Tags

Type your tag names separated by a space and hit enter

Terminalia arjuna reverses impaired endothelial function in chronic smokers.
Indian Heart J 2004 Mar-Apr; 56(2):123-8IH

Abstract

BACKGROUND

Smoking, largely through increased oxidative stress, causes endothelial dysfunction which is an early key event in atherosclerosis. Smoking cessation and antioxidant vitamin therapy are shown to have beneficial role by restoring altered endothelial physiology. The present study was aimed to determine whether Terminalia arjuna, an Indian medicinal plant with potent antioxidant constituents, would improve endothelial dysfunction in smokers.

METHODS AND RESULTS

Eighteen healthy male smokers (age 28.16+/-9.45 years) and equal number of age-matched non-smoker controls participated in the study. The baseline brachial artery reactivity studies were performed using high frequency ultrasound according to standard protocol under identical conditions to determine endothelium-dependent, flow-mediated dilation and endothelium-independent nitroglycerine-mediated dilation. The two groups were matched regarding age, body mass index, blood pressure, serum cholesterol, mean resting vessel diameters and post-occlusion flow velocities (all p=NS). While flow-mediated dilation was significantly impaired amongst smokers compared to controls (4.71+/-2.22 v. 11.75+/-5.94%, p <0.005), the nitroglycerine-mediated dilation was similar in the two groups (20.35+/-3.89 v. 19.68+/-3.74%, p=NS). Subsequently the smokers were given Terminalia arjuna (500 mg q8h) or matching placebo randomly in a double blind cross-over design for two weeks each, followed by repetition of brachial artery reactivity studies to determine various parameters including flow-mediated dilation after each period. There was no significant difference as regards vessel diameter and flow velocities between the two therapies. However, the flow-mediated dilation showed significant improvement from baseline values after Terrminalia arjuna therapy but not with placebo (9.31+/-3.74 v. 5.17+/-2.42%, p <0.005).

CONCLUSIONS

Smokers have impaired endothelium-dependent but normal endothelium-independent vasodilation as determined by brachial artery reactivity studies. Further, Terrminalia arjuna therapy for two weeks leads to significant regression of this endothelial abnormality amongst smokers.

Authors+Show Affiliations

Division of Cardiology, Department of Medicine, Mahatma Gandhi Memorial Medical College and Maharaja Yashwant Rao Hospital, Indore. tanmaybharani@eth.netNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15377133

Citation

Bharani, Anil, et al. "Terminalia Arjuna Reverses Impaired Endothelial Function in Chronic Smokers." Indian Heart Journal, vol. 56, no. 2, 2004, pp. 123-8.
Bharani A, Ahirwar LK, Jain N. Terminalia arjuna reverses impaired endothelial function in chronic smokers. Indian Heart J. 2004;56(2):123-8.
Bharani, A., Ahirwar, L. K., & Jain, N. (2004). Terminalia arjuna reverses impaired endothelial function in chronic smokers. Indian Heart Journal, 56(2), pp. 123-8.
Bharani A, Ahirwar LK, Jain N. Terminalia Arjuna Reverses Impaired Endothelial Function in Chronic Smokers. Indian Heart J. 2004;56(2):123-8. PubMed PMID: 15377133.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Terminalia arjuna reverses impaired endothelial function in chronic smokers. AU - Bharani,Anil, AU - Ahirwar,Lalit Kumar, AU - Jain,Neeraj, PY - 2004/9/21/pubmed PY - 2004/10/20/medline PY - 2004/9/21/entrez SP - 123 EP - 8 JF - Indian heart journal JO - Indian Heart J VL - 56 IS - 2 N2 - BACKGROUND: Smoking, largely through increased oxidative stress, causes endothelial dysfunction which is an early key event in atherosclerosis. Smoking cessation and antioxidant vitamin therapy are shown to have beneficial role by restoring altered endothelial physiology. The present study was aimed to determine whether Terminalia arjuna, an Indian medicinal plant with potent antioxidant constituents, would improve endothelial dysfunction in smokers. METHODS AND RESULTS: Eighteen healthy male smokers (age 28.16+/-9.45 years) and equal number of age-matched non-smoker controls participated in the study. The baseline brachial artery reactivity studies were performed using high frequency ultrasound according to standard protocol under identical conditions to determine endothelium-dependent, flow-mediated dilation and endothelium-independent nitroglycerine-mediated dilation. The two groups were matched regarding age, body mass index, blood pressure, serum cholesterol, mean resting vessel diameters and post-occlusion flow velocities (all p=NS). While flow-mediated dilation was significantly impaired amongst smokers compared to controls (4.71+/-2.22 v. 11.75+/-5.94%, p <0.005), the nitroglycerine-mediated dilation was similar in the two groups (20.35+/-3.89 v. 19.68+/-3.74%, p=NS). Subsequently the smokers were given Terminalia arjuna (500 mg q8h) or matching placebo randomly in a double blind cross-over design for two weeks each, followed by repetition of brachial artery reactivity studies to determine various parameters including flow-mediated dilation after each period. There was no significant difference as regards vessel diameter and flow velocities between the two therapies. However, the flow-mediated dilation showed significant improvement from baseline values after Terrminalia arjuna therapy but not with placebo (9.31+/-3.74 v. 5.17+/-2.42%, p <0.005). CONCLUSIONS: Smokers have impaired endothelium-dependent but normal endothelium-independent vasodilation as determined by brachial artery reactivity studies. Further, Terrminalia arjuna therapy for two weeks leads to significant regression of this endothelial abnormality amongst smokers. SN - 0019-4832 UR - https://www.unboundmedicine.com/medline/citation/15377133/Terminalia_arjuna_reverses_impaired_endothelial_function_in_chronic_smokers_ L2 - https://medlineplus.gov/herbalmedicine.html DB - PRIME DP - Unbound Medicine ER -