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Perceived health-related quality of life and comorbidity in diabetic patients starting dialysis (CALVIDIA study).
J Nephrol. 2004 Jul-Aug; 17(4):544-51.JN

Abstract

BACKGROUND

Diabetes mellitus (DM) is a widespread prevalent illness, currently the main cause of end-stage renal disease (ESRD).

MATERIAL AND METHODS

In a longitudinal, prospective study we compared two cohorts of patients starting dialysis therapy, diabetic and non-diabetic ESRD patients. Perceived health was measured by the Medical Outcomes Study Short-Form 36 (SF-36) questionnaire, functional status by the Karnofsky scale and comorbidity by the Charlson age-comorbidity index. A broad spectrum of variables in relation to diabetes, ESRD, comorbidity and renal replacement therapy (RRT) were studied, as well as the distribution of comorbidity frequencies at dialysis start.

RESULTS

Thirty-four Spanish centers included 232 diabetic patients, 43 type 1 and 189 type 2, mean diabetes duration 18 +/- 9 yrs, and five centers included 121 non-diabetic patients. Out of the 232 diabetic patients, 187 patients (81%) started hemodialysis (HD) and 45 patients (19%) started peritoneal dialysis (PD) (vs. 82% and 18%, respectively in non-diabetic patients). Transient vascular access (VA) for starting RRT was required in 54% of the diabetic patients vs. 53% in the nondiabetic patients. When both study groups were compared, diabetic patients required antihypertensive drugs more frequently than non-diabetic patients and showed higher systolic blood pressure (BP), as well as higher cardiovascular (CV) complication incidences, poorer SF-36 physical component summary scores and mental component summary scores and worse Karnofsky scale scores, with the Charlson age-comorbidity score being higher.

CONCLUSION

Diabetic patients starting dialysis in Spain are more often type 2 diabetics, have worse perceived health-related quality of life (HRQoL) in relation to non-diabetic patients, worse functional status and higher incidences of prognostic mortality markers.

Authors+Show Affiliations

Department of Nephrology, Bellvitge Hospital, University of Barcelona, Barcelona, Spain. amcastel@terra.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15372417

Citation

Martínez-Castelao, Alberto, et al. "Perceived Health-related Quality of Life and Comorbidity in Diabetic Patients Starting Dialysis (CALVIDIA Study)." Journal of Nephrology, vol. 17, no. 4, 2004, pp. 544-51.
Martínez-Castelao A, Gòrriz JL, Garcia-López F, et al. Perceived health-related quality of life and comorbidity in diabetic patients starting dialysis (CALVIDIA study). J Nephrol. 2004;17(4):544-51.
Martínez-Castelao, A., Gòrriz, J. L., Garcia-López, F., López-Revuelta, K., De Alvaro, F., & Cruzado, J. M. (2004). Perceived health-related quality of life and comorbidity in diabetic patients starting dialysis (CALVIDIA study). Journal of Nephrology, 17(4), 544-51.
Martínez-Castelao A, et al. Perceived Health-related Quality of Life and Comorbidity in Diabetic Patients Starting Dialysis (CALVIDIA Study). J Nephrol. 2004 Jul-Aug;17(4):544-51. PubMed PMID: 15372417.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Perceived health-related quality of life and comorbidity in diabetic patients starting dialysis (CALVIDIA study). AU - Martínez-Castelao,Alberto, AU - Gòrriz,José Luis, AU - Garcia-López,Fernando, AU - López-Revuelta,Katia, AU - De Alvaro,Fernando, AU - Cruzado,Josep M, AU - ,, PY - 2004/9/17/pubmed PY - 2004/12/24/medline PY - 2004/9/17/entrez SP - 544 EP - 51 JF - Journal of nephrology JO - J. Nephrol. VL - 17 IS - 4 N2 - BACKGROUND: Diabetes mellitus (DM) is a widespread prevalent illness, currently the main cause of end-stage renal disease (ESRD). MATERIAL AND METHODS: In a longitudinal, prospective study we compared two cohorts of patients starting dialysis therapy, diabetic and non-diabetic ESRD patients. Perceived health was measured by the Medical Outcomes Study Short-Form 36 (SF-36) questionnaire, functional status by the Karnofsky scale and comorbidity by the Charlson age-comorbidity index. A broad spectrum of variables in relation to diabetes, ESRD, comorbidity and renal replacement therapy (RRT) were studied, as well as the distribution of comorbidity frequencies at dialysis start. RESULTS: Thirty-four Spanish centers included 232 diabetic patients, 43 type 1 and 189 type 2, mean diabetes duration 18 +/- 9 yrs, and five centers included 121 non-diabetic patients. Out of the 232 diabetic patients, 187 patients (81%) started hemodialysis (HD) and 45 patients (19%) started peritoneal dialysis (PD) (vs. 82% and 18%, respectively in non-diabetic patients). Transient vascular access (VA) for starting RRT was required in 54% of the diabetic patients vs. 53% in the nondiabetic patients. When both study groups were compared, diabetic patients required antihypertensive drugs more frequently than non-diabetic patients and showed higher systolic blood pressure (BP), as well as higher cardiovascular (CV) complication incidences, poorer SF-36 physical component summary scores and mental component summary scores and worse Karnofsky scale scores, with the Charlson age-comorbidity score being higher. CONCLUSION: Diabetic patients starting dialysis in Spain are more often type 2 diabetics, have worse perceived health-related quality of life (HRQoL) in relation to non-diabetic patients, worse functional status and higher incidences of prognostic mortality markers. SN - 1121-8428 UR - https://www.unboundmedicine.com/medline/citation/15372417/Perceived_health_related_quality_of_life_and_comorbidity_in_diabetic_patients_starting_dialysis__CALVIDIA_study__ L2 - https://medlineplus.gov/kidneyfailure.html DB - PRIME DP - Unbound Medicine ER -