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In vitro activity of commercial valerian root extracts against human cytochrome P450 3A4.
J Pharm Pharm Sci. 2004 Aug 12; 7(2):265-73.JP

Abstract

PURPOSE

Valerian root (Valeriana officinalis L.) has been used since antiquity as a medicinal herb. Recent studies have found that certain herbal products used concomitantly with conventional therapeutic products can markedly affect drug disposition.

METHODS

The in vitro effect of aliquots from 14 commercially available single-entity and blended products containing valerian root on cytochrome P450 CYP3A4-mediated metabolism and P-glycoprotein transport has been determined with aqueous, ethanol and acetonitrile extracts.

RESULTS

Hydroxyvalerenic acid, acetoxyvalerenic acid and valerenic acid content was analyzed and wide variation was found between samples and compared to the concentrations noted on the product labels. Valerian extracts from the products tested also exhibited a marked capacity to inhibit cytochrome P450 3A4-mediated metabolism and P-glycoprotein transport based upon the ATPase assay.

CONCLUSIONS

There is wide variation between commercially available samples of valerian root. The findings from this study suggest that valerian root may have an initial inhibitory effect when taken with therapeutic products. Further work is warranted to determine whether valerian root can affect other CYP450 isozymes and how the results of this in vitro investigation can be extrapolated to in vivo situations.

Authors+Show Affiliations

Office of Science, Therapeutic Products Directorate, Health Canada, Ottawa, Ontario, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15367385

Citation

Lefebvre, Tania, et al. "In Vitro Activity of Commercial Valerian Root Extracts Against Human Cytochrome P450 3A4." Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Societe Canadienne Des Sciences Pharmaceutiques, vol. 7, no. 2, 2004, pp. 265-73.
Lefebvre T, Foster BC, Drouin CE, et al. In vitro activity of commercial valerian root extracts against human cytochrome P450 3A4. J Pharm Pharm Sci. 2004;7(2):265-73.
Lefebvre, T., Foster, B. C., Drouin, C. E., Krantis, A., Livesey, J. F., & Jordan, S. A. (2004). In vitro activity of commercial valerian root extracts against human cytochrome P450 3A4. Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Societe Canadienne Des Sciences Pharmaceutiques, 7(2), 265-73.
Lefebvre T, et al. In Vitro Activity of Commercial Valerian Root Extracts Against Human Cytochrome P450 3A4. J Pharm Pharm Sci. 2004 Aug 12;7(2):265-73. PubMed PMID: 15367385.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro activity of commercial valerian root extracts against human cytochrome P450 3A4. AU - Lefebvre,Tania, AU - Foster,Brian C, AU - Drouin,Cathy E, AU - Krantis,Anthony, AU - Livesey,John F, AU - Jordan,Scott A, Y1 - 2004/08/12/ PY - 2004/9/16/pubmed PY - 2005/1/4/medline PY - 2004/9/16/entrez SP - 265 EP - 73 JF - Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques JO - J Pharm Pharm Sci VL - 7 IS - 2 N2 - PURPOSE: Valerian root (Valeriana officinalis L.) has been used since antiquity as a medicinal herb. Recent studies have found that certain herbal products used concomitantly with conventional therapeutic products can markedly affect drug disposition. METHODS: The in vitro effect of aliquots from 14 commercially available single-entity and blended products containing valerian root on cytochrome P450 CYP3A4-mediated metabolism and P-glycoprotein transport has been determined with aqueous, ethanol and acetonitrile extracts. RESULTS: Hydroxyvalerenic acid, acetoxyvalerenic acid and valerenic acid content was analyzed and wide variation was found between samples and compared to the concentrations noted on the product labels. Valerian extracts from the products tested also exhibited a marked capacity to inhibit cytochrome P450 3A4-mediated metabolism and P-glycoprotein transport based upon the ATPase assay. CONCLUSIONS: There is wide variation between commercially available samples of valerian root. The findings from this study suggest that valerian root may have an initial inhibitory effect when taken with therapeutic products. Further work is warranted to determine whether valerian root can affect other CYP450 isozymes and how the results of this in vitro investigation can be extrapolated to in vivo situations. SN - 1482-1826 UR - https://www.unboundmedicine.com/medline/citation/15367385/In_vitro_activity_of_commercial_valerian_root_extracts_against_human_cytochrome_P450_3A4_ L2 - http://www.ualberta.ca/~csps/JPPS7(2)/B.Foster/valerian.htm DB - PRIME DP - Unbound Medicine ER -