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A role for L-glutamate ionotropic receptors in the development of rat neurogenic pulmonary edema.
Eur J Pharmacol. 2004 Sep 24; 499(3):257-63.EJ

Abstract

The present study was undertaken to evaluate possible roles of L-glutamate ionotropic receptors in neurogenic pulmonary edema. Perfusion of L-glutamate into the fourth ventricles of rats increased nitric oxide (NO) signals in the efflux solution concentration-dependently, significantly reducing both the occurrence and severity of neurogenic pulmonary edema. This effect was completely reversed by prior intracisternal injection of an NO synthase inhibitor, N(omega)-nitro-L-arginine methyl ester (L-NAME), or an N-methyl-D-aspartate (NMDA) receptor antagonist, dizocilpine maleate (MK-801), and partially by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), a 2-amino-3-hydroxy-5-methyl-4-isoxazol propionic acid (AMPA)/kainic acid receptor antagonist. Administration of MK-801 or CNQX alone, without L-glutamate, almost completely prevented neurogenic pulmonary edema development. These results suggest that endogenous L-glutamate may facilitate underlining disease process, whereas L-glutamate exogenously applied into the fourth ventricle may have an inhibitory action via release of NO, through ionotropic receptors.

Authors+Show Affiliations

Department of Anesthesiology, Nagoya University School of Medicine, Showa-ku, Nagoya 466-8550, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15381047

Citation

Kondo, Hiroko, et al. "A Role for L-glutamate Ionotropic Receptors in the Development of Rat Neurogenic Pulmonary Edema." European Journal of Pharmacology, vol. 499, no. 3, 2004, pp. 257-63.
Kondo H, Feng GG, Nishiwaki K, et al. A role for L-glutamate ionotropic receptors in the development of rat neurogenic pulmonary edema. Eur J Pharmacol. 2004;499(3):257-63.
Kondo, H., Feng, G. G., Nishiwaki, K., Shimada, Y., Hirokawa, M., Komatsu, T., Yokochi, T., & Ishikawa, N. (2004). A role for L-glutamate ionotropic receptors in the development of rat neurogenic pulmonary edema. European Journal of Pharmacology, 499(3), 257-63.
Kondo H, et al. A Role for L-glutamate Ionotropic Receptors in the Development of Rat Neurogenic Pulmonary Edema. Eur J Pharmacol. 2004 Sep 24;499(3):257-63. PubMed PMID: 15381047.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A role for L-glutamate ionotropic receptors in the development of rat neurogenic pulmonary edema. AU - Kondo,Hiroko, AU - Feng,Guo-Gang, AU - Nishiwaki,Kimitoshi, AU - Shimada,Yasuhiro, AU - Hirokawa,Mitsuru, AU - Komatsu,Toru, AU - Yokochi,Takashi, AU - Ishikawa,Naohisa, PY - 2004/03/11/received PY - 2004/07/08/revised PY - 2004/07/23/accepted PY - 2004/9/24/pubmed PY - 2005/1/26/medline PY - 2004/9/24/entrez SP - 257 EP - 63 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 499 IS - 3 N2 - The present study was undertaken to evaluate possible roles of L-glutamate ionotropic receptors in neurogenic pulmonary edema. Perfusion of L-glutamate into the fourth ventricles of rats increased nitric oxide (NO) signals in the efflux solution concentration-dependently, significantly reducing both the occurrence and severity of neurogenic pulmonary edema. This effect was completely reversed by prior intracisternal injection of an NO synthase inhibitor, N(omega)-nitro-L-arginine methyl ester (L-NAME), or an N-methyl-D-aspartate (NMDA) receptor antagonist, dizocilpine maleate (MK-801), and partially by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), a 2-amino-3-hydroxy-5-methyl-4-isoxazol propionic acid (AMPA)/kainic acid receptor antagonist. Administration of MK-801 or CNQX alone, without L-glutamate, almost completely prevented neurogenic pulmonary edema development. These results suggest that endogenous L-glutamate may facilitate underlining disease process, whereas L-glutamate exogenously applied into the fourth ventricle may have an inhibitory action via release of NO, through ionotropic receptors. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/15381047/A_role_for_L_glutamate_ionotropic_receptors_in_the_development_of_rat_neurogenic_pulmonary_edema_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(04)00869-6 DB - PRIME DP - Unbound Medicine ER -