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Effects of a 3-day low-fat diet on metabolic control, insulin sensitivity, lipids and adipocyte hormones in Norwegian subjects with hypertriacylglycerolaemia and type 2 diabetes.
Scand J Clin Lab Invest 2004; 64(6):565-74SJ

Abstract

The metabolic and hormonal impact of rapid dietary changes in type 2 diabetes has not been clarified. The objective of this study was to test whether a short-term, low-fat diet affected metabolic control, insulin sensitivity, lipids and adipocyte hormones in patients with type 2 diabetes with hypertriacylglycerolaemia. Nineteen outpatient subjects (10 M, 9 F) with type 2 diabetes and triacylglycerols >2.2 mmol/L at screening were included in the study. Dietary intake was assessed by weighing during two periods of 3-day baseline diet followed by a 3-day low-fat dietary intervention. The two periods of baseline diet did not differ with respect to relevant variables during intervention. Subjects were advised to increase fibre-rich and low-fat foods and to decrease intake of visible fat in an isoenergetic manner. The percentage of energy from fat was reduced from 39 to 22 (p < 0.0001), median values. Daytime blood glucose did not change and fasting insulin and fasting glucose to insulin ratios were unaffected. Total cholesterol decreased from 6.3 to 6.2 mmol/L (p < 0.005), high-density lipoprotein cholesterol from 1.13 to 1.10 mmol/L (p < 0.048) and the ratio of n-6 to n-3 fatty acids in phospholipids from 2.5 to 1.9 (p < 0.003). Concentrations of leptin decreased from 12.1 to 9.9 ng/mL (p < 0.005) and adiponectin increased from 8.6 to 10.5 microg/mL (p < 0.024). The effect on leptin was confined to women. A low-fat diet intervention for 3 days in insulin-resistant type 2 diabetes affects lipid, adiponectin and leptin levels but fails to improve insulin sensitivity and metabolic control.

Authors+Show Affiliations

Department of Cancer Research and Molecular Medicine, Faculty of Medicine Norwegian University of Science and Technology, Trondheim, Norway. ingrid.l.mostad@medisin.ntnu.noNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15370462

Citation

Mostad, I L., et al. "Effects of a 3-day Low-fat Diet On Metabolic Control, Insulin Sensitivity, Lipids and Adipocyte Hormones in Norwegian Subjects With Hypertriacylglycerolaemia and Type 2 Diabetes." Scandinavian Journal of Clinical and Laboratory Investigation, vol. 64, no. 6, 2004, pp. 565-74.
Mostad IL, Qvigstad E, Bjerve KS, et al. Effects of a 3-day low-fat diet on metabolic control, insulin sensitivity, lipids and adipocyte hormones in Norwegian subjects with hypertriacylglycerolaemia and type 2 diabetes. Scand J Clin Lab Invest. 2004;64(6):565-74.
Mostad, I. L., Qvigstad, E., Bjerve, K. S., & Grill, V. E. (2004). Effects of a 3-day low-fat diet on metabolic control, insulin sensitivity, lipids and adipocyte hormones in Norwegian subjects with hypertriacylglycerolaemia and type 2 diabetes. Scandinavian Journal of Clinical and Laboratory Investigation, 64(6), pp. 565-74.
Mostad IL, et al. Effects of a 3-day Low-fat Diet On Metabolic Control, Insulin Sensitivity, Lipids and Adipocyte Hormones in Norwegian Subjects With Hypertriacylglycerolaemia and Type 2 Diabetes. Scand J Clin Lab Invest. 2004;64(6):565-74. PubMed PMID: 15370462.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of a 3-day low-fat diet on metabolic control, insulin sensitivity, lipids and adipocyte hormones in Norwegian subjects with hypertriacylglycerolaemia and type 2 diabetes. AU - Mostad,I L, AU - Qvigstad,E, AU - Bjerve,K S, AU - Grill,V E, PY - 2004/9/17/pubmed PY - 2005/2/9/medline PY - 2004/9/17/entrez SP - 565 EP - 74 JF - Scandinavian journal of clinical and laboratory investigation JO - Scand. J. Clin. Lab. Invest. VL - 64 IS - 6 N2 - The metabolic and hormonal impact of rapid dietary changes in type 2 diabetes has not been clarified. The objective of this study was to test whether a short-term, low-fat diet affected metabolic control, insulin sensitivity, lipids and adipocyte hormones in patients with type 2 diabetes with hypertriacylglycerolaemia. Nineteen outpatient subjects (10 M, 9 F) with type 2 diabetes and triacylglycerols >2.2 mmol/L at screening were included in the study. Dietary intake was assessed by weighing during two periods of 3-day baseline diet followed by a 3-day low-fat dietary intervention. The two periods of baseline diet did not differ with respect to relevant variables during intervention. Subjects were advised to increase fibre-rich and low-fat foods and to decrease intake of visible fat in an isoenergetic manner. The percentage of energy from fat was reduced from 39 to 22 (p < 0.0001), median values. Daytime blood glucose did not change and fasting insulin and fasting glucose to insulin ratios were unaffected. Total cholesterol decreased from 6.3 to 6.2 mmol/L (p < 0.005), high-density lipoprotein cholesterol from 1.13 to 1.10 mmol/L (p < 0.048) and the ratio of n-6 to n-3 fatty acids in phospholipids from 2.5 to 1.9 (p < 0.003). Concentrations of leptin decreased from 12.1 to 9.9 ng/mL (p < 0.005) and adiponectin increased from 8.6 to 10.5 microg/mL (p < 0.024). The effect on leptin was confined to women. A low-fat diet intervention for 3 days in insulin-resistant type 2 diabetes affects lipid, adiponectin and leptin levels but fails to improve insulin sensitivity and metabolic control. SN - 0036-5513 UR - https://www.unboundmedicine.com/medline/citation/15370462/Effects_of_a_3_day_low_fat_diet_on_metabolic_control_insulin_sensitivity_lipids_and_adipocyte_hormones_in_Norwegian_subjects_with_hypertriacylglycerolaemia_and_type_2_diabetes_ L2 - http://www.tandfonline.com/doi/full/10.1080/00365510410007053 DB - PRIME DP - Unbound Medicine ER -