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Lacrimo-auriculo-dento-digital syndrome. Case report, review of the literature, and clinical spectrum.
J Orofac Orthop. 2004 Sep; 65(5):425-32.JO

Abstract

Lacrimo-auriculo-dento-digital (LADD) syndrome, also known as Levy-Hollister syndrome, is characterized by pronounced dysplasias in various organ systems. The resulting disturbances affect primarily the lacrimal glands, the inner and outer ear, the salivary glands, and the osseous framework. Although the degree to which the different organs are involved varies considerably, dental anomalies are regularly reported. An autosomal-dominant trait has been recognized for this syndrome, but the majority of cases described in the literature concerned sporadic new mutations. We report on this unusual and relatively unknown syndrome with reference to a 13-year-old girl suffering from LADD syndrome presenting symptoms of severe xerostomia and various craniofacial malformations, hearing loss, enamel dysplasia, microdontia, and hypodontia.

Authors+Show Affiliations

Department of Orthodontics, University of Mainz, Germany. m.lehotay@web.deNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng ger

PubMed ID

15378197

Citation

Lehotay, Michaela, et al. "Lacrimo-auriculo-dento-digital Syndrome. Case Report, Review of the Literature, and Clinical Spectrum." Journal of Orofacial Orthopedics = Fortschritte Der Kieferorthopadie : Organ/official Journal Deutsche Gesellschaft Fur Kieferorthopadie, vol. 65, no. 5, 2004, pp. 425-32.
Lehotay M, Kunkel M, Wehrbein H. Lacrimo-auriculo-dento-digital syndrome. Case report, review of the literature, and clinical spectrum. J Orofac Orthop. 2004;65(5):425-32.
Lehotay, M., Kunkel, M., & Wehrbein, H. (2004). Lacrimo-auriculo-dento-digital syndrome. Case report, review of the literature, and clinical spectrum. Journal of Orofacial Orthopedics = Fortschritte Der Kieferorthopadie : Organ/official Journal Deutsche Gesellschaft Fur Kieferorthopadie, 65(5), 425-32.
Lehotay M, Kunkel M, Wehrbein H. Lacrimo-auriculo-dento-digital Syndrome. Case Report, Review of the Literature, and Clinical Spectrum. J Orofac Orthop. 2004;65(5):425-32. PubMed PMID: 15378197.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lacrimo-auriculo-dento-digital syndrome. Case report, review of the literature, and clinical spectrum. AU - Lehotay,Michaela, AU - Kunkel,Martin, AU - Wehrbein,Heinrich, PY - 2003/11/26/received PY - 2004/05/28/accepted PY - 2004/9/21/pubmed PY - 2005/4/1/medline PY - 2004/9/21/entrez SP - 425 EP - 32 JF - Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie JO - J Orofac Orthop VL - 65 IS - 5 N2 - Lacrimo-auriculo-dento-digital (LADD) syndrome, also known as Levy-Hollister syndrome, is characterized by pronounced dysplasias in various organ systems. The resulting disturbances affect primarily the lacrimal glands, the inner and outer ear, the salivary glands, and the osseous framework. Although the degree to which the different organs are involved varies considerably, dental anomalies are regularly reported. An autosomal-dominant trait has been recognized for this syndrome, but the majority of cases described in the literature concerned sporadic new mutations. We report on this unusual and relatively unknown syndrome with reference to a 13-year-old girl suffering from LADD syndrome presenting symptoms of severe xerostomia and various craniofacial malformations, hearing loss, enamel dysplasia, microdontia, and hypodontia. SN - 1434-5293 UR - https://www.unboundmedicine.com/medline/citation/15378197/Lacrimo_auriculo_dento_digital_syndrome__Case_report_review_of_the_literature_and_clinical_spectrum_ L2 - https://dx.doi.org/10.1007/s00056-004-0347-6 DB - PRIME DP - Unbound Medicine ER -