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L-carnitine protects gastric mucosa by decreasing ischemia-reperfusion induced lipid peroxidation.
J Physiol Pharmacol. 2004 Sep; 55(3):595-606.JP

Abstract

Studies have shown that reactive oxygen metabolites and lipid peroxidation play important roles in ischemia-reperfusion injury in many organs such as heart, brain and stomach. The aim of this study is to evaluate the antioxidant effect of L-carnitine on gastric mucosal barrier, lipid peroxidation and the activities of antioxidant enzymes in rat gastric mucosa subjected to ischemia-reperfusion injury. Rats were subjected to 30 min of ischemia followed by 60 min of reperfusion. L-carnitine (100 mg/kg), was given to rats intravenously five minutes before the ischemia. In our experiment, lesion index, thiobarbituric acid reactive substances, prostaglandin E2 and mucus content in gastric tissue were measured. The results indicated that the lesion index and the formation of thiobarbituric acid reactive substances increased significantly with the ischemia-reperfusion injury in the gastric mucosa. L-carnitine treatment reduced these parameters to the values of sham operated rats. The tissue catalase and superoxide dismutase activities and prostaglandin E2 production decreased significantly in the gastric mucosa of rats exposed to ischemia-reperfusion. L-carnitine pretreatment increased the tissue catalase activity and prostaglandin E2 to the levels of sham-operated rats but did not change superoxide dismutase activity. There were no significant difference in glutathione peroxidase activity and mucus content between the groups in the gastric mucosa. In summary, L-carnitine pretreatment protected gastric mucosa from ischemia-reperfusion injury by its decreasing effect on lipid peroxidation and by preventing the decrease in prostaglandin E2 content of gastric mucosa.

Authors+Show Affiliations

Derin N
Faculty of Medicine, Department of Physiology, Akdeniz University, Antalya, Turkey. narinderin@akdeniz.edu.tr
Izgut-Uysal VN
No affiliation info available
Agac A
No affiliation info available
Aliciguzel Y
No affiliation info available
Demir N
No affiliation info available

MeSH

AnimalsCarnitineCatalaseDinoprostoneGastric MucosaGlutathione PeroxidaseGlycosaminoglycansIschemiaLipid PeroxidationMaleRatsRats, WistarReperfusion InjurySuperoxide DismutaseThiobarbituric Acid Reactive Substances

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15381830

Citation

Derin, N, et al. "L-carnitine Protects Gastric Mucosa By Decreasing Ischemia-reperfusion Induced Lipid Peroxidation." Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, vol. 55, no. 3, 2004, pp. 595-606.
Derin N, Izgut-Uysal VN, Agac A, et al. L-carnitine protects gastric mucosa by decreasing ischemia-reperfusion induced lipid peroxidation. J Physiol Pharmacol. 2004;55(3):595-606.
Derin, N., Izgut-Uysal, V. N., Agac, A., Aliciguzel, Y., & Demir, N. (2004). L-carnitine protects gastric mucosa by decreasing ischemia-reperfusion induced lipid peroxidation. Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, 55(3), 595-606.
Derin N, et al. L-carnitine Protects Gastric Mucosa By Decreasing Ischemia-reperfusion Induced Lipid Peroxidation. J Physiol Pharmacol. 2004;55(3):595-606. PubMed PMID: 15381830.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - L-carnitine protects gastric mucosa by decreasing ischemia-reperfusion induced lipid peroxidation. AU - Derin,N, AU - Izgut-Uysal,V N, AU - Agac,A, AU - Aliciguzel,Y, AU - Demir,N, PY - 2003/11/12/received PY - 2004/08/02/accepted PY - 2004/9/24/pubmed PY - 2005/6/23/medline PY - 2004/9/24/entrez SP - 595 EP - 606 JF - Journal of physiology and pharmacology : an official journal of the Polish Physiological Society JO - J Physiol Pharmacol VL - 55 IS - 3 N2 - Studies have shown that reactive oxygen metabolites and lipid peroxidation play important roles in ischemia-reperfusion injury in many organs such as heart, brain and stomach. The aim of this study is to evaluate the antioxidant effect of L-carnitine on gastric mucosal barrier, lipid peroxidation and the activities of antioxidant enzymes in rat gastric mucosa subjected to ischemia-reperfusion injury. Rats were subjected to 30 min of ischemia followed by 60 min of reperfusion. L-carnitine (100 mg/kg), was given to rats intravenously five minutes before the ischemia. In our experiment, lesion index, thiobarbituric acid reactive substances, prostaglandin E2 and mucus content in gastric tissue were measured. The results indicated that the lesion index and the formation of thiobarbituric acid reactive substances increased significantly with the ischemia-reperfusion injury in the gastric mucosa. L-carnitine treatment reduced these parameters to the values of sham operated rats. The tissue catalase and superoxide dismutase activities and prostaglandin E2 production decreased significantly in the gastric mucosa of rats exposed to ischemia-reperfusion. L-carnitine pretreatment increased the tissue catalase activity and prostaglandin E2 to the levels of sham-operated rats but did not change superoxide dismutase activity. There were no significant difference in glutathione peroxidase activity and mucus content between the groups in the gastric mucosa. In summary, L-carnitine pretreatment protected gastric mucosa from ischemia-reperfusion injury by its decreasing effect on lipid peroxidation and by preventing the decrease in prostaglandin E2 content of gastric mucosa. SN - 0867-5910 UR - https://www.unboundmedicine.com/medline/citation/15381830/L_carnitine_protects_gastric_mucosa_by_decreasing_ischemia_reperfusion_induced_lipid_peroxidation_ DB - PRIME DP - Unbound Medicine ER -