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Early-phase alcoholic liver disease: an update on animal models, pathology, and pathogenesis.
Int J Toxicol 2004 Jul-Aug; 23(4):217-31IJ

Abstract

Alcoholic liver disease (ALD) remains to be one of the most common etiology of liver disease and is a major cause of morbidity and mortality worldwide. The pathologic stages of ALD comprises of steatosis, steatohepatitis, and fibrosis/cirrhosis. Steatosis and steatohepatitis represents the early phase of ALD and are precursor stages for fibrosis/cirrhosis. Numerous research efforts have been directed at recognizing cofactors interacting with alcohol in the pathogenesis of steatosis and steatohepatitis. This review will elucidate the constellation of complex pathogenesis, available animal models, and microscopic pathologic findings mostly in the early-phase of ALD. The role of endotoxin, reactive oxygen species, alcohol metabolism, and cytokines are discussed. Understanding the mechanisms of early-phase ALD should provide insight into the development of therapeutic strategies and thereby decrease the morbidity and mortality associated with ALD.

Authors+Show Affiliations

Department of Pathobiology, Texas Veterinary Medical Center, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

15371166

Citation

Ramaiah, Shashi, et al. "Early-phase Alcoholic Liver Disease: an Update On Animal Models, Pathology, and Pathogenesis." International Journal of Toxicology, vol. 23, no. 4, 2004, pp. 217-31.
Ramaiah S, Rivera C, Arteel G. Early-phase alcoholic liver disease: an update on animal models, pathology, and pathogenesis. Int J Toxicol. 2004;23(4):217-31.
Ramaiah, S., Rivera, C., & Arteel, G. (2004). Early-phase alcoholic liver disease: an update on animal models, pathology, and pathogenesis. International Journal of Toxicology, 23(4), pp. 217-31.
Ramaiah S, Rivera C, Arteel G. Early-phase Alcoholic Liver Disease: an Update On Animal Models, Pathology, and Pathogenesis. Int J Toxicol. 2004;23(4):217-31. PubMed PMID: 15371166.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early-phase alcoholic liver disease: an update on animal models, pathology, and pathogenesis. AU - Ramaiah,Shashi, AU - Rivera,Chantal, AU - Arteel,Gavin, PY - 2004/9/17/pubmed PY - 2005/2/16/medline PY - 2004/9/17/entrez SP - 217 EP - 31 JF - International journal of toxicology JO - Int. J. Toxicol. VL - 23 IS - 4 N2 - Alcoholic liver disease (ALD) remains to be one of the most common etiology of liver disease and is a major cause of morbidity and mortality worldwide. The pathologic stages of ALD comprises of steatosis, steatohepatitis, and fibrosis/cirrhosis. Steatosis and steatohepatitis represents the early phase of ALD and are precursor stages for fibrosis/cirrhosis. Numerous research efforts have been directed at recognizing cofactors interacting with alcohol in the pathogenesis of steatosis and steatohepatitis. This review will elucidate the constellation of complex pathogenesis, available animal models, and microscopic pathologic findings mostly in the early-phase of ALD. The role of endotoxin, reactive oxygen species, alcohol metabolism, and cytokines are discussed. Understanding the mechanisms of early-phase ALD should provide insight into the development of therapeutic strategies and thereby decrease the morbidity and mortality associated with ALD. SN - 1091-5818 UR - https://www.unboundmedicine.com/medline/citation/15371166/Early_phase_alcoholic_liver_disease:_an_update_on_animal_models_pathology_and_pathogenesis_ L2 - http://journals.sagepub.com/doi/full/10.1080/10915810490502069?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -