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Nutritional support in patients with chronic obstructive pulmonary disease during hospitalization for an acute exacerbation; a randomized controlled feasibility trial.
Clin Nutr 2004; 23(5):1184-92CN

Abstract

BACKGROUND & AIMS

Previous studies reported a severely impaired energy balance in COPD patients during the first days of an acute exacerbation, mainly due to a decreased energy and protein intake. The aim of the study was to investigate the feasibility and effectiveness of energy- and protein-rich nutritional supplements during hospitalization for an acute exacerbation in nutritionally depleted COPD patients.

METHODS

In a randomized double-blind, placebo-controlled two-center trial, 56 COPD patients were randomized and 47 patients completed the study. Nutritional intervention consisted of 3 x 125 ml (2.38 MJ/day) and the placebo group received similar amounts of a non-caloric fluid. Medical therapy and dietetic consultation were standardized and dietary intake was measured daily. Body composition, respiratory and skeletal muscle strength, lung function and symptoms were measured on admission and on days 4 and 8 of hospitalization.

RESULTS

Forty-seven percent of the patients had experienced recent involuntary weight loss prior to admission. The degree of weight loss was inversely related to resting arterial oxygen tension (r = 0.31; P < 0.05). Nutritional intervention resulted in a significant increase in energy (16% vs. placebo) and protein intake (38% vs. placebo). Mean duration of hospitalization was 9 +/- 2 days. Relative to usual care, no additional improvements in lung function or muscle strength were seen after nutritional intervention.

CONCLUSIONS

Oral nutritional supplementation during hospitalization for an acute exacerbation is feasible in nutritionally depleted COPD patients and does not interfere with normal dietary intake.

Authors+Show Affiliations

Department of Respiratory Medicine, University Hospital Maastricht, The Netherlands. vermeeren.marja@zonnet.nlNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

15380912

Citation

Vermeeren, M A P., et al. "Nutritional Support in Patients With Chronic Obstructive Pulmonary Disease During Hospitalization for an Acute Exacerbation; a Randomized Controlled Feasibility Trial." Clinical Nutrition (Edinburgh, Scotland), vol. 23, no. 5, 2004, pp. 1184-92.
Vermeeren MA, Wouters EF, Geraerts-Keeris AJ, et al. Nutritional support in patients with chronic obstructive pulmonary disease during hospitalization for an acute exacerbation; a randomized controlled feasibility trial. Clin Nutr. 2004;23(5):1184-92.
Vermeeren, M. A., Wouters, E. F., Geraerts-Keeris, A. J., & Schols, A. M. (2004). Nutritional support in patients with chronic obstructive pulmonary disease during hospitalization for an acute exacerbation; a randomized controlled feasibility trial. Clinical Nutrition (Edinburgh, Scotland), 23(5), pp. 1184-92.
Vermeeren MA, et al. Nutritional Support in Patients With Chronic Obstructive Pulmonary Disease During Hospitalization for an Acute Exacerbation; a Randomized Controlled Feasibility Trial. Clin Nutr. 2004;23(5):1184-92. PubMed PMID: 15380912.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nutritional support in patients with chronic obstructive pulmonary disease during hospitalization for an acute exacerbation; a randomized controlled feasibility trial. AU - Vermeeren,M A P, AU - Wouters,E F M, AU - Geraerts-Keeris,A J W, AU - Schols,A M W J, PY - 2003/09/18/received PY - 2004/03/19/accepted PY - 2004/9/24/pubmed PY - 2005/4/9/medline PY - 2004/9/24/entrez SP - 1184 EP - 92 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 23 IS - 5 N2 - BACKGROUND & AIMS: Previous studies reported a severely impaired energy balance in COPD patients during the first days of an acute exacerbation, mainly due to a decreased energy and protein intake. The aim of the study was to investigate the feasibility and effectiveness of energy- and protein-rich nutritional supplements during hospitalization for an acute exacerbation in nutritionally depleted COPD patients. METHODS: In a randomized double-blind, placebo-controlled two-center trial, 56 COPD patients were randomized and 47 patients completed the study. Nutritional intervention consisted of 3 x 125 ml (2.38 MJ/day) and the placebo group received similar amounts of a non-caloric fluid. Medical therapy and dietetic consultation were standardized and dietary intake was measured daily. Body composition, respiratory and skeletal muscle strength, lung function and symptoms were measured on admission and on days 4 and 8 of hospitalization. RESULTS: Forty-seven percent of the patients had experienced recent involuntary weight loss prior to admission. The degree of weight loss was inversely related to resting arterial oxygen tension (r = 0.31; P < 0.05). Nutritional intervention resulted in a significant increase in energy (16% vs. placebo) and protein intake (38% vs. placebo). Mean duration of hospitalization was 9 +/- 2 days. Relative to usual care, no additional improvements in lung function or muscle strength were seen after nutritional intervention. CONCLUSIONS: Oral nutritional supplementation during hospitalization for an acute exacerbation is feasible in nutritionally depleted COPD patients and does not interfere with normal dietary intake. SN - 0261-5614 UR - https://www.unboundmedicine.com/medline/citation/15380912/Nutritional_support_in_patients_with_chronic_obstructive_pulmonary_disease_during_hospitalization_for_an_acute_exacerbation L2 - https://linkinghub.elsevier.com/retrieve/pii/S026156140400055X DB - PRIME DP - Unbound Medicine ER -