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Overexpression of Ang-2 mRNA in non-small cell lung cancer: association with angiogenesis and poor prognosis.
Oncol Rep. 2004 Oct; 12(4):849-53.OR

Abstract

Overexpressed Angiopoietin-2 (Ang-2) derived mainly from cancer cells was reported to promote tumor angiogenesis. The aim of this study was to evaluate the expression of Ang-2 in non-small cell lung cancers (NSCLCs). We investigated Ang-2 expression in 77 patients with NSCLC who underwent curative tumor resection by means of reverse transcription-polymerase chain reaction (RT-PCR). We also determined whether or not expression of Ang-2 mRNA correlates with immunohistochemical assays of Ang-2 protein and microvessel density (MVD) level. The level of Ang-2 mRNA expression was presented by the relative yield of each gene to the S14 mRNA, respectively. Ang-2 mRNA expression in NSCLC was significantly greater than that in non-cancerous normal lung (p=0.0178). The Ang-2 mRNA expression was significantly associated with lymph node metastasis, stage, Ang-2 protein, and microvessel density (MVD) level (p=0.0009 for lymph node metastasis; p=0.0002 for stage; p<0.0001 for Ang-2 protein; p<0.0001 for MVD). With regard to prognosis, the overall and stage I survival rates for patients in the high Ang-2 mRNA expression group were significantly poorer when compared with the low Ang-2 mRNA expression group (p<0.0001 for overall; p=0.0201 for stage I). Furthermore, expression of Ang-2 mRNA was an independent predictor of prognosis by multivariate analysis (p=0.0028). These data indicate that Ang-2 may contribute to tumor angiogenesis and progression and that Ang-2 gene expression can serve as a useful prognostic marker in NSCLC.

Authors+Show Affiliations

Department of Surgery, Teikyo University School of Medicine, Tokyo 173, Japan. takanami@med.teikyo-u.ac.jp

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15375511

Citation

Takanami, Iwao. "Overexpression of Ang-2 mRNA in Non-small Cell Lung Cancer: Association With Angiogenesis and Poor Prognosis." Oncology Reports, vol. 12, no. 4, 2004, pp. 849-53.
Takanami I. Overexpression of Ang-2 mRNA in non-small cell lung cancer: association with angiogenesis and poor prognosis. Oncol Rep. 2004;12(4):849-53.
Takanami, I. (2004). Overexpression of Ang-2 mRNA in non-small cell lung cancer: association with angiogenesis and poor prognosis. Oncology Reports, 12(4), 849-53.
Takanami I. Overexpression of Ang-2 mRNA in Non-small Cell Lung Cancer: Association With Angiogenesis and Poor Prognosis. Oncol Rep. 2004;12(4):849-53. PubMed PMID: 15375511.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Overexpression of Ang-2 mRNA in non-small cell lung cancer: association with angiogenesis and poor prognosis. A1 - Takanami,Iwao, PY - 2004/9/18/pubmed PY - 2005/3/16/medline PY - 2004/9/18/entrez SP - 849 EP - 53 JF - Oncology reports JO - Oncol Rep VL - 12 IS - 4 N2 - Overexpressed Angiopoietin-2 (Ang-2) derived mainly from cancer cells was reported to promote tumor angiogenesis. The aim of this study was to evaluate the expression of Ang-2 in non-small cell lung cancers (NSCLCs). We investigated Ang-2 expression in 77 patients with NSCLC who underwent curative tumor resection by means of reverse transcription-polymerase chain reaction (RT-PCR). We also determined whether or not expression of Ang-2 mRNA correlates with immunohistochemical assays of Ang-2 protein and microvessel density (MVD) level. The level of Ang-2 mRNA expression was presented by the relative yield of each gene to the S14 mRNA, respectively. Ang-2 mRNA expression in NSCLC was significantly greater than that in non-cancerous normal lung (p=0.0178). The Ang-2 mRNA expression was significantly associated with lymph node metastasis, stage, Ang-2 protein, and microvessel density (MVD) level (p=0.0009 for lymph node metastasis; p=0.0002 for stage; p<0.0001 for Ang-2 protein; p<0.0001 for MVD). With regard to prognosis, the overall and stage I survival rates for patients in the high Ang-2 mRNA expression group were significantly poorer when compared with the low Ang-2 mRNA expression group (p<0.0001 for overall; p=0.0201 for stage I). Furthermore, expression of Ang-2 mRNA was an independent predictor of prognosis by multivariate analysis (p=0.0028). These data indicate that Ang-2 may contribute to tumor angiogenesis and progression and that Ang-2 gene expression can serve as a useful prognostic marker in NSCLC. SN - 1021-335X UR - https://www.unboundmedicine.com/medline/citation/15375511/Overexpression_of_Ang_2_mRNA_in_non_small_cell_lung_cancer:_association_with_angiogenesis_and_poor_prognosis_ L2 - http://www.spandidos-publications.com/or/12/4/849 DB - PRIME DP - Unbound Medicine ER -