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The use of tumor markers as predictors of prognosis in gastric cancer.
Hepatogastroenterology. 2004 Sep-Oct; 51(59):1544-7.H

Abstract

BACKGROUND/AIMS

The aim of this study was to evaluate the prognostic significance of serum carcinoembryonic antigen (CEA) and carbohydrate antigen (CA19-9) levels in patients with gastric cancer.

METHODOLOGY

During the period January 2000 and January 2003, 36 patients operated for primary gastric cancer, at Sisli Etfal Training and Research Hospital, Department of General Surgery, were analyzed. Serum CEA and CA19-9 levels were determined preoperatively and the correlation between the elevated levels of tumor markers and several clinicopathological features, and survival were evaluated.

RESULTS

Elevated serum CEA and CA19-9 levels were determined in 10 of 35 patients (28.6%), and 9 of 31 patients (29%), respectively, and both markers were elevated in 3 of 31 patients (9.6%). Elevated levels of CEA correlated with depth of invasion (p=0.018) and pathological stage (p=0.029); elevated levels of CA19-9 correlated with lymph node metastasis (p=0.026); and elevated levels of both markers correlated well with lymph node metastasis (p=0.031). The survival of patients with normal CEA levels was significantly better than those with elevated levels (p=0.0072).

CONCLUSIONS

Preoperative serum CEA and CA19-9 levels may add useful information in patients with gastric carcinoma, and CEA level is a predictor of prognosis.

Authors+Show Affiliations

Department of General Surgery, Sisli Etfal Training and Research Hospital, Istanbul, Turkey. mmihmanli@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15362797

Citation

Mihmanli, Mehmet, et al. "The Use of Tumor Markers as Predictors of Prognosis in Gastric Cancer." Hepato-gastroenterology, vol. 51, no. 59, 2004, pp. 1544-7.
Mihmanli M, Dilege E, Demir U, et al. The use of tumor markers as predictors of prognosis in gastric cancer. Hepatogastroenterology. 2004;51(59):1544-7.
Mihmanli, M., Dilege, E., Demir, U., Coskun, H., Eroglu, T., & Uysalol, M. D. (2004). The use of tumor markers as predictors of prognosis in gastric cancer. Hepato-gastroenterology, 51(59), 1544-7.
Mihmanli M, et al. The Use of Tumor Markers as Predictors of Prognosis in Gastric Cancer. Hepatogastroenterology. 2004 Sep-Oct;51(59):1544-7. PubMed PMID: 15362797.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The use of tumor markers as predictors of prognosis in gastric cancer. AU - Mihmanli,Mehmet, AU - Dilege,Ece, AU - Demir,Uygar, AU - Coskun,Halil, AU - Eroglu,Tulay, AU - Uysalol,Mehtap D, PY - 2004/9/15/pubmed PY - 2004/10/13/medline PY - 2004/9/15/entrez SP - 1544 EP - 7 JF - Hepato-gastroenterology JO - Hepatogastroenterology VL - 51 IS - 59 N2 - BACKGROUND/AIMS: The aim of this study was to evaluate the prognostic significance of serum carcinoembryonic antigen (CEA) and carbohydrate antigen (CA19-9) levels in patients with gastric cancer. METHODOLOGY: During the period January 2000 and January 2003, 36 patients operated for primary gastric cancer, at Sisli Etfal Training and Research Hospital, Department of General Surgery, were analyzed. Serum CEA and CA19-9 levels were determined preoperatively and the correlation between the elevated levels of tumor markers and several clinicopathological features, and survival were evaluated. RESULTS: Elevated serum CEA and CA19-9 levels were determined in 10 of 35 patients (28.6%), and 9 of 31 patients (29%), respectively, and both markers were elevated in 3 of 31 patients (9.6%). Elevated levels of CEA correlated with depth of invasion (p=0.018) and pathological stage (p=0.029); elevated levels of CA19-9 correlated with lymph node metastasis (p=0.026); and elevated levels of both markers correlated well with lymph node metastasis (p=0.031). The survival of patients with normal CEA levels was significantly better than those with elevated levels (p=0.0072). CONCLUSIONS: Preoperative serum CEA and CA19-9 levels may add useful information in patients with gastric carcinoma, and CEA level is a predictor of prognosis. SN - 0172-6390 UR - https://www.unboundmedicine.com/medline/citation/15362797/The_use_of_tumor_markers_as_predictors_of_prognosis_in_gastric_cancer_ L2 - https://medlineplus.gov/stomachcancer.html DB - PRIME DP - Unbound Medicine ER -