test and stool antigen test) as additional tools in diagnosis of Helicobacter pylori infection in patients with atrophic body gastritis. AU - Lahner,Edith, AU - Vaira,Dino, AU - Figura,Natale, AU - Pilozzi,Emanuela, AU - Pasquali,Amelia, AU - Severi,Carola, AU - Perna,Federico, AU - Delle Fave,Gianfranco, AU - Annibale,Bruno, PY - 2004/9/14/pubmed PY - 2005/5/17/medline PY - 2004/9/14/entrez SP - 436 EP - 42 JF - Helicobacter JO - Helicobacter VL - 9 IS - 5 N2 - BACKGROUND: Detection of Helicobacter pylori infection in atrophic body gastritis (ABG) is difficult, as during progression of body atrophy, H. pylori disappears. AIM: To increase the diagnostic yield of detection of active H. pylori infection in atrophic body gastritis patients by using noninvasive tests such as (13)C-Urea Breath Test ((13)C-UBT) and H. pylori stool antigen test (HpSA) would be useful. PATIENTS: 27 consecutive patients with newly-diagnosed atrophic body gastritis (19F/7M, age 27-73 years). METHODS: Gastroscopy with biopsies (antrum n = 3, body n = 3) and histology according to updated Sydney system, H. pylori IgG serology, (13)C-UBT, and HpSA. RESULTS: All tests used in the diagnosis of H. pylori infection were in agreement in 9/27 atrophic body gastritis patients (33.3%), being all positive in four (14.8%) and all negative in five patients (18.5%). Ten of the 27 (37%) patients were Giemsa stain-positive and serology-positive (group I). Seventeen of the 27 (63%) patients were Giemsa stain-negative: 5/17 with positive serology (group II) and 12/17 with negative serology (group III). In group I, 5/10 (50%) were (13)C-UBT positive and 4/10 (40%) HpSA positive. In group II, two patients were (13)C-UBT positive, but all were HpSA negative. Also in group III, all patients were HpSA negative, but one had a positive (13)C-UBT. CONCLUSIONS: In atrophic body gastritis patients, neither (13)C-UBT nor HpSA per se add useful information regarding active H. pylori infection, but these noninvasive tests may be important in combination with histology and serology to define the H. pylori status in some atrophic body gastritis patients. SN - 1083-4389 UR - https://www.unboundmedicine.com/medline/citation/15361083/Role_of_noninvasive_tests__C_urea_breath_test_and_stool_antigen_test__as_additional_tools_in_diagnosis_of_Helicobacter_pylori_infection_in_patients_with_atrophic_body_gastritis_ DB - PRIME DP - Unbound Medicine ER -