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[Effectiveness of flutamide alone or combined with oral contraceptives in the treatment of hirsutism in women].
Rev Med Chil. 2004 Jul; 132(7):845-52.RM

Abstract

BACKGROUND

Flutamide is an antiandrogen devoid of other hormonal effects, except for a decrease in the secretion of adrenal androgens such as dehydroepidandrosterone sulphate (DHEA-s) and androstenedione.

AIM

To assess the effectiveness of flutamide in the treatment of hirsutism, used as monotherapy or combined with oral contraceptives (OC).

PATIENTS AND METHODS

Women with peripheral hirsutism (defined as the presence of normal serum androgen levels and normal ovulatory menstrual cycles) were assigned to receive flutamide alone (500 mg/day) or flutamide plus an OC (ethynylestradiol 0.03 mg and desogestrel 150 microg). Hirsute with hyperandrogenism (polycystic ovary syndrome) were assigned to receive flutamide plus an OC. The degree of hirsutism was assessed using a clinical score (Moncada) at three, six and twelve months of therapy.

RESULTS

Twenty five women with peripheral hirsutism received flutamide alone and 18 receive flutamide plus the contraceptive. Eighteen women with polycystic ovary syndrome were studied. At three months, the reduction in hirsutism was 11.2, 15.9 and 24.7% in women with peripheral hirsutism receiving flutamide alone or flutamide plus OC and in hyperandrogenic women receiving flutamide plus OC, respectively. At twelve months, the figures were 57.2, 57.3 and 52.5% respectively. In hyperandrogenic women, at baseline and three months, serum testosterone levels were 0.96 and 0.42 ng/nl and serum DHEA-s levels were 2,980 and 1,490 ng/ml respectively. No collateral effects of treatment or elevations in serum transaminase levels were observed.

CONCLUSIONS

Flutamide is effective in the treatment of hirsutism in women with normal or elevated androgen levels. Adding OC did not improve the efficacy of the drug.

Authors+Show Affiliations

Devoto E
Facultad de Medicina de la Universidad de Chile, Campus Central, Servicio de Medicina, Sección Endocrinología, Hospital Clínico San Borja-Arriarán, Santiago de Chile. edevoto@vtr.net
Aravena L
No affiliation info available

MeSH

AdolescentAdultAndrogen AntagonistsAndrogensBiomarkersCohort StudiesContraceptives, Oral, CombinedFemaleFlutamideHirsutismHumansPolycystic Ovary SyndromeTreatment Outcome

Pub Type(s)

Clinical Trial
English Abstract
Journal Article

Language

spa

PubMed ID

15379332

Citation

Devoto, Enzo, and Lucía Aravena. "[Effectiveness of Flutamide Alone or Combined With Oral Contraceptives in the Treatment of Hirsutism in Women]." Revista Medica De Chile, vol. 132, no. 7, 2004, pp. 845-52.
Devoto E, Aravena L. [Effectiveness of flutamide alone or combined with oral contraceptives in the treatment of hirsutism in women]. Rev Med Chil. 2004;132(7):845-52.
Devoto, E., & Aravena, L. (2004). [Effectiveness of flutamide alone or combined with oral contraceptives in the treatment of hirsutism in women]. Revista Medica De Chile, 132(7), 845-52.
Devoto E, Aravena L. [Effectiveness of Flutamide Alone or Combined With Oral Contraceptives in the Treatment of Hirsutism in Women]. Rev Med Chil. 2004;132(7):845-52. PubMed PMID: 15379332.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effectiveness of flutamide alone or combined with oral contraceptives in the treatment of hirsutism in women]. AU - Devoto,Enzo, AU - Aravena,Lucía, PY - 2004/9/24/pubmed PY - 2005/5/25/medline PY - 2004/9/24/entrez SP - 845 EP - 52 JF - Revista medica de Chile JO - Rev Med Chil VL - 132 IS - 7 N2 - BACKGROUND: Flutamide is an antiandrogen devoid of other hormonal effects, except for a decrease in the secretion of adrenal androgens such as dehydroepidandrosterone sulphate (DHEA-s) and androstenedione. AIM: To assess the effectiveness of flutamide in the treatment of hirsutism, used as monotherapy or combined with oral contraceptives (OC). PATIENTS AND METHODS: Women with peripheral hirsutism (defined as the presence of normal serum androgen levels and normal ovulatory menstrual cycles) were assigned to receive flutamide alone (500 mg/day) or flutamide plus an OC (ethynylestradiol 0.03 mg and desogestrel 150 microg). Hirsute with hyperandrogenism (polycystic ovary syndrome) were assigned to receive flutamide plus an OC. The degree of hirsutism was assessed using a clinical score (Moncada) at three, six and twelve months of therapy. RESULTS: Twenty five women with peripheral hirsutism received flutamide alone and 18 receive flutamide plus the contraceptive. Eighteen women with polycystic ovary syndrome were studied. At three months, the reduction in hirsutism was 11.2, 15.9 and 24.7% in women with peripheral hirsutism receiving flutamide alone or flutamide plus OC and in hyperandrogenic women receiving flutamide plus OC, respectively. At twelve months, the figures were 57.2, 57.3 and 52.5% respectively. In hyperandrogenic women, at baseline and three months, serum testosterone levels were 0.96 and 0.42 ng/nl and serum DHEA-s levels were 2,980 and 1,490 ng/ml respectively. No collateral effects of treatment or elevations in serum transaminase levels were observed. CONCLUSIONS: Flutamide is effective in the treatment of hirsutism in women with normal or elevated androgen levels. Adding OC did not improve the efficacy of the drug. SN - 0034-9887 UR - https://www.unboundmedicine.com/medline/citation/15379332/[Effectiveness_of_flutamide_alone_or_combined_with_oral_contraceptives_in_the_treatment_of_hirsutism_in_women]_ DB - PRIME DP - Unbound Medicine ER -