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Dietary factors and Alzheimer's disease.
Lancet Neurol. 2004 Oct; 3(10):579-87.LN

Abstract

Alzheimer's disease (AD) is increasing in prevalence, and environmental risk factors have not been identified with certainty. There is evidence that oxidative stress, homocysteine-related vitamins, fats, and alcohol have a role in the pathogenesis of AD. Few large epidemiological studies have explored the associations between nutrients and AD, and there has been only one trial of vitamin E in the prevention of AD. Some studies suggest that high intake of vitamins C, E, B6, and B12, and folate, unsaturated fatty acids, and fish are related to a low risk of AD, but reports are inconsistent. Modest to moderate alcohol intake, particularly wine, may be related to a low risk of AD. Available data do not permit definitive conclusions regarding diet and AD or specific recommendations on diet modification for the prevention of AD.

Authors+Show Affiliations

Luchsinger JA
Taub Institute for Research of Alzheimer's Disease and the Aging Brain, Division of General Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, USA.
Mayeux R
No affiliation info available

MeSH

Alzheimer DiseaseAnimalsDietHumansNutritional RequirementsRisk Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

15380154

Citation

Luchsinger, José A., and Richard Mayeux. "Dietary Factors and Alzheimer's Disease." The Lancet. Neurology, vol. 3, no. 10, 2004, pp. 579-87.
Luchsinger JA, Mayeux R. Dietary factors and Alzheimer's disease. Lancet Neurol. 2004;3(10):579-87.
Luchsinger, J. A., & Mayeux, R. (2004). Dietary factors and Alzheimer's disease. The Lancet. Neurology, 3(10), 579-87.
Luchsinger JA, Mayeux R. Dietary Factors and Alzheimer's Disease. Lancet Neurol. 2004;3(10):579-87. PubMed PMID: 15380154.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary factors and Alzheimer's disease. AU - Luchsinger,José A, AU - Mayeux,Richard, PY - 2004/9/24/pubmed PY - 2004/10/16/medline PY - 2004/9/24/entrez SP - 579 EP - 87 JF - The Lancet. Neurology JO - Lancet Neurol VL - 3 IS - 10 N2 - Alzheimer's disease (AD) is increasing in prevalence, and environmental risk factors have not been identified with certainty. There is evidence that oxidative stress, homocysteine-related vitamins, fats, and alcohol have a role in the pathogenesis of AD. Few large epidemiological studies have explored the associations between nutrients and AD, and there has been only one trial of vitamin E in the prevention of AD. Some studies suggest that high intake of vitamins C, E, B6, and B12, and folate, unsaturated fatty acids, and fish are related to a low risk of AD, but reports are inconsistent. Modest to moderate alcohol intake, particularly wine, may be related to a low risk of AD. Available data do not permit definitive conclusions regarding diet and AD or specific recommendations on diet modification for the prevention of AD. SN - 1474-4422 UR - https://www.unboundmedicine.com/medline/citation/15380154/full_citation DB - PRIME DP - Unbound Medicine ER -