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Comparative effects of curcumin and an analog of curcumin on alcohol and PUFA induced oxidative stress.
J Pharm Pharm Sci. 2004 Aug 20; 7(2):274-83.JP

Abstract

PURPOSE

Alcoholic liver disease is a major medical complication of alcohol abuse and a common liver disease in western countries. Increasing evidence demonstrates that oxidative stress plays an important etiologic role in the development of alcoholic liver disease. Alcohol alone or in combination with high fat is known to cause oxidative injury. The present study therefore aims at evaluating the protective role of curcumin, an active principle of turmeric and a synthetic analog of curcumin (CA) on alcohol and thermally oxidised sunflower oil (DeltaPUFA) induced oxidative stress.

METHODS

Male albino Wistar rats were used for the experimental study. The liver marker enzymes: gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), the lipid peroxidative indices: thiobarbituric acid reactive substances (TBARS) and hydroperoxides (HP) and antioxidants such as vitamin C, vitamin E, reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) were used as biomarkers for testing the antioxidant potential of the drugs.

RESULTS

The liver marker enzymes and lipid peroxidative indices were increased significantly in alcohol, DeltaPUFA and alcohol + DeltaPUFA groups. Administration of curcumin and CA abrograted this effect. The antioxidant status which was decreased in alcohol, DeltaPUFA and alcohol + DeltaPUFA groups was effectively modulated by both curcumin and CA treatment. However, the reduction in oxidative stress was more pronounced in CA treatment groups compared to curcumin.

CONCLUSION

In conclusion, these observations show that CA exerts its protective effect by decreasing the lipid peroxidation and improving antioxidant status, thus proving itself as an effective antioxidant.

Authors+Show Affiliations

Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15367386

Citation

Rukkumani, Rajagopalan, et al. "Comparative Effects of Curcumin and an Analog of Curcumin On Alcohol and PUFA Induced Oxidative Stress." Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Societe Canadienne Des Sciences Pharmaceutiques, vol. 7, no. 2, 2004, pp. 274-83.
Rukkumani R, Aruna K, Varma PS, et al. Comparative effects of curcumin and an analog of curcumin on alcohol and PUFA induced oxidative stress. J Pharm Pharm Sci. 2004;7(2):274-83.
Rukkumani, R., Aruna, K., Varma, P. S., Rajasekaran, K. N., & Menon, V. P. (2004). Comparative effects of curcumin and an analog of curcumin on alcohol and PUFA induced oxidative stress. Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Societe Canadienne Des Sciences Pharmaceutiques, 7(2), 274-83.
Rukkumani R, et al. Comparative Effects of Curcumin and an Analog of Curcumin On Alcohol and PUFA Induced Oxidative Stress. J Pharm Pharm Sci. 2004 Aug 20;7(2):274-83. PubMed PMID: 15367386.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative effects of curcumin and an analog of curcumin on alcohol and PUFA induced oxidative stress. AU - Rukkumani,Rajagopalan, AU - Aruna,Kode, AU - Varma,Penumathsa Suresh, AU - Rajasekaran,Kallikat Narayanan, AU - Menon,Venugopal Padmanabhan, Y1 - 2004/08/20/ PY - 2004/9/16/pubmed PY - 2004/12/22/medline PY - 2004/9/16/entrez SP - 274 EP - 83 JF - Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques JO - J Pharm Pharm Sci VL - 7 IS - 2 N2 - PURPOSE: Alcoholic liver disease is a major medical complication of alcohol abuse and a common liver disease in western countries. Increasing evidence demonstrates that oxidative stress plays an important etiologic role in the development of alcoholic liver disease. Alcohol alone or in combination with high fat is known to cause oxidative injury. The present study therefore aims at evaluating the protective role of curcumin, an active principle of turmeric and a synthetic analog of curcumin (CA) on alcohol and thermally oxidised sunflower oil (DeltaPUFA) induced oxidative stress. METHODS: Male albino Wistar rats were used for the experimental study. The liver marker enzymes: gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), the lipid peroxidative indices: thiobarbituric acid reactive substances (TBARS) and hydroperoxides (HP) and antioxidants such as vitamin C, vitamin E, reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) were used as biomarkers for testing the antioxidant potential of the drugs. RESULTS: The liver marker enzymes and lipid peroxidative indices were increased significantly in alcohol, DeltaPUFA and alcohol + DeltaPUFA groups. Administration of curcumin and CA abrograted this effect. The antioxidant status which was decreased in alcohol, DeltaPUFA and alcohol + DeltaPUFA groups was effectively modulated by both curcumin and CA treatment. However, the reduction in oxidative stress was more pronounced in CA treatment groups compared to curcumin. CONCLUSION: In conclusion, these observations show that CA exerts its protective effect by decreasing the lipid peroxidation and improving antioxidant status, thus proving itself as an effective antioxidant. SN - 1482-1826 UR - https://www.unboundmedicine.com/medline/citation/15367386/Comparative_effects_of_curcumin_and_an_analog_of_curcumin_on_alcohol_and_PUFA_induced_oxidative_stress_ L2 - http://www.ualberta.ca/~csps/JPPS7(2)/V.Menon/curcumin.htm DB - PRIME DP - Unbound Medicine ER -