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Wine, beer and spirits and risk of oral and pharyngeal cancer: a case-control study from Italy and Switzerland.
Oral Oncol. 2004 Oct; 40(9):904-9.OO

Abstract

We examined the relation between consumption of different types of alcoholic beverages and the risk of oral and pharyngeal cancer, using data from a case-control study conducted in Italy and Switzerland between 1992 and 1997. This included a total of 749 cases of oral and pharyngeal cancer and 1,772 hospital controls, admitted for acute, non-neoplastic conditions, unrelated to alcohol and smoking consumption. Significant trends in risk were found with increasing total alcohol intake, with multivariate odds ratios (OR) of 2.1 for drinkers of 3-4 drinks/day, as compared to abstainers or light drinkers (< or = 2 drinks/day), 5.0 for 5-7, 12.2 for 8-11 and 21.1 for > or = 12 drinks/day. Similar increased risks for subsequent levels of consumption were found for wine drinkers. After allowance for wine intake, the ORs for beer drinkers were 1.2 for 1-2 drinks/day, and 2.3 for > or = 3 drinks/day. Corresponding values for spirit drinkers were 1.0 and 1.9. Patterns of risk for wine drinkers were similar for wine only drinkers and drinkers of wine, plus beer and spirits. Our study indicates that in populations with frequent wine consumption, wine per se can strongly increase the risk of cancer of the oral cavity and pharynx, and confirms that the most prevalent alcoholic beverage in each population tends to be the one with the highest risk.

Authors+Show Affiliations

Istituto di Ricerche Farmacologiche Mario Negri, via Eritrea 62, 20157 Milano, Italy. altieri@marionegri.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15380168

Citation

Altieri, Andrea, et al. "Wine, Beer and Spirits and Risk of Oral and Pharyngeal Cancer: a Case-control Study From Italy and Switzerland." Oral Oncology, vol. 40, no. 9, 2004, pp. 904-9.
Altieri A, Bosetti C, Gallus S, et al. Wine, beer and spirits and risk of oral and pharyngeal cancer: a case-control study from Italy and Switzerland. Oral Oncol. 2004;40(9):904-9.
Altieri, A., Bosetti, C., Gallus, S., Franceschi, S., Dal Maso, L., Talamini, R., Levi, F., Negri, E., Rodriguez, T., & La Vecchia, C. (2004). Wine, beer and spirits and risk of oral and pharyngeal cancer: a case-control study from Italy and Switzerland. Oral Oncology, 40(9), 904-9.
Altieri A, et al. Wine, Beer and Spirits and Risk of Oral and Pharyngeal Cancer: a Case-control Study From Italy and Switzerland. Oral Oncol. 2004;40(9):904-9. PubMed PMID: 15380168.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Wine, beer and spirits and risk of oral and pharyngeal cancer: a case-control study from Italy and Switzerland. AU - Altieri,Andrea, AU - Bosetti,Cristina, AU - Gallus,Silvano, AU - Franceschi,Silvia, AU - Dal Maso,Luigino, AU - Talamini,Renato, AU - Levi,Fabio, AU - Negri,Eva, AU - Rodriguez,Teresa, AU - La Vecchia,Carlo, PY - 2004/03/30/received PY - 2004/04/19/accepted PY - 2004/9/24/pubmed PY - 2005/2/4/medline PY - 2004/9/24/entrez SP - 904 EP - 9 JF - Oral oncology JO - Oral Oncol. VL - 40 IS - 9 N2 - We examined the relation between consumption of different types of alcoholic beverages and the risk of oral and pharyngeal cancer, using data from a case-control study conducted in Italy and Switzerland between 1992 and 1997. This included a total of 749 cases of oral and pharyngeal cancer and 1,772 hospital controls, admitted for acute, non-neoplastic conditions, unrelated to alcohol and smoking consumption. Significant trends in risk were found with increasing total alcohol intake, with multivariate odds ratios (OR) of 2.1 for drinkers of 3-4 drinks/day, as compared to abstainers or light drinkers (< or = 2 drinks/day), 5.0 for 5-7, 12.2 for 8-11 and 21.1 for > or = 12 drinks/day. Similar increased risks for subsequent levels of consumption were found for wine drinkers. After allowance for wine intake, the ORs for beer drinkers were 1.2 for 1-2 drinks/day, and 2.3 for > or = 3 drinks/day. Corresponding values for spirit drinkers were 1.0 and 1.9. Patterns of risk for wine drinkers were similar for wine only drinkers and drinkers of wine, plus beer and spirits. Our study indicates that in populations with frequent wine consumption, wine per se can strongly increase the risk of cancer of the oral cavity and pharynx, and confirms that the most prevalent alcoholic beverage in each population tends to be the one with the highest risk. SN - 1368-8375 UR - https://www.unboundmedicine.com/medline/citation/15380168/Wine_beer_and_spirits_and_risk_of_oral_and_pharyngeal_cancer:_a_case_control_study_from_Italy_and_Switzerland_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S136883750400096X DB - PRIME DP - Unbound Medicine ER -