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Assessment of maternal-fetal status of some essential trace elements in pregnant women in late gestation: relationship with birth weight and placental weight.
J Matern Fetal Neonatal Med. 2004 Jul; 16(1):9-14.JM

Abstract

OBJECTIVE

The status of the essential trace elements copper (Cu), iron (Fe), zinc (Zn), selenium (Se) and molybdenum (Mo) has been investigated in maternal and umbilical cord blood in control, uncomplicated pregnancies at term, and the possibility assessed of a relationship between blood levels of these trace elements and newborn weight and placental weight. Fetal-maternal ratios of the elements were also computed to establish baseline values for the Kuwaiti obstetric population.

METHODS

Blood samples were collected from a maternal vein, the umbilical artery and umbilical vein of normal pregnant women at the time of spontaneous delivery or Cesarean section, and the concentrations of various trace elements determined by atomic absorption spectrophotometry.

RESULTS

The concentration of Cu, Fe, Mo, Se and Zn averaged 2406.1, 3252.1, 11.6, 107.3 and 696.2 microg/l, respectively, in maternal venous blood in the pregnant women (n=39) at term. Umbilical venous/maternal venous ratios of Cu, Fe, Mo, Se and Zn averaged 0.32, 1.96, 1.03, 0.83 and 1.55, respectively. Neonatal birth weight did not correlate with maternal blood levels of the trace elements (p>0.05) in the mother-child pairs studied. However, neonatal weight correlated negatively (p<0.05) with umbilical venous Cu level. Placental weight correlated positively (p<0.05) with Fe and Mo levels and negatively with Zn level in umbilical venous blood.

CONCLUSIONS

Our results indicate an active placental transport for Fe and Zn, while Cu, Mo and Se appear to be exchanged passively between mother and fetus. Evaluation of Fe, Mo, Se and Zn levels in maternal and umbilical cord blood does not appear to be useful in the assessment of fetal growth.

Authors+Show Affiliations

Obstetrics and Gynecology Department, Faculty of Medicine University of Kuwait, Safat, Kuwait.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15370076

Citation

Al-Saleh, E, et al. "Assessment of Maternal-fetal Status of some Essential Trace Elements in Pregnant Women in Late Gestation: Relationship With Birth Weight and Placental Weight." The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, vol. 16, no. 1, 2004, pp. 9-14.
Al-Saleh E, Nandakumaran M, Al-Shammari M, et al. Assessment of maternal-fetal status of some essential trace elements in pregnant women in late gestation: relationship with birth weight and placental weight. J Matern Fetal Neonatal Med. 2004;16(1):9-14.
Al-Saleh, E., Nandakumaran, M., Al-Shammari, M., Al-Falah, F., & Al-Harouny, A. (2004). Assessment of maternal-fetal status of some essential trace elements in pregnant women in late gestation: relationship with birth weight and placental weight. The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 16(1), 9-14.
Al-Saleh E, et al. Assessment of Maternal-fetal Status of some Essential Trace Elements in Pregnant Women in Late Gestation: Relationship With Birth Weight and Placental Weight. J Matern Fetal Neonatal Med. 2004;16(1):9-14. PubMed PMID: 15370076.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of maternal-fetal status of some essential trace elements in pregnant women in late gestation: relationship with birth weight and placental weight. AU - Al-Saleh,E, AU - Nandakumaran,M, AU - Al-Shammari,M, AU - Al-Falah,F, AU - Al-Harouny,A, PY - 2004/9/17/pubmed PY - 2005/3/2/medline PY - 2004/9/17/entrez SP - 9 EP - 14 JF - The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians JO - J Matern Fetal Neonatal Med VL - 16 IS - 1 N2 - OBJECTIVE: The status of the essential trace elements copper (Cu), iron (Fe), zinc (Zn), selenium (Se) and molybdenum (Mo) has been investigated in maternal and umbilical cord blood in control, uncomplicated pregnancies at term, and the possibility assessed of a relationship between blood levels of these trace elements and newborn weight and placental weight. Fetal-maternal ratios of the elements were also computed to establish baseline values for the Kuwaiti obstetric population. METHODS: Blood samples were collected from a maternal vein, the umbilical artery and umbilical vein of normal pregnant women at the time of spontaneous delivery or Cesarean section, and the concentrations of various trace elements determined by atomic absorption spectrophotometry. RESULTS: The concentration of Cu, Fe, Mo, Se and Zn averaged 2406.1, 3252.1, 11.6, 107.3 and 696.2 microg/l, respectively, in maternal venous blood in the pregnant women (n=39) at term. Umbilical venous/maternal venous ratios of Cu, Fe, Mo, Se and Zn averaged 0.32, 1.96, 1.03, 0.83 and 1.55, respectively. Neonatal birth weight did not correlate with maternal blood levels of the trace elements (p>0.05) in the mother-child pairs studied. However, neonatal weight correlated negatively (p<0.05) with umbilical venous Cu level. Placental weight correlated positively (p<0.05) with Fe and Mo levels and negatively with Zn level in umbilical venous blood. CONCLUSIONS: Our results indicate an active placental transport for Fe and Zn, while Cu, Mo and Se appear to be exchanged passively between mother and fetus. Evaluation of Fe, Mo, Se and Zn levels in maternal and umbilical cord blood does not appear to be useful in the assessment of fetal growth. SN - 1476-7058 UR - https://www.unboundmedicine.com/medline/citation/15370076/Assessment_of_maternal_fetal_status_of_some_essential_trace_elements_in_pregnant_women_in_late_gestation:_relationship_with_birth_weight_and_placental_weight_ L2 - https://www.tandfonline.com/doi/full/10.1080/14767050412331283157 DB - PRIME DP - Unbound Medicine ER -