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[Xanthones from Tibetan medicine Halenia elliptica and their antioxidant activity].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2004 Aug; 26(4):364-7.ZY

Abstract

OBJECTIVE

To investigate the xanthones from Tibetan medicine Halenia elliptica and their antioxidant activity.

METHODS

Column chromatography over normal phase silica gel, reversed phase silica gel, Sephadex LH-20, and recrystallization techniques were used to isolate and purify constituents from Halenia elliptica. Infrared spectrometry, mass spectrometry, and nuclear magnetic resonance spectrometry were used to identify the structure of compounds. The antioxidant activity was evaluated by measuring the content of malondialdehyde product in mice liver cell microsomal induced by ferrous-cysteine.

RESULTS

Eight xanthones (compound I-VIII) were isolated and identified from the ethyl acetate extract of Halenia elliptica, among which 1,7-dihydroxy-2,3,5-trimethoxyxanthone was a novel compound. Compound I, III at 10 microg/ml and 100 microg/ml could inhibit the production of malondialdehyde in mouse liver microsomes in vitro.

CONCLUSION

Eight xanthones were isolated and they have certain antioxidant activity.

Authors+Show Affiliations

Gao J
Department of Chemistry of Natural Products, Institute of Materia Medica, CAMS and PUMC, Beijing 100050, China.
Wang SJ
No affiliation info available
Fang F
No affiliation info available
Si YK
No affiliation info available
Yang YC
No affiliation info available
Liu GT
No affiliation info available
Jian-gong S
No affiliation info available

MeSH

AntioxidantsDrugs, Chinese HerbalGentianaceaeGlycosidesPlants, MedicinalXanthenesXanthones

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

15379257

Citation

Gao, Jie, et al. "[Xanthones From Tibetan Medicine Halenia Elliptica and Their Antioxidant Activity]." Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae, vol. 26, no. 4, 2004, pp. 364-7.
Gao J, Wang SJ, Fang F, et al. [Xanthones from Tibetan medicine Halenia elliptica and their antioxidant activity]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2004;26(4):364-7.
Gao, J., Wang, S. J., Fang, F., Si, Y. K., Yang, Y. C., Liu, G. T., & Jian-gong, S. (2004). [Xanthones from Tibetan medicine Halenia elliptica and their antioxidant activity]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae, 26(4), 364-7.
Gao J, et al. [Xanthones From Tibetan Medicine Halenia Elliptica and Their Antioxidant Activity]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2004;26(4):364-7. PubMed PMID: 15379257.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Xanthones from Tibetan medicine Halenia elliptica and their antioxidant activity]. AU - Gao,Jie, AU - Wang,Su-juan, AU - Fang,Fang, AU - Si,Yi-kang, AU - Yang,Yong-chun, AU - Liu,Geng-tao, AU - Jian-gong,Shi, PY - 2004/9/24/pubmed PY - 2005/2/16/medline PY - 2004/9/24/entrez SP - 364 EP - 7 JF - Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae JO - Zhongguo Yi Xue Ke Xue Yuan Xue Bao VL - 26 IS - 4 N2 - OBJECTIVE: To investigate the xanthones from Tibetan medicine Halenia elliptica and their antioxidant activity. METHODS: Column chromatography over normal phase silica gel, reversed phase silica gel, Sephadex LH-20, and recrystallization techniques were used to isolate and purify constituents from Halenia elliptica. Infrared spectrometry, mass spectrometry, and nuclear magnetic resonance spectrometry were used to identify the structure of compounds. The antioxidant activity was evaluated by measuring the content of malondialdehyde product in mice liver cell microsomal induced by ferrous-cysteine. RESULTS: Eight xanthones (compound I-VIII) were isolated and identified from the ethyl acetate extract of Halenia elliptica, among which 1,7-dihydroxy-2,3,5-trimethoxyxanthone was a novel compound. Compound I, III at 10 microg/ml and 100 microg/ml could inhibit the production of malondialdehyde in mouse liver microsomes in vitro. CONCLUSION: Eight xanthones were isolated and they have certain antioxidant activity. SN - 1000-503X UR - https://www.unboundmedicine.com/medline/citation/15379257/[Xanthones_from_Tibetan_medicine_Halenia_elliptica_and_their_antioxidant_activity]_ DB - PRIME DP - Unbound Medicine ER -