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Prevention of ultraviolet-induced skin pigmentation.
Photodermatol Photoimmunol Photomed. 2004 Oct; 20(5):243-7.PP

Abstract

BACKGROUND/PURPOSE

Exposure to ultraviolet (UV) radiation increases skin pigmentation and usually results in an even darkening of the skin. However, it may also occasionally lead to the development of hyperpigmented lesions due to a local overproduction of pigment. Skin pigmentation is induced both by UVB and UVA rays.

METHODS

The in vivo protection by sunscreens against pigmentation was studied using the determination of a level of protection against pigmentation based on the standardized sun protection factor (SPF) test method. The method includes delayed UVB and UVA pigmentations. The level of prevention against pigmentation was determined 7 days after exposure to solar-simulated radiation by visual assessment. It was calculated using the ratio of the minimal pigmenting dose on protected skin to the minimal pigmenting dose on unprotected skin. Broadspectrum UVB/UVA filters, Mexoryl SX and Mexoryl XL, and complete formula were tested.

RESULTS

Protection against pigmentation correlates with the concentration of Mexoryl SX. The levels of protection obtained show a synergetic effect of Mexoryl SX when associated with Mexoryl XL. When different products having the same SPF (same protection against erythema) and different levels of UVA protection are compared, only sunscreen products with a high level of UVA protection show a similar level of protection against sunburn and pigmentation. Products with low UVA protection have a lower capacity of preventing induced pigmentation compared with their efficacy against erythema.

CONCLUSIONS

These studies have evidenced that SPF determination was not sufficient to account for the efficiency in preventing pigmentation and that UVA protection was an essential part of this prevention.

Authors+Show Affiliations

L'Oréal Recherche, 8/12 Impasse Barbier, 92117 Clichy, France. dmoyal@rd.loreal.com

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15379874

Citation

Moyal, Dominique. "Prevention of Ultraviolet-induced Skin Pigmentation." Photodermatology, Photoimmunology & Photomedicine, vol. 20, no. 5, 2004, pp. 243-7.
Moyal D. Prevention of ultraviolet-induced skin pigmentation. Photodermatol Photoimmunol Photomed. 2004;20(5):243-7.
Moyal, D. (2004). Prevention of ultraviolet-induced skin pigmentation. Photodermatology, Photoimmunology & Photomedicine, 20(5), 243-7.
Moyal D. Prevention of Ultraviolet-induced Skin Pigmentation. Photodermatol Photoimmunol Photomed. 2004;20(5):243-7. PubMed PMID: 15379874.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention of ultraviolet-induced skin pigmentation. A1 - Moyal,Dominique, PY - 2004/9/24/pubmed PY - 2005/2/3/medline PY - 2004/9/24/entrez SP - 243 EP - 7 JF - Photodermatology, photoimmunology & photomedicine JO - Photodermatol Photoimmunol Photomed VL - 20 IS - 5 N2 - BACKGROUND/PURPOSE: Exposure to ultraviolet (UV) radiation increases skin pigmentation and usually results in an even darkening of the skin. However, it may also occasionally lead to the development of hyperpigmented lesions due to a local overproduction of pigment. Skin pigmentation is induced both by UVB and UVA rays. METHODS: The in vivo protection by sunscreens against pigmentation was studied using the determination of a level of protection against pigmentation based on the standardized sun protection factor (SPF) test method. The method includes delayed UVB and UVA pigmentations. The level of prevention against pigmentation was determined 7 days after exposure to solar-simulated radiation by visual assessment. It was calculated using the ratio of the minimal pigmenting dose on protected skin to the minimal pigmenting dose on unprotected skin. Broadspectrum UVB/UVA filters, Mexoryl SX and Mexoryl XL, and complete formula were tested. RESULTS: Protection against pigmentation correlates with the concentration of Mexoryl SX. The levels of protection obtained show a synergetic effect of Mexoryl SX when associated with Mexoryl XL. When different products having the same SPF (same protection against erythema) and different levels of UVA protection are compared, only sunscreen products with a high level of UVA protection show a similar level of protection against sunburn and pigmentation. Products with low UVA protection have a lower capacity of preventing induced pigmentation compared with their efficacy against erythema. CONCLUSIONS: These studies have evidenced that SPF determination was not sufficient to account for the efficiency in preventing pigmentation and that UVA protection was an essential part of this prevention. SN - 0905-4383 UR - https://www.unboundmedicine.com/medline/citation/15379874/Prevention_of_ultraviolet_induced_skin_pigmentation_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0905-4383&date=2004&volume=20&issue=5&spage=243 DB - PRIME DP - Unbound Medicine ER -