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Free radicals in cell biology.
Int Rev Cytol 2004; 237:57-89IR

Abstract

In aerobic cells, free radicals are constantly produced mostly as reactive oxygen species. Once produced, free radicals are removed by antioxidant defenses including enzyme catalase, glutathione peroxidase, and superoxide dismutase. Reactive oxygen species, including nitric oxide and related species, commonly exert a series of useful physiological effects. However, imbalance between prooxidant and antioxidant defenses in favor of prooxidants results in oxidative stress associated with the oxidative modification of biomolecules such as lipids, proteins, and nucleic acids. Alone or in combination with primary ethiological factors, free radicals are involved in a pathogenesis of more than a hundred diseases. This chapter reviews the basic science of some of the potential sources and characteristics of free radicals, as well as antioxidant enzymes. Special attention is paid to the role of free radicals in the pathogenesis of atherosclerosis and immunology-mediated inflammatory reaction.

Authors+Show Affiliations

Institute for Biochemistry, Faculty of Medicine, University of Nis, Serbia and Montenegro USA.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

15380666

Citation

Djordjević, Vidosava B.. "Free Radicals in Cell Biology." International Review of Cytology, vol. 237, 2004, pp. 57-89.
Djordjević VB. Free radicals in cell biology. Int Rev Cytol. 2004;237:57-89.
Djordjević, V. B. (2004). Free radicals in cell biology. International Review of Cytology, 237, pp. 57-89.
Djordjević VB. Free Radicals in Cell Biology. Int Rev Cytol. 2004;237:57-89. PubMed PMID: 15380666.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Free radicals in cell biology. A1 - Djordjević,Vidosava B, PY - 2004/9/24/pubmed PY - 2004/11/2/medline PY - 2004/9/24/entrez SP - 57 EP - 89 JF - International review of cytology JO - Int. Rev. Cytol. VL - 237 N2 - In aerobic cells, free radicals are constantly produced mostly as reactive oxygen species. Once produced, free radicals are removed by antioxidant defenses including enzyme catalase, glutathione peroxidase, and superoxide dismutase. Reactive oxygen species, including nitric oxide and related species, commonly exert a series of useful physiological effects. However, imbalance between prooxidant and antioxidant defenses in favor of prooxidants results in oxidative stress associated with the oxidative modification of biomolecules such as lipids, proteins, and nucleic acids. Alone or in combination with primary ethiological factors, free radicals are involved in a pathogenesis of more than a hundred diseases. This chapter reviews the basic science of some of the potential sources and characteristics of free radicals, as well as antioxidant enzymes. Special attention is paid to the role of free radicals in the pathogenesis of atherosclerosis and immunology-mediated inflammatory reaction. SN - 0074-7696 UR - https://www.unboundmedicine.com/medline/citation/15380666/Free_radicals_in_cell_biology_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0074769604370026 DB - PRIME DP - Unbound Medicine ER -