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Influence of ferulic acid on circulatory prooxidant-antioxidant status during alcohol and PUFA induced toxicity.
J Physiol Pharmacol. 2004 Sep; 55(3):551-61.JP

Abstract

In recent years, there has been an escalation in alcohol abuse and inevitably, alcohol related disorders are becoming an increasingly important cause of morbidity and mortality. Alcohol is known to induce a dose dependent increase in lipid peroxidation. Alcohol related disabilities are more pronounced when taken along with diet rich in polyunsaturated fatty acid (PUFA). The present work aims at analysing the protective role of ferulic acid (FA), a naturally occurring nutritional component on alcohol and PUFA induced oxidative stress. Two different doses of ferulic acid, 20 mg/kg body weight and 40 mg /kg body weight were used for the study. The results showed that the levels of oxidative markers; thiobarbituric acid reactive substances (TBARS), hydroperoxides (HP) and levels of copper (Cu) and ferritin were increased significantly in plasma of alcohol, thermally oxidised PUFA (DeltaPUFA) and alcohol + DeltaPUFA groups, which were decreased significantly on treatment with both the doses of ferulic acid. The activities of enzymic antioxidants viz. superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and non enzymic antioxidants like vitamin C, vitamin E, and reduced glutathione (GSH) and the levels of zinc (Zn) were significantly decreased in alcohol, DeltaPUFA and alcohol + DeltaPUFA groups which were improved significantly on treatment with both the doses of FA. The reduction in oxidative stress was more significant in 20 mg/kg body weight treatment groups compared to 40 mg/kg body weight. Thus from the results obtained, we conclude that FA effectively protects the system against alcohol and PUFA induced oxidative stress.

Authors+Show Affiliations

Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15381826

Citation

Rukkumani, R, et al. "Influence of Ferulic Acid On Circulatory Prooxidant-antioxidant Status During Alcohol and PUFA Induced Toxicity." Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, vol. 55, no. 3, 2004, pp. 551-61.
Rukkumani R, Aruna K, Varma PS, et al. Influence of ferulic acid on circulatory prooxidant-antioxidant status during alcohol and PUFA induced toxicity. J Physiol Pharmacol. 2004;55(3):551-61.
Rukkumani, R., Aruna, K., Varma, P. S., & Menon, V. P. (2004). Influence of ferulic acid on circulatory prooxidant-antioxidant status during alcohol and PUFA induced toxicity. Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, 55(3), 551-61.
Rukkumani R, et al. Influence of Ferulic Acid On Circulatory Prooxidant-antioxidant Status During Alcohol and PUFA Induced Toxicity. J Physiol Pharmacol. 2004;55(3):551-61. PubMed PMID: 15381826.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of ferulic acid on circulatory prooxidant-antioxidant status during alcohol and PUFA induced toxicity. AU - Rukkumani,R, AU - Aruna,K, AU - Varma,P S, AU - Menon,V P, PY - 2004/01/19/received PY - 2004/08/02/accepted PY - 2004/9/24/pubmed PY - 2005/6/23/medline PY - 2004/9/24/entrez SP - 551 EP - 61 JF - Journal of physiology and pharmacology : an official journal of the Polish Physiological Society JO - J Physiol Pharmacol VL - 55 IS - 3 N2 - In recent years, there has been an escalation in alcohol abuse and inevitably, alcohol related disorders are becoming an increasingly important cause of morbidity and mortality. Alcohol is known to induce a dose dependent increase in lipid peroxidation. Alcohol related disabilities are more pronounced when taken along with diet rich in polyunsaturated fatty acid (PUFA). The present work aims at analysing the protective role of ferulic acid (FA), a naturally occurring nutritional component on alcohol and PUFA induced oxidative stress. Two different doses of ferulic acid, 20 mg/kg body weight and 40 mg /kg body weight were used for the study. The results showed that the levels of oxidative markers; thiobarbituric acid reactive substances (TBARS), hydroperoxides (HP) and levels of copper (Cu) and ferritin were increased significantly in plasma of alcohol, thermally oxidised PUFA (DeltaPUFA) and alcohol + DeltaPUFA groups, which were decreased significantly on treatment with both the doses of ferulic acid. The activities of enzymic antioxidants viz. superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and non enzymic antioxidants like vitamin C, vitamin E, and reduced glutathione (GSH) and the levels of zinc (Zn) were significantly decreased in alcohol, DeltaPUFA and alcohol + DeltaPUFA groups which were improved significantly on treatment with both the doses of FA. The reduction in oxidative stress was more significant in 20 mg/kg body weight treatment groups compared to 40 mg/kg body weight. Thus from the results obtained, we conclude that FA effectively protects the system against alcohol and PUFA induced oxidative stress. SN - 0867-5910 UR - https://www.unboundmedicine.com/medline/citation/15381826/Influence_of_ferulic_acid_on_circulatory_prooxidant_antioxidant_status_during_alcohol_and_PUFA_induced_toxicity_ L2 - http://www.jpp.krakow.pl/journal/archive/09_04/pdf/551_09_04_article.pdf DB - PRIME DP - Unbound Medicine ER -