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Repeated dose toxicity of alfa-cypermethrin in rats.
J Vet Sci. 2004 Sep; 5(3):241-5.JV

Abstract

The present study was performed to investigate the subacute effect of alpha-cypermethrin (alpha-CP) in rats. Alfacypermethrin a synthetic pyrethroid insecticide, dissolved in dimethyl sulfoxide (DMSO) and oral LD50 was investigated after administering orally different doses in rats and was determined as 145 mg/kg. Other groups of rats were given repeated daily oral dose (1/10 LD50) of alpha-CP for 30 days. The animals were sacrificed on 31st day. Activities of various enzymes, cytochrome P450 and b5 contents in liver, hepatic antioxidant status, tissue residue concentration, haemogram and pathological changes were studied. It increased the serum aminotransaminases (AST, ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) activities and blood glucose level significantly. alpha-CP decreased RBC count, PCV and Hb level significantly. It significantly decreased cytochrome P450 in liver. Residues were present in different tissues. It increased malondialdehyde (MDA) level, while decreased the activities of catalase (CAT), superoxide dismutase (SOD) and glycogen level in liver significantly. Mild to moderate histological alterations were observed in lungs, liver, stomach, kidneys, testes and cerebellum. So repeated daily oral doses of alpha-CP at 1/10LD50 altered the biochemical parameters, decreased cytochrome P450 content, antioxidant status, which correlated with histopathological changes of tissues.

Authors+Show Affiliations

I A H & V B (R&T), Room No. 122, 68-K. B. Sarani, Kolkata 700037, India. skmv2@rediffmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15365239

Citation

Manna, S, et al. "Repeated Dose Toxicity of Alfa-cypermethrin in Rats." Journal of Veterinary Science, vol. 5, no. 3, 2004, pp. 241-5.
Manna S, Bhattacharyya D, Mandal TK, et al. Repeated dose toxicity of alfa-cypermethrin in rats. J Vet Sci. 2004;5(3):241-5.
Manna, S., Bhattacharyya, D., Mandal, T. K., & Das, S. (2004). Repeated dose toxicity of alfa-cypermethrin in rats. Journal of Veterinary Science, 5(3), 241-5.
Manna S, et al. Repeated Dose Toxicity of Alfa-cypermethrin in Rats. J Vet Sci. 2004;5(3):241-5. PubMed PMID: 15365239.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Repeated dose toxicity of alfa-cypermethrin in rats. AU - Manna,S, AU - Bhattacharyya,D, AU - Mandal,T K, AU - Das,S, PY - 2004/9/15/pubmed PY - 2004/12/16/medline PY - 2004/9/15/entrez SP - 241 EP - 5 JF - Journal of veterinary science JO - J. Vet. Sci. VL - 5 IS - 3 N2 - The present study was performed to investigate the subacute effect of alpha-cypermethrin (alpha-CP) in rats. Alfacypermethrin a synthetic pyrethroid insecticide, dissolved in dimethyl sulfoxide (DMSO) and oral LD50 was investigated after administering orally different doses in rats and was determined as 145 mg/kg. Other groups of rats were given repeated daily oral dose (1/10 LD50) of alpha-CP for 30 days. The animals were sacrificed on 31st day. Activities of various enzymes, cytochrome P450 and b5 contents in liver, hepatic antioxidant status, tissue residue concentration, haemogram and pathological changes were studied. It increased the serum aminotransaminases (AST, ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) activities and blood glucose level significantly. alpha-CP decreased RBC count, PCV and Hb level significantly. It significantly decreased cytochrome P450 in liver. Residues were present in different tissues. It increased malondialdehyde (MDA) level, while decreased the activities of catalase (CAT), superoxide dismutase (SOD) and glycogen level in liver significantly. Mild to moderate histological alterations were observed in lungs, liver, stomach, kidneys, testes and cerebellum. So repeated daily oral doses of alpha-CP at 1/10LD50 altered the biochemical parameters, decreased cytochrome P450 content, antioxidant status, which correlated with histopathological changes of tissues. SN - 1229-845X UR - https://www.unboundmedicine.com/medline/citation/15365239/Repeated_dose_toxicity_of_alfa_cypermethrin_in_rats_ DB - PRIME DP - Unbound Medicine ER -