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Onset and disappearance of reflux symptoms in a Chinese population: a 1-year follow-up study.
Aliment Pharmacol Ther 2004; 20(7):803-12AP

Abstract

BACKGROUND

The natural history of gastro-oesophageal reflux disease in Asian population has not been studied before.

AIM

To study the onset and disappearances of reflux symptoms over a 1-year period in the Chinese population.

METHODS

A population-based telephone survey was performed in 2002 and repeated 1 year later. The change in prevalence rate, onset and disappearance of gastro-oesophageal reflux disease, and the change in diagnoses were assessed. Factors associated with the onset and disappearance of gastro-oesophageal reflux disease were studied.

RESULTS

A total of 712 subjects completed the first and second survey. The annual, monthly and weekly prevalence of gastro-oesophageal reflux disease were 34.1%, 10.1% and 2.7% respectively. The onset rate (per 1000 person-year) and disappearance rate of any gastro-oesophageal reflux disease and frequent gastro-oesophageal reflux disease (> or = monthly symptoms) were 209, 40; and 395, 243 respectively. Forty-four percentage of gastro-oesophageal reflux disease subjects changed their diagnoses in 2003. By multiple logistic regression analysis, high anxiety score (OR: 1.2, 95% CI: 1.1-1.2) and higher educational level (OR: 2.7, 95% CI: 1.3-6.3) were associated with the onset of gastro-oesophageal reflux disease; while the frequency of acid regurgitation (OR: 0.35, 95% CI: 0.17-0.70) and use of antisecretory therapy (OR: 0.50, 95% CI: 0.28-0.89) were associated with the disappearance of gastro-oesophageal reflux disease.

CONCLUSION

The prevalence of gastro-oesophageal reflux disease is stable over 1 year. Higher anxiety score and higher educational level were associated with the onset of gastro-oesophageal reflux disease, while lower frequency of reflux symptoms and infrequent use of antisecretory therapy were associated with the disappearance of gastro-oesophageal reflux disease in a Chinese population.

Authors+Show Affiliations

Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15379841

Citation

Wong, W M., et al. "Onset and Disappearance of Reflux Symptoms in a Chinese Population: a 1-year Follow-up Study." Alimentary Pharmacology & Therapeutics, vol. 20, no. 7, 2004, pp. 803-12.
Wong WM, Lai KC, Lam KF, et al. Onset and disappearance of reflux symptoms in a Chinese population: a 1-year follow-up study. Aliment Pharmacol Ther. 2004;20(7):803-12.
Wong, W. M., Lai, K. C., Lam, K. F., Hui, W. M., Huang, J. Q., Xia, H. H., ... Wong, B. C. (2004). Onset and disappearance of reflux symptoms in a Chinese population: a 1-year follow-up study. Alimentary Pharmacology & Therapeutics, 20(7), pp. 803-12.
Wong WM, et al. Onset and Disappearance of Reflux Symptoms in a Chinese Population: a 1-year Follow-up Study. Aliment Pharmacol Ther. 2004 Oct 1;20(7):803-12. PubMed PMID: 15379841.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Onset and disappearance of reflux symptoms in a Chinese population: a 1-year follow-up study. AU - Wong,W M, AU - Lai,K C, AU - Lam,K F, AU - Hui,W M, AU - Huang,J Q, AU - Xia,H H X, AU - Hu,W H C, AU - Lam,C L K, AU - Chan,C K, AU - Lam,S K, AU - Wong,B C Y, PY - 2004/9/24/pubmed PY - 2004/12/18/medline PY - 2004/9/24/entrez SP - 803 EP - 12 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 20 IS - 7 N2 - BACKGROUND: The natural history of gastro-oesophageal reflux disease in Asian population has not been studied before. AIM: To study the onset and disappearances of reflux symptoms over a 1-year period in the Chinese population. METHODS: A population-based telephone survey was performed in 2002 and repeated 1 year later. The change in prevalence rate, onset and disappearance of gastro-oesophageal reflux disease, and the change in diagnoses were assessed. Factors associated with the onset and disappearance of gastro-oesophageal reflux disease were studied. RESULTS: A total of 712 subjects completed the first and second survey. The annual, monthly and weekly prevalence of gastro-oesophageal reflux disease were 34.1%, 10.1% and 2.7% respectively. The onset rate (per 1000 person-year) and disappearance rate of any gastro-oesophageal reflux disease and frequent gastro-oesophageal reflux disease (> or = monthly symptoms) were 209, 40; and 395, 243 respectively. Forty-four percentage of gastro-oesophageal reflux disease subjects changed their diagnoses in 2003. By multiple logistic regression analysis, high anxiety score (OR: 1.2, 95% CI: 1.1-1.2) and higher educational level (OR: 2.7, 95% CI: 1.3-6.3) were associated with the onset of gastro-oesophageal reflux disease; while the frequency of acid regurgitation (OR: 0.35, 95% CI: 0.17-0.70) and use of antisecretory therapy (OR: 0.50, 95% CI: 0.28-0.89) were associated with the disappearance of gastro-oesophageal reflux disease. CONCLUSION: The prevalence of gastro-oesophageal reflux disease is stable over 1 year. Higher anxiety score and higher educational level were associated with the onset of gastro-oesophageal reflux disease, while lower frequency of reflux symptoms and infrequent use of antisecretory therapy were associated with the disappearance of gastro-oesophageal reflux disease in a Chinese population. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/15379841/Onset_and_disappearance_of_reflux_symptoms_in_a_Chinese_population:_a_1_year_follow_up_study_ L2 - https://doi.org/10.1111/j.1365-2036.2004.02198.x DB - PRIME DP - Unbound Medicine ER -