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[Cardiovascular risk factors in the circadian rhythm of acute myocardial infarction].
Rev Esp Cardiol. 2004 Sep; 57(9):850-8.RE

Abstract

INTRODUCTION AND OBJECTIVES

The aim of this study was to analyze the influence of modifiable cardiovascular risk factors on the circadian rhythm of acute myocardial infarction.

PATIENTS AND METHOD

We analyzed a retrospective cohort of 54,249 patients from a multicenter study of acute myocardial infarction (the Spanish ARIAM study). The variables were time of onset of symptoms, age, sex, previous ischemic heart disease, coronary unit discharge status, previous stroke, familial antecedents of ischemic heart disease, hypertension, diabetes, dyslipidemia, smoking, and reinfarction. To verify the presence of circadian rhythm, we developed a simple test of equality of time series based on cosinor analysis of multiple sinusoid curves. Three sinusoids (24, 12 and 8 hour periods) were used.

RESULTS

The time of onset of pain showed a circadian rhythm (P< .01), with a peak at 10:07 am and a trough at 4:46 am. All subgroups categorized according to the presence of the variables analyzed here showed a circadian rhythm, with a sinusoid curve after adjustment. In patients with diabetes or reinfarction or who were smokers, the sinusoid curve was bimodal.

CONCLUSIONS

Time of onset of symptoms in patients with acute myocardial infarction follows a circadian rhythm. Diabetes, smoking and reinfarction can modify the standard circadian rhythm of onset of myocardial infarction.

Authors+Show Affiliations

López Messa JB
Unidad de Cuidados Intensivos, Hospital Río Carrión, Palencia, Spain. jlomessa@telefonica.net
Garmendia Leiza JR
No affiliation info available
Aguilar García MD
No affiliation info available
Andrés de Llano JM
No affiliation info available
Alberola López C
No affiliation info available
Ardura Fernández J
No affiliation info available
Grupo de Estudio ARIAM
No affiliation info available

MeSH

AgedCircadian RhythmFemaleHumansMaleMyocardial InfarctionRetrospective StudiesRisk FactorsSpain

Pub Type(s)

Comparative Study
English Abstract
Journal Article
Multicenter Study

Language

spa

PubMed ID

15373991

Citation

López Messa, Juan B., et al. "[Cardiovascular Risk Factors in the Circadian Rhythm of Acute Myocardial Infarction]." Revista Espanola De Cardiologia, vol. 57, no. 9, 2004, pp. 850-8.
López Messa JB, Garmendia Leiza JR, Aguilar García MD, et al. [Cardiovascular risk factors in the circadian rhythm of acute myocardial infarction]. Rev Esp Cardiol. 2004;57(9):850-8.
López Messa, J. B., Garmendia Leiza, J. R., Aguilar García, M. D., Andrés de Llano, J. M., Alberola López, C., & Ardura Fernández, J. (2004). [Cardiovascular risk factors in the circadian rhythm of acute myocardial infarction]. Revista Espanola De Cardiologia, 57(9), 850-8.
López Messa JB, et al. [Cardiovascular Risk Factors in the Circadian Rhythm of Acute Myocardial Infarction]. Rev Esp Cardiol. 2004;57(9):850-8. PubMed PMID: 15373991.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Cardiovascular risk factors in the circadian rhythm of acute myocardial infarction]. AU - López Messa,Juan B, AU - Garmendia Leiza,José R, AU - Aguilar García,María D, AU - Andrés de Llano,Jesús M, AU - Alberola López,Carlos, AU - Ardura Fernández,Julio, AU - ,, PY - 2004/9/18/pubmed PY - 2004/12/16/medline PY - 2004/9/18/entrez SP - 850 EP - 8 JF - Revista espanola de cardiologia JO - Rev Esp Cardiol VL - 57 IS - 9 N2 - INTRODUCTION AND OBJECTIVES: The aim of this study was to analyze the influence of modifiable cardiovascular risk factors on the circadian rhythm of acute myocardial infarction. PATIENTS AND METHOD: We analyzed a retrospective cohort of 54,249 patients from a multicenter study of acute myocardial infarction (the Spanish ARIAM study). The variables were time of onset of symptoms, age, sex, previous ischemic heart disease, coronary unit discharge status, previous stroke, familial antecedents of ischemic heart disease, hypertension, diabetes, dyslipidemia, smoking, and reinfarction. To verify the presence of circadian rhythm, we developed a simple test of equality of time series based on cosinor analysis of multiple sinusoid curves. Three sinusoids (24, 12 and 8 hour periods) were used. RESULTS: The time of onset of pain showed a circadian rhythm (P< .01), with a peak at 10:07 am and a trough at 4:46 am. All subgroups categorized according to the presence of the variables analyzed here showed a circadian rhythm, with a sinusoid curve after adjustment. In patients with diabetes or reinfarction or who were smokers, the sinusoid curve was bimodal. CONCLUSIONS: Time of onset of symptoms in patients with acute myocardial infarction follows a circadian rhythm. Diabetes, smoking and reinfarction can modify the standard circadian rhythm of onset of myocardial infarction. SN - 0300-8932 UR - https://www.unboundmedicine.com/medline/citation/15373991/[Cardiovascular_risk_factors_in_the_circadian_rhythm_of_acute_myocardial_infarction]_ DB - PRIME DP - Unbound Medicine ER -