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The cardiovascular actions of protease-activated receptors.
Mol Pharmacol. 2005 Jan; 67(1):2-11.MP

Abstract

Protease-activated receptors (PARs) comprise a family of G protein-coupled receptors with a unique proteolytic activation mechanism. PARs are activated by thrombin or other coagulation or inflammatory proteases formed at sites of tissue injury. PARs play a particularly important role in the pathogenesis of clinical disorders characterized by chronic inflammation or smoldering activation of the coagulation cascade. Individual PARs have been linked to the regulation of a broad range of cellular functions. Recent studies identify PAR family members in the vasculature (including within atherosclerotic lesions) and in the heart. Here, PAR-triggered responses contribute to vasoregulation and influence cardiac electrical and mechanical activity. PAR activation also is linked to structural remodeling of the vasculature and the myocardium. This review focuses on the cardiovascular actions of PARs that play a role in normal cardiovascular physiology and that are likely to contribute to cardiovascular diseases.

Authors+Show Affiliations

Department of Pharmacology, College of Physicians and Surgeons, Columbia University, 630 West 168 Street, New York, NY 10032, USA. sfs1@columbia.edu

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

15371558

Citation

Steinberg, Susan F.. "The Cardiovascular Actions of Protease-activated Receptors." Molecular Pharmacology, vol. 67, no. 1, 2005, pp. 2-11.
Steinberg SF. The cardiovascular actions of protease-activated receptors. Mol Pharmacol. 2005;67(1):2-11.
Steinberg, S. F. (2005). The cardiovascular actions of protease-activated receptors. Molecular Pharmacology, 67(1), 2-11.
Steinberg SF. The Cardiovascular Actions of Protease-activated Receptors. Mol Pharmacol. 2005;67(1):2-11. PubMed PMID: 15371558.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The cardiovascular actions of protease-activated receptors. A1 - Steinberg,Susan F, Y1 - 2004/09/15/ PY - 2004/9/17/pubmed PY - 2005/3/29/medline PY - 2004/9/17/entrez SP - 2 EP - 11 JF - Molecular pharmacology JO - Mol Pharmacol VL - 67 IS - 1 N2 - Protease-activated receptors (PARs) comprise a family of G protein-coupled receptors with a unique proteolytic activation mechanism. PARs are activated by thrombin or other coagulation or inflammatory proteases formed at sites of tissue injury. PARs play a particularly important role in the pathogenesis of clinical disorders characterized by chronic inflammation or smoldering activation of the coagulation cascade. Individual PARs have been linked to the regulation of a broad range of cellular functions. Recent studies identify PAR family members in the vasculature (including within atherosclerotic lesions) and in the heart. Here, PAR-triggered responses contribute to vasoregulation and influence cardiac electrical and mechanical activity. PAR activation also is linked to structural remodeling of the vasculature and the myocardium. This review focuses on the cardiovascular actions of PARs that play a role in normal cardiovascular physiology and that are likely to contribute to cardiovascular diseases. SN - 0026-895X UR - https://www.unboundmedicine.com/medline/citation/15371558/The_cardiovascular_actions_of_protease_activated_receptors_ L2 - http://molpharm.aspetjournals.org/cgi/pmidlookup?view=long&pmid=15371558 DB - PRIME DP - Unbound Medicine ER -