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Japanese encephalitis virus (JEV) is an important cause of encephalitis among children in Cuddalore district, Tamil Nadu, India.
J Clin Virol. 2004 Oct; 31(2):153-9.JC

Abstract

BACKGROUND

Japanese encephalitis (JE) is endemic in Cuddalore district, Tamil Nadu (TN), Southern India. The reports of JE cases from the local hospitals did not reflect the actual disease burden. It is likely that these cases were attending the nearby referral hospitals, for want of better treatment facilities.

OBJECTIVES

Between July 2002 and February 2003, a pilot study was undertaken to examine whether JE was a component of paediatric acute encephalitis syndrome (AES) reported to two major referral hospitals adjacent to Cuddalore, and to map the distribution of the JE cases.

STUDY DESIGN

A total of 58 hospitalized children [0-15 years] with AES were investigated. Other than the routine laboratory investigations, either CSF or sera or both [depending on the availability] collected from these children were analyzed at Center for Research in Medical Entomology, Madurai (TN) for JEV-antigen, antibody detection, virus isolation and virus genome detection by indirect immunofluorescence, MAC enzyme linked immunosorbent assay (ELISA), insect bioassay and by reverse transcriptase polymerase chain reaction (RT-PCR), respectively.

RESULTS

JE was established in 17 (29%) of 58 AES cases; half of the AES cases [31/58, 53%] and 59% [10/17] of JE cases were confined to JE-endemic areas in Cuddalore district. The JE confirmation scored by different assays varied according to the clinical phase of the illness. The attack rate was high among the children aged 3-8 years. The monthly distribution of acute encephalitic syndrome cases followed the distribution of JE cases [coinciding with the rainy season in this region] suggesting encephalitis of JE origin.

CONCLUSION

In JE-endemic areas, the actual JE burden can be estimated by the collection of JE case reports from the local hospitals and from the referral hospitals. Building of diagnostic facilities in hospitals for JE is necessary to achieve this goal.

Authors+Show Affiliations

Centre for Research in Medical Entomology (Indian Council of Medical Research), 4 Sarojini Street, Chinna Chokkikulam, Madurai-625002, India. lalithakabilan@sify.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15364273

Citation

Kabilan, Lalitha, et al. "Japanese Encephalitis Virus (JEV) Is an Important Cause of Encephalitis Among Children in Cuddalore District, Tamil Nadu, India." Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, vol. 31, no. 2, 2004, pp. 153-9.
Kabilan L, Vrati S, Vrati S, et al. Japanese encephalitis virus (JEV) is an important cause of encephalitis among children in Cuddalore district, Tamil Nadu, India. J Clin Virol. 2004;31(2):153-9.
Kabilan, L., Vrati, S., Vrati, S., Ramesh, S., Srinivasan, S., Appaiahgari, M. B., Arunachalam, N., Thenmozhi, V., Kumaravel, S. M., Samuel, P. P., & Rajendran, R. (2004). Japanese encephalitis virus (JEV) is an important cause of encephalitis among children in Cuddalore district, Tamil Nadu, India. Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 31(2), 153-9.
Kabilan L, et al. Japanese Encephalitis Virus (JEV) Is an Important Cause of Encephalitis Among Children in Cuddalore District, Tamil Nadu, India. J Clin Virol. 2004;31(2):153-9. PubMed PMID: 15364273.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Japanese encephalitis virus (JEV) is an important cause of encephalitis among children in Cuddalore district, Tamil Nadu, India. AU - Kabilan,Lalitha, AU - Vrati,Sudhanshu, AU - Vrati,Sudhansu, AU - Ramesh,S, AU - Srinivasan,S, AU - Appaiahgari,Mohan Babu, AU - Arunachalam,N, AU - Thenmozhi,V, AU - Kumaravel,S Muthu, AU - Samuel,P Philip, AU - Rajendran,R, PY - 2004/01/17/revised PY - 2004/03/08/accepted PY - 2004/9/15/pubmed PY - 2004/12/16/medline PY - 2004/9/15/entrez SP - 153 EP - 9 JF - Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology JO - J Clin Virol VL - 31 IS - 2 N2 - BACKGROUND: Japanese encephalitis (JE) is endemic in Cuddalore district, Tamil Nadu (TN), Southern India. The reports of JE cases from the local hospitals did not reflect the actual disease burden. It is likely that these cases were attending the nearby referral hospitals, for want of better treatment facilities. OBJECTIVES: Between July 2002 and February 2003, a pilot study was undertaken to examine whether JE was a component of paediatric acute encephalitis syndrome (AES) reported to two major referral hospitals adjacent to Cuddalore, and to map the distribution of the JE cases. STUDY DESIGN: A total of 58 hospitalized children [0-15 years] with AES were investigated. Other than the routine laboratory investigations, either CSF or sera or both [depending on the availability] collected from these children were analyzed at Center for Research in Medical Entomology, Madurai (TN) for JEV-antigen, antibody detection, virus isolation and virus genome detection by indirect immunofluorescence, MAC enzyme linked immunosorbent assay (ELISA), insect bioassay and by reverse transcriptase polymerase chain reaction (RT-PCR), respectively. RESULTS: JE was established in 17 (29%) of 58 AES cases; half of the AES cases [31/58, 53%] and 59% [10/17] of JE cases were confined to JE-endemic areas in Cuddalore district. The JE confirmation scored by different assays varied according to the clinical phase of the illness. The attack rate was high among the children aged 3-8 years. The monthly distribution of acute encephalitic syndrome cases followed the distribution of JE cases [coinciding with the rainy season in this region] suggesting encephalitis of JE origin. CONCLUSION: In JE-endemic areas, the actual JE burden can be estimated by the collection of JE case reports from the local hospitals and from the referral hospitals. Building of diagnostic facilities in hospitals for JE is necessary to achieve this goal. SN - 1386-6532 UR - https://www.unboundmedicine.com/medline/citation/15364273/Japanese_encephalitis_virus__JEV__is_an_important_cause_of_encephalitis_among_children_in_Cuddalore_district_Tamil_Nadu_India_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1386653204000836 DB - PRIME DP - Unbound Medicine ER -