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Folate and cobalamin synergistically decrease the risk of high plasma homocysteine in a nonsupplemented elderly institutionalized population.
Clin Biochem 2004; 37(10):904-10CB

Abstract

OBJECTIVE

Total plasma homocysteine (tHcy) has been associated with an increased risk of cardiovascular disease in the general population and elderly subjects are at high risk of elevated homocysteine because of an impaired vitamin status. The aim of the present study was to determine the independent and interactive association of adequate folate and cobalamin (intake and serum levels) with tHcy in elderly subjects who were not taking vitamin supplementation.

DESIGN AND METHODS

Cross-sectional analysis of a sample of 140 elderly recruited from seven nursing homes in Asturias (Northern Spain). Dietary intake was assessed by a food frequency questionnaire, and serum folate, cobalamin, and tHcy were determined in fasting blood samples.

RESULTS

Mean tHcy concentration was 13.3 micromol/L (upper quartile of tHcy >16.0 micromol/L) and was inversely correlated with serum folate. Subjects with an adequate intake or serum levels of both folate and B12 were at a reduced risk of being in the highest quartile of tHcy. In both cases, the reduction of high tHcy (upper quartile) risk was found to be greater than expected when subjects with high levels of both vitamins were considered together.

CONCLUSIONS

Adequate folate and cobalamin (both intake and serum levels) act synergistically to decrease the risk of high total plasma homocysteine levels in this elderly population.

Authors+Show Affiliations

Departamento de Biología Funcional, Area de Fisiología, Facultad de Medicina, Universidad de Oviedo, 33006, Oviedo, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15369722

Citation

Huerta, José M., et al. "Folate and Cobalamin Synergistically Decrease the Risk of High Plasma Homocysteine in a Nonsupplemented Elderly Institutionalized Population." Clinical Biochemistry, vol. 37, no. 10, 2004, pp. 904-10.
Huerta JM, González S, Vigil E, et al. Folate and cobalamin synergistically decrease the risk of high plasma homocysteine in a nonsupplemented elderly institutionalized population. Clin Biochem. 2004;37(10):904-10.
Huerta, J. M., González, S., Vigil, E., Prada, M., San Martín, J., Fernández, S., ... Lasheras, C. (2004). Folate and cobalamin synergistically decrease the risk of high plasma homocysteine in a nonsupplemented elderly institutionalized population. Clinical Biochemistry, 37(10), pp. 904-10.
Huerta JM, et al. Folate and Cobalamin Synergistically Decrease the Risk of High Plasma Homocysteine in a Nonsupplemented Elderly Institutionalized Population. Clin Biochem. 2004;37(10):904-10. PubMed PMID: 15369722.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Folate and cobalamin synergistically decrease the risk of high plasma homocysteine in a nonsupplemented elderly institutionalized population. AU - Huerta,José M, AU - González,Sonia, AU - Vigil,Elena, AU - Prada,Mercedes, AU - San Martín,Julia, AU - Fernández,Serafina, AU - Patterson,Angeles M, AU - Lasheras,Cristina, PY - 2003/04/04/received PY - 2004/06/28/revised PY - 2004/06/29/accepted PY - 2004/9/17/pubmed PY - 2005/2/23/medline PY - 2004/9/17/entrez SP - 904 EP - 10 JF - Clinical biochemistry JO - Clin. Biochem. VL - 37 IS - 10 N2 - OBJECTIVE: Total plasma homocysteine (tHcy) has been associated with an increased risk of cardiovascular disease in the general population and elderly subjects are at high risk of elevated homocysteine because of an impaired vitamin status. The aim of the present study was to determine the independent and interactive association of adequate folate and cobalamin (intake and serum levels) with tHcy in elderly subjects who were not taking vitamin supplementation. DESIGN AND METHODS: Cross-sectional analysis of a sample of 140 elderly recruited from seven nursing homes in Asturias (Northern Spain). Dietary intake was assessed by a food frequency questionnaire, and serum folate, cobalamin, and tHcy were determined in fasting blood samples. RESULTS: Mean tHcy concentration was 13.3 micromol/L (upper quartile of tHcy >16.0 micromol/L) and was inversely correlated with serum folate. Subjects with an adequate intake or serum levels of both folate and B12 were at a reduced risk of being in the highest quartile of tHcy. In both cases, the reduction of high tHcy (upper quartile) risk was found to be greater than expected when subjects with high levels of both vitamins were considered together. CONCLUSIONS: Adequate folate and cobalamin (both intake and serum levels) act synergistically to decrease the risk of high total plasma homocysteine levels in this elderly population. SN - 0009-9120 UR - https://www.unboundmedicine.com/medline/citation/15369722/Folate_and_cobalamin_synergistically_decrease_the_risk_of_high_plasma_homocysteine_in_a_nonsupplemented_elderly_institutionalized_population_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-9120(04)00177-8 DB - PRIME DP - Unbound Medicine ER -