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Majewski osteodysplastic primordial dwarfism type II (MOPD II): natural history and clinical findings.
Am J Med Genet A. 2004 Sep 15; 130A(1):55-72.AJ

Abstract

A description of the clinical features of Majewski osteodysplastic primordial dwarfism type II (MOPD II) is presented based on 58 affected individuals (27 from the literature and 31 previously unreported cases). The remarkable features of MOPD II are: severe intrauterine growth retardation (IUGR), severe postnatal growth retardation; relatively proportionate head size at birth which progresses to true and disproportionate microcephaly; progressive disproportion of the short stature secondary to shortening of the distal and middle segments of the limbs; a progressive bony dysplasia with metaphyseal changes in the limbs; epiphyseal delay; progressive loose-jointedness with occasional dislocation or subluxation of the knees, radial heads, and hips; unusual facial features including a prominent nose, eyes which appear prominent in infancy and early childhood, ears which are proportionate, mildly dysplastic and usually missing the lobule; a high squeaky voice; abnormally, small, and often dysplastic or missing dentition; a pleasant, outgoing, sociable personality; and autosomal recessive inheritance. Far-sightedness, scoliosis, unusual pigmentation, and truncal obesity often develop with time. Some individuals seem to have increased susceptibility to infections. A number of affected individuals have developed dilation of the CNS arteries variously described as aneurysms and Moya Moya disease. These vascular changes can be life threatening, even in early years because of rupture, CNS hemorrhage, and strokes. There is variability between affected individuals even within the same family.

Authors+Show Affiliations

Department of Medical Genetics, UBC and Children's and Women's Health Centre of British Columbia Vancouver, British Columbia, Canada. jhall@cw.bc.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

15368497

Citation

Hall, Judith G., et al. "Majewski Osteodysplastic Primordial Dwarfism Type II (MOPD II): Natural History and Clinical Findings." American Journal of Medical Genetics. Part A, vol. 130A, no. 1, 2004, pp. 55-72.
Hall JG, Flora C, Scott CI, et al. Majewski osteodysplastic primordial dwarfism type II (MOPD II): natural history and clinical findings. Am J Med Genet A. 2004;130A(1):55-72.
Hall, J. G., Flora, C., Scott, C. I., Pauli, R. M., & Tanaka, K. I. (2004). Majewski osteodysplastic primordial dwarfism type II (MOPD II): natural history and clinical findings. American Journal of Medical Genetics. Part A, 130A(1), 55-72.
Hall JG, et al. Majewski Osteodysplastic Primordial Dwarfism Type II (MOPD II): Natural History and Clinical Findings. Am J Med Genet A. 2004 Sep 15;130A(1):55-72. PubMed PMID: 15368497.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Majewski osteodysplastic primordial dwarfism type II (MOPD II): natural history and clinical findings. AU - Hall,Judith G, AU - Flora,Christina, AU - Scott,Charles I,Jr AU - Pauli,Richard M, AU - Tanaka,Kimi I, PY - 2004/9/16/pubmed PY - 2004/12/16/medline PY - 2004/9/16/entrez SP - 55 EP - 72 JF - American journal of medical genetics. Part A JO - Am. J. Med. Genet. A VL - 130A IS - 1 N2 - A description of the clinical features of Majewski osteodysplastic primordial dwarfism type II (MOPD II) is presented based on 58 affected individuals (27 from the literature and 31 previously unreported cases). The remarkable features of MOPD II are: severe intrauterine growth retardation (IUGR), severe postnatal growth retardation; relatively proportionate head size at birth which progresses to true and disproportionate microcephaly; progressive disproportion of the short stature secondary to shortening of the distal and middle segments of the limbs; a progressive bony dysplasia with metaphyseal changes in the limbs; epiphyseal delay; progressive loose-jointedness with occasional dislocation or subluxation of the knees, radial heads, and hips; unusual facial features including a prominent nose, eyes which appear prominent in infancy and early childhood, ears which are proportionate, mildly dysplastic and usually missing the lobule; a high squeaky voice; abnormally, small, and often dysplastic or missing dentition; a pleasant, outgoing, sociable personality; and autosomal recessive inheritance. Far-sightedness, scoliosis, unusual pigmentation, and truncal obesity often develop with time. Some individuals seem to have increased susceptibility to infections. A number of affected individuals have developed dilation of the CNS arteries variously described as aneurysms and Moya Moya disease. These vascular changes can be life threatening, even in early years because of rupture, CNS hemorrhage, and strokes. There is variability between affected individuals even within the same family. SN - 1552-4825 UR - https://www.unboundmedicine.com/medline/citation/15368497/Majewski_osteodysplastic_primordial_dwarfism_type_II__MOPD_II_:_natural_history_and_clinical_findings_ L2 - https://doi.org/10.1002/ajmg.a.30203 DB - PRIME DP - Unbound Medicine ER -