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The effect of H2-receptor antagonist and proton pump inhibitor on microbial proliferation in the stomach.
Hepatogastroenterology. 2004 Sep-Oct; 51(59):1540-3.H

Abstract

BACKGROUND/AIMS

Intra-gastric bacterial proliferation is frequent in patients with hypochlohydria. However, status of gastric bacterial infection in patients receiving proton pump inhibitor or H2-receptor antagonist remains controversial. The purpose of this study was to investigate the microbial condition of the stomach in patients who received H2-receptor antagonist or proton pump inhibitor.

METHODOLOGY

Between November 2000 and January 2002, 102 patients were enrolled in this study. Of these, 52 did not receive any treatment (group I), 26 received H2-receptor antagonist (group II), and 24 received proton pump inhibitor (group III). Ten mL of gastric juice were aspirated for culture during endoscopic examination. The aerobic and anaerobic bacterial and fungal cultures were performed immediately. A glass pH meter measured the pH of the gastric juice.

RESULTS

The intra-gastric pH was 2.91+/-2.06 (mean +/- SD), 4.12+/-2.83, and 5.11+/-2.47 for groups I, II, and III, respectively (p=0.001 between groups I and III, p>0.05 between groups I and II, and groups II and III). The positive bacterial culture rates were 66.7% (16/24) in group III, 46.2% (12/26) in group II, and 28.8% (15/52) in group I (p=0.007 between groups III and I,p>0.05 between groups I and II, and groups II and III). The positive candidal culture rates were 12.5% (3/24) in group III, 11.5% (3/26) in group II, and 17.3% (9/52) in group I (p>0.05).

CONCLUSIONS

Patients who received proton pump inhibitor had more acid suppression and intra-gastric bacterial infection than those of the control group. The intra-gastric candidal infection was not related to intra-gastric pH or anti-secretory medication in this study.

Authors+Show Affiliations

Division of Gastroenterology, Department of Medicine, Cardinal Tien Hospital and School of Medicine Fu-Jen Catholic University, Taipei, Taiwan, ROC.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

15362796

Citation

Wang, Kun, et al. "The Effect of H2-receptor Antagonist and Proton Pump Inhibitor On Microbial Proliferation in the Stomach." Hepato-gastroenterology, vol. 51, no. 59, 2004, pp. 1540-3.
Wang K, Lin HJ, Perng CL, et al. The effect of H2-receptor antagonist and proton pump inhibitor on microbial proliferation in the stomach. Hepatogastroenterology. 2004;51(59):1540-3.
Wang, K., Lin, H. J., Perng, C. L., Tseng, G. Y., Yu, K. W., Chang, F. Y., & Lee, S. D. (2004). The effect of H2-receptor antagonist and proton pump inhibitor on microbial proliferation in the stomach. Hepato-gastroenterology, 51(59), 1540-3.
Wang K, et al. The Effect of H2-receptor Antagonist and Proton Pump Inhibitor On Microbial Proliferation in the Stomach. Hepatogastroenterology. 2004 Sep-Oct;51(59):1540-3. PubMed PMID: 15362796.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of H2-receptor antagonist and proton pump inhibitor on microbial proliferation in the stomach. AU - Wang,Kun, AU - Lin,Hwai-Jeng, AU - Perng,Chin-Lin, AU - Tseng,Guan-Ying, AU - Yu,Kwok-Woon, AU - Chang,Full-Young, AU - Lee,Shou-Dong, PY - 2004/9/15/pubmed PY - 2004/10/13/medline PY - 2004/9/15/entrez SP - 1540 EP - 3 JF - Hepato-gastroenterology JO - Hepatogastroenterology VL - 51 IS - 59 N2 - BACKGROUND/AIMS: Intra-gastric bacterial proliferation is frequent in patients with hypochlohydria. However, status of gastric bacterial infection in patients receiving proton pump inhibitor or H2-receptor antagonist remains controversial. The purpose of this study was to investigate the microbial condition of the stomach in patients who received H2-receptor antagonist or proton pump inhibitor. METHODOLOGY: Between November 2000 and January 2002, 102 patients were enrolled in this study. Of these, 52 did not receive any treatment (group I), 26 received H2-receptor antagonist (group II), and 24 received proton pump inhibitor (group III). Ten mL of gastric juice were aspirated for culture during endoscopic examination. The aerobic and anaerobic bacterial and fungal cultures were performed immediately. A glass pH meter measured the pH of the gastric juice. RESULTS: The intra-gastric pH was 2.91+/-2.06 (mean +/- SD), 4.12+/-2.83, and 5.11+/-2.47 for groups I, II, and III, respectively (p=0.001 between groups I and III, p>0.05 between groups I and II, and groups II and III). The positive bacterial culture rates were 66.7% (16/24) in group III, 46.2% (12/26) in group II, and 28.8% (15/52) in group I (p=0.007 between groups III and I,p>0.05 between groups I and II, and groups II and III). The positive candidal culture rates were 12.5% (3/24) in group III, 11.5% (3/26) in group II, and 17.3% (9/52) in group I (p>0.05). CONCLUSIONS: Patients who received proton pump inhibitor had more acid suppression and intra-gastric bacterial infection than those of the control group. The intra-gastric candidal infection was not related to intra-gastric pH or anti-secretory medication in this study. SN - 0172-6390 UR - https://www.unboundmedicine.com/medline/citation/15362796/The_effect_of_H2_receptor_antagonist_and_proton_pump_inhibitor_on_microbial_proliferation_in_the_stomach_ DB - PRIME DP - Unbound Medicine ER -