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[The obstructive sleep apnoea syndrome in obesity: a conspirator in the shadow].
Rev Med Univ Navarra. 2004 Apr-Jun; 48(2):55-62.RM

Abstract

The obstructive sleep apnoea syndrome (OSAS) is caused by upper airway collapse during sleep. These episodes are associated with recurrent oxyhaemoglobin desaturations and arousals which lead to disruption of the sleep pattern and cognitive deterioration. Factors such as age, male sex, menopause, tobacco and alcohol consumption and anatomic abnormalities are demonstrated risk factors for OSAS development. Obesity, specially of abdominal type, is also a very strong predictor of OSAS, increasing the risk of apnoea by ten times. OSAS prevalence may reach 80% and 50% en males and females with morbid obesity respectively. OSAS induces sympathoexcitation, insulin resistance, renin-angiotensin system activation, oxidative stress, endothelial dysfunction, hypercoagulability and reduction of fibrinolysis leading to hypertension and increased cardiovascular risk. The best diagnostic procedure is polysomnography. Obesity treatment is followed by a dramatic improvement in OSAS. Weight loss of 10% results in reductions of apnoea index by 26%. Application of a positive pressure system is a very effective treatment for OSAS which reduces the apnoea index and improves cardiovascular risk and cognitive impairment.

Authors+Show Affiliations

Salvador J
Departamento de Endocrinología y Nutrición, Clínica Universitaria de Navarra, Facultad de Medicina, Universidad de Navarra, Pamplona. jsalvador@unav.es
Iriarte J
No affiliation info available
Silva C
No affiliation info available
Gómez Ambrosi J
No affiliation info available
Díez Caballero A
No affiliation info available
Frühbeck G
No affiliation info available

MeSH

Cardiovascular DiseasesContinuous Positive Airway PressureFemaleHumansInsulin ResistanceLeptinMaleObesityOxidative StressPolysomnographyPrevalenceRisk FactorsSleep Apnea, ObstructiveSympathetic Nervous SystemThrombophiliaWeight Loss

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't
Review

Language

spa

PubMed ID

15382614

Citation

Salvador, J, et al. "[The Obstructive Sleep Apnoea Syndrome in Obesity: a Conspirator in the Shadow]." Revista De Medicina De La Universidad De Navarra, vol. 48, no. 2, 2004, pp. 55-62.
Salvador J, Iriarte J, Silva C, et al. [The obstructive sleep apnoea syndrome in obesity: a conspirator in the shadow]. Rev Med Univ Navarra. 2004;48(2):55-62.
Salvador, J., Iriarte, J., Silva, C., Gómez Ambrosi, J., Díez Caballero, A., & Frühbeck, G. (2004). [The obstructive sleep apnoea syndrome in obesity: a conspirator in the shadow]. Revista De Medicina De La Universidad De Navarra, 48(2), 55-62.
Salvador J, et al. [The Obstructive Sleep Apnoea Syndrome in Obesity: a Conspirator in the Shadow]. Rev Med Univ Navarra. 2004 Apr-Jun;48(2):55-62. PubMed PMID: 15382614.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The obstructive sleep apnoea syndrome in obesity: a conspirator in the shadow]. AU - Salvador,J, AU - Iriarte,J, AU - Silva,C, AU - Gómez Ambrosi,J, AU - Díez Caballero,A, AU - Frühbeck,G, PY - 2004/9/24/pubmed PY - 2004/10/9/medline PY - 2004/9/24/entrez SP - 55 EP - 62 JF - Revista de medicina de la Universidad de Navarra JO - Rev Med Univ Navarra VL - 48 IS - 2 N2 - The obstructive sleep apnoea syndrome (OSAS) is caused by upper airway collapse during sleep. These episodes are associated with recurrent oxyhaemoglobin desaturations and arousals which lead to disruption of the sleep pattern and cognitive deterioration. Factors such as age, male sex, menopause, tobacco and alcohol consumption and anatomic abnormalities are demonstrated risk factors for OSAS development. Obesity, specially of abdominal type, is also a very strong predictor of OSAS, increasing the risk of apnoea by ten times. OSAS prevalence may reach 80% and 50% en males and females with morbid obesity respectively. OSAS induces sympathoexcitation, insulin resistance, renin-angiotensin system activation, oxidative stress, endothelial dysfunction, hypercoagulability and reduction of fibrinolysis leading to hypertension and increased cardiovascular risk. The best diagnostic procedure is polysomnography. Obesity treatment is followed by a dramatic improvement in OSAS. Weight loss of 10% results in reductions of apnoea index by 26%. Application of a positive pressure system is a very effective treatment for OSAS which reduces the apnoea index and improves cardiovascular risk and cognitive impairment. SN - 0556-6177 UR - https://www.unboundmedicine.com/medline/citation/15382614/[The_obstructive_sleep_apnoea_syndrome_in_obesity:_a_conspirator_in_the_shadow]_ DB - PRIME DP - Unbound Medicine ER -