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Increased Alix (apoptosis-linked gene-2 interacting protein X) immunoreactivity in the degenerating striatum of rats chronically treated by 3-nitropropionic acid.
Neurosci Lett. 2004 Sep 30; 368(3):309-13.NL

Abstract

Chronic intoxication by 3-nitropropionic acid in the Lewis rat reproduces many features reminiscent of Huntington's disease including behavioural alterations and cortico-striatal degeneration. In particular, in this model, striatal degeneration is accompanied by calpain activation as found in the human disease. The present study was undertaken to determine whether the expression of Alix (apoptosis linked gene-2 interacting protein), a widespread protein involved in neuronal death, would be modified in the striatum and cortex of 3NP-treated rats. The results clearly show that Alix immunoreactivity is increased in the neuronal cell bodies of the lateral striatum, where degeneration is massive. The medial striatum and the cortex that lack neurodegeneration remain only weakly labelled. This is further evidence suggesting an involvement of Alix in the events driving neuronal death.

Authors+Show Affiliations

Laboratoire de Neurophysiologie, ULB Erasme, 808 route de Lennik, 1070 Brussels, Belgium. dablum@ulb.ac.beNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15364417

Citation

Blum, David, et al. "Increased Alix (apoptosis-linked Gene-2 Interacting Protein X) Immunoreactivity in the Degenerating Striatum of Rats Chronically Treated By 3-nitropropionic Acid." Neuroscience Letters, vol. 368, no. 3, 2004, pp. 309-13.
Blum D, Hemming FJ, Galas MC, et al. Increased Alix (apoptosis-linked gene-2 interacting protein X) immunoreactivity in the degenerating striatum of rats chronically treated by 3-nitropropionic acid. Neurosci Lett. 2004;368(3):309-13.
Blum, D., Hemming, F. J., Galas, M. C., Torch, S., Cuvelier, L., Schiffmann, S. N., & Sadoul, R. (2004). Increased Alix (apoptosis-linked gene-2 interacting protein X) immunoreactivity in the degenerating striatum of rats chronically treated by 3-nitropropionic acid. Neuroscience Letters, 368(3), 309-13.
Blum D, et al. Increased Alix (apoptosis-linked Gene-2 Interacting Protein X) Immunoreactivity in the Degenerating Striatum of Rats Chronically Treated By 3-nitropropionic Acid. Neurosci Lett. 2004 Sep 30;368(3):309-13. PubMed PMID: 15364417.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased Alix (apoptosis-linked gene-2 interacting protein X) immunoreactivity in the degenerating striatum of rats chronically treated by 3-nitropropionic acid. AU - Blum,David, AU - Hemming,Fiona J, AU - Galas,Marie-Christine, AU - Torch,Sakina, AU - Cuvelier,Laetitia, AU - Schiffmann,Serge N, AU - Sadoul,Remy, PY - 2004/06/05/received PY - 2004/07/15/revised PY - 2004/07/15/accepted PY - 2004/9/15/pubmed PY - 2005/2/3/medline PY - 2004/9/15/entrez SP - 309 EP - 13 JF - Neuroscience letters JO - Neurosci Lett VL - 368 IS - 3 N2 - Chronic intoxication by 3-nitropropionic acid in the Lewis rat reproduces many features reminiscent of Huntington's disease including behavioural alterations and cortico-striatal degeneration. In particular, in this model, striatal degeneration is accompanied by calpain activation as found in the human disease. The present study was undertaken to determine whether the expression of Alix (apoptosis linked gene-2 interacting protein), a widespread protein involved in neuronal death, would be modified in the striatum and cortex of 3NP-treated rats. The results clearly show that Alix immunoreactivity is increased in the neuronal cell bodies of the lateral striatum, where degeneration is massive. The medial striatum and the cortex that lack neurodegeneration remain only weakly labelled. This is further evidence suggesting an involvement of Alix in the events driving neuronal death. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/15364417/Increased_Alix__apoptosis_linked_gene_2_interacting_protein_X__immunoreactivity_in_the_degenerating_striatum_of_rats_chronically_treated_by_3_nitropropionic_acid_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(04)00908-5 DB - PRIME DP - Unbound Medicine ER -