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Endocrine tumors of the duodenum. A study of 55 cases relative to clinicopathological features and hormone content.
Hepatogastroenterology. 2004 Sep-Oct; 51(59):1367-71.H

Abstract

BACKGROUND/AIMS

Study of prognosis of duodenal endocrine tumors.

METHODOLOGY

Retrospective study concerned 55 duodenal endocrine tumors discovered in biopsy or surgical specimens. Follow-up records available for 49 patients indicated that inconspicuous associated clinical manifestations were often found subsequently. Seven patients were classified as Zollinger-Ellison syndrome and seven as multiple endocrine neoplasia (6 MEN I and 1 MEN II).

RESULTS

Tumors were small (mean 1.28cm) and located preferentially in the first and second part of the duodenum. Fifty-four were well-differentiated and one poorly differentiated. Immunochemistry revealed 30 G-cell tumors (54.6%), 15 D-cell (27.3%), two plurihormonal (EC cell and G cell), and one GRH-cell, whereas seven could not be classified. Fifteen patients died (five in relation to their disease). Twenty-one had metastases (liver, nodes, lung), eight of whom are still alive.

CONCLUSIONS

Eighty-eight percent of duodenal endocrine tumors were gastrinomas, small plurifocal tumors and somatostatinomas preferentially located in the ampullar region and diagnosed because of hematemesis or icterus. Size is an important prognostic factor in determining whether surgery is required. The prognosis is better for D- and G-cell tumors than pancreatic endocrine tumors. Duodenal endocrine tumors in multiple endocrine neoplasia have a good prognosis, but can be associated with pancreatic plurihormonal tumors and metastases.

Authors+Show Affiliations

Department of Pathology, University Hospital, Nantes, France. mfheymann@chu-nantes.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15362754

Citation

Heymann, M F., et al. "Endocrine Tumors of the Duodenum. a Study of 55 Cases Relative to Clinicopathological Features and Hormone Content." Hepato-gastroenterology, vol. 51, no. 59, 2004, pp. 1367-71.
Heymann MF, Hamy A, Triau S, et al. Endocrine tumors of the duodenum. A study of 55 cases relative to clinicopathological features and hormone content. Hepatogastroenterology. 2004;51(59):1367-71.
Heymann, M. F., Hamy, A., Triau, S., Miraillé, E., Toquet, C., Chomarat, H., Cohen, C., Maitre, F., & Le Bodie, M. F. (2004). Endocrine tumors of the duodenum. A study of 55 cases relative to clinicopathological features and hormone content. Hepato-gastroenterology, 51(59), 1367-71.
Heymann MF, et al. Endocrine Tumors of the Duodenum. a Study of 55 Cases Relative to Clinicopathological Features and Hormone Content. Hepatogastroenterology. 2004 Sep-Oct;51(59):1367-71. PubMed PMID: 15362754.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endocrine tumors of the duodenum. A study of 55 cases relative to clinicopathological features and hormone content. AU - Heymann,M F, AU - Hamy,A, AU - Triau,S, AU - Miraillé,E, AU - Toquet,C, AU - Chomarat,H, AU - Cohen,C, AU - Maitre,F, AU - Le Bodie,M F, PY - 2004/9/15/pubmed PY - 2004/10/13/medline PY - 2004/9/15/entrez SP - 1367 EP - 71 JF - Hepato-gastroenterology JO - Hepatogastroenterology VL - 51 IS - 59 N2 - BACKGROUND/AIMS: Study of prognosis of duodenal endocrine tumors. METHODOLOGY: Retrospective study concerned 55 duodenal endocrine tumors discovered in biopsy or surgical specimens. Follow-up records available for 49 patients indicated that inconspicuous associated clinical manifestations were often found subsequently. Seven patients were classified as Zollinger-Ellison syndrome and seven as multiple endocrine neoplasia (6 MEN I and 1 MEN II). RESULTS: Tumors were small (mean 1.28cm) and located preferentially in the first and second part of the duodenum. Fifty-four were well-differentiated and one poorly differentiated. Immunochemistry revealed 30 G-cell tumors (54.6%), 15 D-cell (27.3%), two plurihormonal (EC cell and G cell), and one GRH-cell, whereas seven could not be classified. Fifteen patients died (five in relation to their disease). Twenty-one had metastases (liver, nodes, lung), eight of whom are still alive. CONCLUSIONS: Eighty-eight percent of duodenal endocrine tumors were gastrinomas, small plurifocal tumors and somatostatinomas preferentially located in the ampullar region and diagnosed because of hematemesis or icterus. Size is an important prognostic factor in determining whether surgery is required. The prognosis is better for D- and G-cell tumors than pancreatic endocrine tumors. Duodenal endocrine tumors in multiple endocrine neoplasia have a good prognosis, but can be associated with pancreatic plurihormonal tumors and metastases. SN - 0172-6390 UR - https://www.unboundmedicine.com/medline/citation/15362754/Endocrine_tumors_of_the_duodenum__A_study_of_55_cases_relative_to_clinicopathological_features_and_hormone_content_ L2 - https://medlineplus.gov/intestinalcancer.html DB - PRIME DP - Unbound Medicine ER -