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Ocular manifestations of juvenile rheumatoid arthritis in Olmsted County, Minnesota: a population-based study.
Graefes Arch Clin Exp Ophthalmol. 2005 Mar; 243(3):217-21.GA

Abstract

BACKGROUND

Juvenile rheumatoid arthritis (JRA) is the most common systemic cause of uveitis in Europe and North America. The cumulative incidence of uveitis in JRA has been reported at between 8.5% and 25% in series from referral centers in the USA. There have been no population-based studies of the cumulative incidence of uveitis in JRA in the USA.

METHODS

We performed a population-based, retrospective cohort study of patients residing in Olmsted County, Minnesota between 1 January 1960 and 31 December 2000 who met American College of Rheumatology diagnostic criteria for JRA. The patients were identified using the Rochester Epidemiology Project (REP), a surveillance and medical records-linkage system which provides access to medical records of residents of Olmsted County. Patient histories were reviewed and information regarding rheumatic and ocular disease was extracted and analyzed. The main outcome measures were: cumulative incidence of uveitis, of complications of uveitis, of keratoconjunctivitis sicca (KCS) and of adverse visual outcome.

RESULTS

Of the 88 patients identified, three patients developed uncomplicated uveitis [3.4%; 95% confidence intervals [CI] 0.7-9.6%), all with pauciarticular onset JRA. Two patients developed KCS (2.3%; 95% CI 0.3-8.0%). The visual acuity of these five patients at last follow-up (mean length of follow-up 22.6 years, range 8-36 years) was 20/20. There were no patients with visual loss attributable to JRA.

CONCLUSIONS

In a population-based study of JRA in the United States, uveitis occurred at a lower frequency than expected. In the limited number of cases in this cohort with JRA-associated ophthalmologic complications there was no resulting loss of visual acuity.

Authors+Show Affiliations

Department of Ophthalmology, The George Washington University, Washington, DC, 20037, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15378386

Citation

Carvounis, Petros E., et al. "Ocular Manifestations of Juvenile Rheumatoid Arthritis in Olmsted County, Minnesota: a Population-based Study." Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, vol. 243, no. 3, 2005, pp. 217-21.
Carvounis PE, Herman DC, Cha SS, et al. Ocular manifestations of juvenile rheumatoid arthritis in Olmsted County, Minnesota: a population-based study. Graefes Arch Clin Exp Ophthalmol. 2005;243(3):217-21.
Carvounis, P. E., Herman, D. C., Cha, S. S., & Burke, J. P. (2005). Ocular manifestations of juvenile rheumatoid arthritis in Olmsted County, Minnesota: a population-based study. Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, 243(3), 217-21.
Carvounis PE, et al. Ocular Manifestations of Juvenile Rheumatoid Arthritis in Olmsted County, Minnesota: a Population-based Study. Graefes Arch Clin Exp Ophthalmol. 2005;243(3):217-21. PubMed PMID: 15378386.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ocular manifestations of juvenile rheumatoid arthritis in Olmsted County, Minnesota: a population-based study. AU - Carvounis,Petros E, AU - Herman,David C, AU - Cha,Stephen S, AU - Burke,James P, Y1 - 2004/09/17/ PY - 2004/05/25/received PY - 2004/06/25/accepted PY - 2004/9/21/pubmed PY - 2005/6/21/medline PY - 2004/9/21/entrez SP - 217 EP - 21 JF - Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie JO - Graefes Arch Clin Exp Ophthalmol VL - 243 IS - 3 N2 - BACKGROUND: Juvenile rheumatoid arthritis (JRA) is the most common systemic cause of uveitis in Europe and North America. The cumulative incidence of uveitis in JRA has been reported at between 8.5% and 25% in series from referral centers in the USA. There have been no population-based studies of the cumulative incidence of uveitis in JRA in the USA. METHODS: We performed a population-based, retrospective cohort study of patients residing in Olmsted County, Minnesota between 1 January 1960 and 31 December 2000 who met American College of Rheumatology diagnostic criteria for JRA. The patients were identified using the Rochester Epidemiology Project (REP), a surveillance and medical records-linkage system which provides access to medical records of residents of Olmsted County. Patient histories were reviewed and information regarding rheumatic and ocular disease was extracted and analyzed. The main outcome measures were: cumulative incidence of uveitis, of complications of uveitis, of keratoconjunctivitis sicca (KCS) and of adverse visual outcome. RESULTS: Of the 88 patients identified, three patients developed uncomplicated uveitis [3.4%; 95% confidence intervals [CI] 0.7-9.6%), all with pauciarticular onset JRA. Two patients developed KCS (2.3%; 95% CI 0.3-8.0%). The visual acuity of these five patients at last follow-up (mean length of follow-up 22.6 years, range 8-36 years) was 20/20. There were no patients with visual loss attributable to JRA. CONCLUSIONS: In a population-based study of JRA in the United States, uveitis occurred at a lower frequency than expected. In the limited number of cases in this cohort with JRA-associated ophthalmologic complications there was no resulting loss of visual acuity. SN - 0721-832X UR - https://www.unboundmedicine.com/medline/citation/15378386/Ocular_manifestations_of_juvenile_rheumatoid_arthritis_in_Olmsted_County_Minnesota:_a_population_based_study_ L2 - https://dx.doi.org/10.1007/s00417-004-0988-6 DB - PRIME DP - Unbound Medicine ER -