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Association of HNPCC and endometrial cancers.
Int J Clin Oncol. 2004 Aug; 9(4):262-9.IJ

Abstract

Hereditary nonpolyposis colorectal cancer (HNPCC) is among the representative familial cancers that are autosomally dominant inherited disorders. Because endometrial cancers develop at high rates in women with HNPCC, it is suggested that some endometrial cancers are familial cancers that are induced by mutations of the DNA mismatch repair (MMR) genes, as in HNPCC. To understand the clinical pathology of familial endometrial cancers that are associated with HNPCC, we surveyed the family histories of 385 patients with endometrial cancer and found that 0.5% of endometrial cancers met the new diagnostic criteria of HNPCC. From molecular and biological analyses, we found microsatellite instability in 30.8% of endometrial cancers and germline mutations of MMR genes in 8.3%. These results suggest a close relationship of MMR gene mutations to the development of endometrial cancers. For a better understanding of the clinical pathology of HNPCC-associated familial endometrial cancers, it is critical for gynecologists to perform a large multicenter study, including detailed family histories.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan. kbanno@sc.itc.keio.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15375702

Citation

Banno, Kouji, et al. "Association of HNPCC and Endometrial Cancers." International Journal of Clinical Oncology, vol. 9, no. 4, 2004, pp. 262-9.
Banno K, Susumu N, Yanokura M, et al. Association of HNPCC and endometrial cancers. Int J Clin Oncol. 2004;9(4):262-9.
Banno, K., Susumu, N., Yanokura, M., Hirao, T., Iwata, T., Hirasawa, A., Aoki, D., Sugano, K., & Nozawa, S. (2004). Association of HNPCC and endometrial cancers. International Journal of Clinical Oncology, 9(4), 262-9.
Banno K, et al. Association of HNPCC and Endometrial Cancers. Int J Clin Oncol. 2004;9(4):262-9. PubMed PMID: 15375702.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of HNPCC and endometrial cancers. AU - Banno,Kouji, AU - Susumu,Nobuyuki, AU - Yanokura,Megumi, AU - Hirao,Takeshi, AU - Iwata,Takashi, AU - Hirasawa,Akira, AU - Aoki,Daisuke, AU - Sugano,Kokichi, AU - Nozawa,Shiro, PY - 2004/03/10/received PY - 2004/9/18/pubmed PY - 2004/12/16/medline PY - 2004/9/18/entrez SP - 262 EP - 9 JF - International journal of clinical oncology JO - Int J Clin Oncol VL - 9 IS - 4 N2 - Hereditary nonpolyposis colorectal cancer (HNPCC) is among the representative familial cancers that are autosomally dominant inherited disorders. Because endometrial cancers develop at high rates in women with HNPCC, it is suggested that some endometrial cancers are familial cancers that are induced by mutations of the DNA mismatch repair (MMR) genes, as in HNPCC. To understand the clinical pathology of familial endometrial cancers that are associated with HNPCC, we surveyed the family histories of 385 patients with endometrial cancer and found that 0.5% of endometrial cancers met the new diagnostic criteria of HNPCC. From molecular and biological analyses, we found microsatellite instability in 30.8% of endometrial cancers and germline mutations of MMR genes in 8.3%. These results suggest a close relationship of MMR gene mutations to the development of endometrial cancers. For a better understanding of the clinical pathology of HNPCC-associated familial endometrial cancers, it is critical for gynecologists to perform a large multicenter study, including detailed family histories. SN - 1341-9625 UR - https://www.unboundmedicine.com/medline/citation/15375702/Association_of_HNPCC_and_endometrial_cancers_ L2 - http://dx.doi.org/10.1007/s10147-004-0402-8 DB - PRIME DP - Unbound Medicine ER -