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Expression of multidrug resistance-related markers in primary neuroblastoma.
Chin Med J (Engl). 2004 Sep; 117(9):1358-63.CM

Abstract

BACKGROUND

Multidrug resistance is associated with a poor prognosis in various human cancers. However, the clinical significance of the expression of multidrug resistance-related markers in neuroblastoma is still on debate. In this study, the effect of the expression of p-glycoprotein (P-gp), multidrug resistance-associated protein (MRP), and lung resistance protein (LRP) in neuroblastoma was evaluated.

METHODS

The streptavidin-biotin immunoperoxidase (SP) technique was used to evaluate the expression of P-gp, MRP, and LRP in 70 cases of untreated primary neuroblastoma.

RESULTS

The frequencies of the expression of P-gp, MRP, and LRP were 61.4%, 38.6%, and 24.3%, respectively. A significant positive correlation was observed between P-gp and MRP expression (P=0.001), as well as between LRP and MRP expression (P=0.01). The rates of expression of P-gp and MRP were higher in tumors from patients aged greater than one year old than in tumors from patients aged less than 1 year old at time of diagnosis (P=0.01 and 0.018, respectively). MRP expression in tumors that had metastasized was significantly more frequent than in tumors that had not metastasized (P=0.015). The expression of all tested proteins showed a significant relationship with whether or not the tumor had differentiated (P=0.006, 0.000 or 0.001, respectively). MRP expression was significantly associated with a reduction in both median survival time and 2-year cumulative survival (P=0.02). By contrast, P-gp and MRP expression did not correlate with survival. According to Cox regression analysis, only the co-expression of P-gp and MRP had significant prognostic value (relative hazard, 3.513, P=0.033).

CONCLUSIONS

The intrinsic, multidrug resistance of neuroblastoma involves the combined effects of P-gp, MRP, and LRP. MRP expression may be an important factor determining prognosis in neuroblastoma.

Authors+Show Affiliations

Department of Pathology, No. 2 Clinical College, China Medical University, Shenyang 110004, China. lvqjie@163.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15377429

Citation

Lu, Qing-jie, et al. "Expression of Multidrug Resistance-related Markers in Primary Neuroblastoma." Chinese Medical Journal, vol. 117, no. 9, 2004, pp. 1358-63.
Lu QJ, Dong F, Zhang JH, et al. Expression of multidrug resistance-related markers in primary neuroblastoma. Chin Med J (Engl). 2004;117(9):1358-63.
Lu, Q. J., Dong, F., Zhang, J. H., Li, X. H., Ma, Y., & Jiang, W. G. (2004). Expression of multidrug resistance-related markers in primary neuroblastoma. Chinese Medical Journal, 117(9), 1358-63.
Lu QJ, et al. Expression of Multidrug Resistance-related Markers in Primary Neuroblastoma. Chin Med J (Engl). 2004;117(9):1358-63. PubMed PMID: 15377429.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Expression of multidrug resistance-related markers in primary neuroblastoma. AU - Lu,Qing-jie, AU - Dong,Fang, AU - Zhang,Jin-hua, AU - Li,Xiao-han, AU - Ma,Ying, AU - Jiang,Wei-guo, PY - 2004/9/21/pubmed PY - 2004/12/16/medline PY - 2004/9/21/entrez SP - 1358 EP - 63 JF - Chinese medical journal JO - Chin Med J (Engl) VL - 117 IS - 9 N2 - BACKGROUND: Multidrug resistance is associated with a poor prognosis in various human cancers. However, the clinical significance of the expression of multidrug resistance-related markers in neuroblastoma is still on debate. In this study, the effect of the expression of p-glycoprotein (P-gp), multidrug resistance-associated protein (MRP), and lung resistance protein (LRP) in neuroblastoma was evaluated. METHODS: The streptavidin-biotin immunoperoxidase (SP) technique was used to evaluate the expression of P-gp, MRP, and LRP in 70 cases of untreated primary neuroblastoma. RESULTS: The frequencies of the expression of P-gp, MRP, and LRP were 61.4%, 38.6%, and 24.3%, respectively. A significant positive correlation was observed between P-gp and MRP expression (P=0.001), as well as between LRP and MRP expression (P=0.01). The rates of expression of P-gp and MRP were higher in tumors from patients aged greater than one year old than in tumors from patients aged less than 1 year old at time of diagnosis (P=0.01 and 0.018, respectively). MRP expression in tumors that had metastasized was significantly more frequent than in tumors that had not metastasized (P=0.015). The expression of all tested proteins showed a significant relationship with whether or not the tumor had differentiated (P=0.006, 0.000 or 0.001, respectively). MRP expression was significantly associated with a reduction in both median survival time and 2-year cumulative survival (P=0.02). By contrast, P-gp and MRP expression did not correlate with survival. According to Cox regression analysis, only the co-expression of P-gp and MRP had significant prognostic value (relative hazard, 3.513, P=0.033). CONCLUSIONS: The intrinsic, multidrug resistance of neuroblastoma involves the combined effects of P-gp, MRP, and LRP. MRP expression may be an important factor determining prognosis in neuroblastoma. SN - 0366-6999 UR - https://www.unboundmedicine.com/medline/citation/15377429/Expression_of_multidrug_resistance_related_markers_in_primary_neuroblastoma_ L2 - https://www.diseaseinfosearch.org/result/5160 DB - PRIME DP - Unbound Medicine ER -