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[Study of the strength of compacts of mixed dry binders consisting of powdered cellulose and directly compressible lactose].
Ceska Slov Farm. 2004 Jul; 53(4):183-6.CS

Abstract

The paper studied the strength of compacts of dry binders consisting of powdered cellulose and directly compressible lactose. The powdered cellulose employed was Arbocel A300, the directly compressible lactose, Pharmatosa DCL 21. The first step of the evaluation comprised the tensile strength of compacts and sensitivity of dry binders alone to an addition of magnesium stearate. The same method of evaluation was then used for mixed dry binders from Arbocel A300 and Pharmatosa DCL 21 in ratios of 3:1, 1:1 and 1:3. The tested concentrations of magnesium stearate were 0.4 and 0.8%. Sensitivity of dry binders to an addition of the lubricant was evaluated by means of lubricant sensitivity ratio (LSR) values. The compacts with the highest strength and at the same time the lowest sensitivity to an addition of magnesium stearate were produced using a mixture of Arbocel A300 and Pharmatosa DCL 21 in a ratio of 1:3. The evaluation also included the commercially produced mixed dry binder Cellactosa 80, in which higher sensitivity to an addition of stearate than in a mixture of Arbocel A300 and Pharmatosa DCL 21 in a ratio of 1:3 was found.

Authors+Show Affiliations

Muzíková J
Farmaceutické fakulty Univerzity Karlovy, Hradec Králové. muzikova@faf.cuni.cz
Hájková P
No affiliation info available
Vinklarová S
No affiliation info available

MeSH

CelluloseLactosePharmaceutic AidsPowdersTabletsTechnology, PharmaceuticalTensile Strength

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

cze

PubMed ID

15369229

Citation

Muzíková, J, et al. "[Study of the Strength of Compacts of Mixed Dry Binders Consisting of Powdered Cellulose and Directly Compressible Lactose]." Ceska a Slovenska Farmacie : Casopis Ceske Farmaceuticke Spolecnosti a Slovenske Farmaceuticke Spolecnosti, vol. 53, no. 4, 2004, pp. 183-6.
Muzíková J, Hájková P, Vinklarová S. [Study of the strength of compacts of mixed dry binders consisting of powdered cellulose and directly compressible lactose]. Ceska Slov Farm. 2004;53(4):183-6.
Muzíková, J., Hájková, P., & Vinklarová, S. (2004). [Study of the strength of compacts of mixed dry binders consisting of powdered cellulose and directly compressible lactose]. Ceska a Slovenska Farmacie : Casopis Ceske Farmaceuticke Spolecnosti a Slovenske Farmaceuticke Spolecnosti, 53(4), 183-6.
Muzíková J, Hájková P, Vinklarová S. [Study of the Strength of Compacts of Mixed Dry Binders Consisting of Powdered Cellulose and Directly Compressible Lactose]. Ceska Slov Farm. 2004;53(4):183-6. PubMed PMID: 15369229.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Study of the strength of compacts of mixed dry binders consisting of powdered cellulose and directly compressible lactose]. AU - Muzíková,J, AU - Hájková,P, AU - Vinklarová,S, PY - 2004/9/17/pubmed PY - 2005/10/13/medline PY - 2004/9/17/entrez SP - 183 EP - 6 JF - Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti JO - Ceska Slov Farm VL - 53 IS - 4 N2 - The paper studied the strength of compacts of dry binders consisting of powdered cellulose and directly compressible lactose. The powdered cellulose employed was Arbocel A300, the directly compressible lactose, Pharmatosa DCL 21. The first step of the evaluation comprised the tensile strength of compacts and sensitivity of dry binders alone to an addition of magnesium stearate. The same method of evaluation was then used for mixed dry binders from Arbocel A300 and Pharmatosa DCL 21 in ratios of 3:1, 1:1 and 1:3. The tested concentrations of magnesium stearate were 0.4 and 0.8%. Sensitivity of dry binders to an addition of the lubricant was evaluated by means of lubricant sensitivity ratio (LSR) values. The compacts with the highest strength and at the same time the lowest sensitivity to an addition of magnesium stearate were produced using a mixture of Arbocel A300 and Pharmatosa DCL 21 in a ratio of 1:3. The evaluation also included the commercially produced mixed dry binder Cellactosa 80, in which higher sensitivity to an addition of stearate than in a mixture of Arbocel A300 and Pharmatosa DCL 21 in a ratio of 1:3 was found. SN - 1210-7816 UR - https://www.unboundmedicine.com/medline/citation/15369229/[Study_of_the_strength_of_compacts_of_mixed_dry_binders_consisting_of_powdered_cellulose_and_directly_compressible_lactose]_ DB - PRIME DP - Unbound Medicine ER -