Tags

Type your tag names separated by a space and hit enter

Folic acid: neurochemistry, metabolism and relationship to depression.

Abstract

The associations of folic acid and its derivatives with depressive disorder are reviewed. Derivatives of folic acid such as biopterins and the synthesis of S-adenosyl methionine (SAM) are known either to be associated with improvement or to have a direct therapeutic effect in depressive disorder. Studies investigating plasma and red cell folic acid levels in depressed patients have used differing assay methodologies which make comparison difficult, although there is substantial evidence of the association between depressive disorder (particularly severe depression) and low folic acid levels. The few studies available suggest folic acid has either antidepressant properties or can act as an augmenting agent for standard antidepressant treatment. A recently discovered genetic variant (5,10 MTHFR) leading to altered folic acid metabolism may explain why some individuals are vulnerable to the effects of folic acid deficiency, despite adequate intake. The links of 5,10 MTHFR to the presence of depressive disorder in the community are being investigated.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Mental Health, Queen's University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland.

    ,

    Source

    Human psychopharmacology 19:7 2004 Oct pg 477-88

    MeSH

    Brain
    Depressive Disorder
    Dietary Supplements
    Folic Acid
    Homocysteine
    Humans

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    15378677

    Citation

    Paul, Raymond T P., et al. "Folic Acid: Neurochemistry, Metabolism and Relationship to Depression." Human Psychopharmacology, vol. 19, no. 7, 2004, pp. 477-88.
    Paul RT, McDonnell AP, Kelly CB. Folic acid: neurochemistry, metabolism and relationship to depression. Hum Psychopharmacol. 2004;19(7):477-88.
    Paul, R. T., McDonnell, A. P., & Kelly, C. B. (2004). Folic acid: neurochemistry, metabolism and relationship to depression. Human Psychopharmacology, 19(7), pp. 477-88.
    Paul RT, McDonnell AP, Kelly CB. Folic Acid: Neurochemistry, Metabolism and Relationship to Depression. Hum Psychopharmacol. 2004;19(7):477-88. PubMed PMID: 15378677.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Folic acid: neurochemistry, metabolism and relationship to depression. AU - Paul,Raymond T P, AU - McDonnell,Anne P, AU - Kelly,Christopher B, PY - 2004/9/21/pubmed PY - 2005/1/13/medline PY - 2004/9/21/entrez SP - 477 EP - 88 JF - Human psychopharmacology JO - Hum Psychopharmacol VL - 19 IS - 7 N2 - The associations of folic acid and its derivatives with depressive disorder are reviewed. Derivatives of folic acid such as biopterins and the synthesis of S-adenosyl methionine (SAM) are known either to be associated with improvement or to have a direct therapeutic effect in depressive disorder. Studies investigating plasma and red cell folic acid levels in depressed patients have used differing assay methodologies which make comparison difficult, although there is substantial evidence of the association between depressive disorder (particularly severe depression) and low folic acid levels. The few studies available suggest folic acid has either antidepressant properties or can act as an augmenting agent for standard antidepressant treatment. A recently discovered genetic variant (5,10 MTHFR) leading to altered folic acid metabolism may explain why some individuals are vulnerable to the effects of folic acid deficiency, despite adequate intake. The links of 5,10 MTHFR to the presence of depressive disorder in the community are being investigated. SN - 0885-6222 UR - https://www.unboundmedicine.com/medline/citation/15378677/full_citation L2 - https://doi.org/10.1002/hup.614 DB - PRIME DP - Unbound Medicine ER -