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Effect of ethanol and some alcoholic beverages on gastric emptying in humans.
Scand J Gastroenterol. 2004 Jul; 39(7):638-44.SJ

Abstract

BACKGROUND

There is a paucity of detailed and controlled studies on the action of ethanol and alcoholic beverages on gastric emptying in humans. This study was designed to compare the effect of beer, red wine, whisky and their comparable pure ethanol solutions on gastric emptying in a controlled and randomized investigation.

METHODS

On separate days, 10 healthy, fasted subjects received the following solutions, in random order, through a gastric tube: 500 mL beer, red wine, comparable pure ethanol solutions (4% and 10% v/v), glucose (5.5% and 11.4% w/v) and water, 125 mL whisky and 40% (v/v) ethanol (both followed by 125 mL water) and 250 mL water. Gastric emptying of the test solutions was assessed using ultrasonography of the antrum.

RESULTS

As measured by ultrasonography of the antrum, half emptying times of the ethanol solutions (4%, 10% and 40% v/v) were significantly (P < 0.05) longer (22.6 +/- 4.8, 22.7 +/- 4.3 and 27.8 +/- 3.3 min, respectively, n=10) than those of water (14.6 +/- 1.9 min (500 mL) and 13.2 +/- 1.7 min (250 mL), respectively). The half emptying times of beer (39.3 +/- 4.3 min) and red wine (72.6 +/- 7.6 min) were significantly longer than those of the corresponding ethanol concentrations, whereas whisky was emptied at nearly the same rate (26.4 +/- 5.9 min) as 40% (v/v) ethanol. Emptying of glucose 5.5% and 11.4% (w/v) was significantly and dose dependently slower (29.7 +/- 4.5 and 64.8 +/- 8.9 min) than water.

CONCLUSIONS

1) Pure ethanol in concentrations of 4%, 10% and 40% (v/v) inhibits gastric emptying. 2) The inhibitory effect of beer and red wine, but not of whisky, is stronger than that of their comparable ethanol concentrations. 3) Caloric content and non-alcoholic ingredients in alcoholic beverages produced by fermentation (beer and wine), but not in those produced by distillation (whisky), are most likely responsible for this effect.

Authors+Show Affiliations

Department of Medicine II, University Hospital of Heidelberg at Mannheim, Theodor-Kutzer-Ufer 1-3, DE-68167 Mannheim, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15370684

Citation

Franke, A, et al. "Effect of Ethanol and some Alcoholic Beverages On Gastric Emptying in Humans." Scandinavian Journal of Gastroenterology, vol. 39, no. 7, 2004, pp. 638-44.
Franke A, Teyssen S, Harder H, et al. Effect of ethanol and some alcoholic beverages on gastric emptying in humans. Scand J Gastroenterol. 2004;39(7):638-44.
Franke, A., Teyssen, S., Harder, H., & Singer, M. V. (2004). Effect of ethanol and some alcoholic beverages on gastric emptying in humans. Scandinavian Journal of Gastroenterology, 39(7), 638-44.
Franke A, et al. Effect of Ethanol and some Alcoholic Beverages On Gastric Emptying in Humans. Scand J Gastroenterol. 2004;39(7):638-44. PubMed PMID: 15370684.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of ethanol and some alcoholic beverages on gastric emptying in humans. AU - Franke,A, AU - Teyssen,S, AU - Harder,H, AU - Singer,M V, PY - 2004/9/17/pubmed PY - 2005/4/6/medline PY - 2004/9/17/entrez SP - 638 EP - 44 JF - Scandinavian journal of gastroenterology JO - Scand J Gastroenterol VL - 39 IS - 7 N2 - BACKGROUND: There is a paucity of detailed and controlled studies on the action of ethanol and alcoholic beverages on gastric emptying in humans. This study was designed to compare the effect of beer, red wine, whisky and their comparable pure ethanol solutions on gastric emptying in a controlled and randomized investigation. METHODS: On separate days, 10 healthy, fasted subjects received the following solutions, in random order, through a gastric tube: 500 mL beer, red wine, comparable pure ethanol solutions (4% and 10% v/v), glucose (5.5% and 11.4% w/v) and water, 125 mL whisky and 40% (v/v) ethanol (both followed by 125 mL water) and 250 mL water. Gastric emptying of the test solutions was assessed using ultrasonography of the antrum. RESULTS: As measured by ultrasonography of the antrum, half emptying times of the ethanol solutions (4%, 10% and 40% v/v) were significantly (P < 0.05) longer (22.6 +/- 4.8, 22.7 +/- 4.3 and 27.8 +/- 3.3 min, respectively, n=10) than those of water (14.6 +/- 1.9 min (500 mL) and 13.2 +/- 1.7 min (250 mL), respectively). The half emptying times of beer (39.3 +/- 4.3 min) and red wine (72.6 +/- 7.6 min) were significantly longer than those of the corresponding ethanol concentrations, whereas whisky was emptied at nearly the same rate (26.4 +/- 5.9 min) as 40% (v/v) ethanol. Emptying of glucose 5.5% and 11.4% (w/v) was significantly and dose dependently slower (29.7 +/- 4.5 and 64.8 +/- 8.9 min) than water. CONCLUSIONS: 1) Pure ethanol in concentrations of 4%, 10% and 40% (v/v) inhibits gastric emptying. 2) The inhibitory effect of beer and red wine, but not of whisky, is stronger than that of their comparable ethanol concentrations. 3) Caloric content and non-alcoholic ingredients in alcoholic beverages produced by fermentation (beer and wine), but not in those produced by distillation (whisky), are most likely responsible for this effect. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/15370684/Effect_of_ethanol_and_some_alcoholic_beverages_on_gastric_emptying_in_humans_ L2 - https://www.tandfonline.com/doi/full/10.1080/00365520410005009 DB - PRIME DP - Unbound Medicine ER -