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Mitochondrial dysfunction and oxidative damage in Alzheimer's and Parkinson's diseases and coenzyme Q10 as a potential treatment.
J Bioenerg Biomembr. 2004 Aug; 36(4):381-6.JB

Abstract

There is substantial evidence that mitochondrial dysfunction and oxidative damage may play a key role in the pathogenesis of neurodegenerative disease. Evidence supporting this in both Alzheimer's and Parkinson's diseases is continuing to accumulate. This review discusses the increasing evidence for a role of both mitochondrial dysfunction and oxidative damage in contributing to beta-amyloid deposition in Alzheimer's disease. I also discuss the increasing evidence that Parkinson's disease is associated with abnormalities in the electron transport gene as well as oxidative damage. Lastly, I reviewed the potential efficacy of coenzyme Q as well as a number of other antioxidants in the treatment of both Parkinson's and Alzheimer's diseases.

Authors+Show Affiliations

Department of Neurology and Neuroscience, New York Presbyterian Hospital-Weill Medical College of Cornell University, 525 East 68th Street, New York, New York 10021, USA. fbeal@med.cornell.edu

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

15377876

Citation

Beal, M Flint. "Mitochondrial Dysfunction and Oxidative Damage in Alzheimer's and Parkinson's Diseases and Coenzyme Q10 as a Potential Treatment." Journal of Bioenergetics and Biomembranes, vol. 36, no. 4, 2004, pp. 381-6.
Beal MF. Mitochondrial dysfunction and oxidative damage in Alzheimer's and Parkinson's diseases and coenzyme Q10 as a potential treatment. J Bioenerg Biomembr. 2004;36(4):381-6.
Beal, M. F. (2004). Mitochondrial dysfunction and oxidative damage in Alzheimer's and Parkinson's diseases and coenzyme Q10 as a potential treatment. Journal of Bioenergetics and Biomembranes, 36(4), 381-6.
Beal MF. Mitochondrial Dysfunction and Oxidative Damage in Alzheimer's and Parkinson's Diseases and Coenzyme Q10 as a Potential Treatment. J Bioenerg Biomembr. 2004;36(4):381-6. PubMed PMID: 15377876.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mitochondrial dysfunction and oxidative damage in Alzheimer's and Parkinson's diseases and coenzyme Q10 as a potential treatment. A1 - Beal,M Flint, PY - 2004/9/21/pubmed PY - 2005/4/21/medline PY - 2004/9/21/entrez SP - 381 EP - 6 JF - Journal of bioenergetics and biomembranes JO - J Bioenerg Biomembr VL - 36 IS - 4 N2 - There is substantial evidence that mitochondrial dysfunction and oxidative damage may play a key role in the pathogenesis of neurodegenerative disease. Evidence supporting this in both Alzheimer's and Parkinson's diseases is continuing to accumulate. This review discusses the increasing evidence for a role of both mitochondrial dysfunction and oxidative damage in contributing to beta-amyloid deposition in Alzheimer's disease. I also discuss the increasing evidence that Parkinson's disease is associated with abnormalities in the electron transport gene as well as oxidative damage. Lastly, I reviewed the potential efficacy of coenzyme Q as well as a number of other antioxidants in the treatment of both Parkinson's and Alzheimer's diseases. SN - 0145-479X UR - https://www.unboundmedicine.com/medline/citation/15377876/Mitochondrial_dysfunction_and_oxidative_damage_in_Alzheimer's_and_Parkinson's_diseases_and_coenzyme_Q10_as_a_potential_treatment_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=15377876.ui DB - PRIME DP - Unbound Medicine ER -