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Impact of the motor complications of Parkinson's disease on the quality of life.
Mov Disord. 2005 Feb; 20(2):224-30.MD

Abstract

The impact of motor complications of Parkinson's disease (PD), especially levodopa-induced dyskinesias, on quality of life (QL) was studied in 143 patients with PD. All were evaluated on the Hoehn and Yahr (H&Y) scale, and the Motor part of the Unified Parkinson's Disease Rating Scale (UPDRS). Motor complications were analyzed using the UPDRS Parts IV(A) and IV(B) and the Abnormal Involuntary Movement Scale. A specific Parkinson's disease quality of life questionnaire (39-item version, PDQ-39) was used. Motor complications significantly worsened the PDQ-39 Summary Index (PDQ-SI) of patients with PD. The dimensions of Mobility, Activities of Daily Living, Stigma, and Communication were the most strongly affected. "Peak dose" dyskinesia decreased Mobility, Emotional Well-Being, and Cognition, whereas biphasic dyskinesia affected Mobility, Stigma, Communication, and Activities of Daily Living. Morning akinesia, end-of-dose fluctuations, and "unpredictable offs" decreased QL on the dimensions of Mobility, Activities of Daily Living, Stigma, and Communication. Nocturnal akinesia led to a deterioration of all dimensions of the PDQ-39. Thus, motor complications and especially nocturnal akinesia and biphasic dyskinesias worsened the QL of PD patients.

Authors+Show Affiliations

Service de Neurologie, Centre Hospitalier Vichy, France. stephane.chapuis@ch-vichy.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15384126

Citation

Chapuis, Stéphane, et al. "Impact of the Motor Complications of Parkinson's Disease On the Quality of Life." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 20, no. 2, 2005, pp. 224-30.
Chapuis S, Ouchchane L, Metz O, et al. Impact of the motor complications of Parkinson's disease on the quality of life. Mov Disord. 2005;20(2):224-30.
Chapuis, S., Ouchchane, L., Metz, O., Gerbaud, L., & Durif, F. (2005). Impact of the motor complications of Parkinson's disease on the quality of life. Movement Disorders : Official Journal of the Movement Disorder Society, 20(2), 224-30.
Chapuis S, et al. Impact of the Motor Complications of Parkinson's Disease On the Quality of Life. Mov Disord. 2005;20(2):224-30. PubMed PMID: 15384126.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of the motor complications of Parkinson's disease on the quality of life. AU - Chapuis,Stéphane, AU - Ouchchane,Lemlih, AU - Metz,Olivier, AU - Gerbaud,Laurent, AU - Durif,Franck, PY - 2004/9/24/pubmed PY - 2005/4/26/medline PY - 2004/9/24/entrez SP - 224 EP - 30 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 20 IS - 2 N2 - The impact of motor complications of Parkinson's disease (PD), especially levodopa-induced dyskinesias, on quality of life (QL) was studied in 143 patients with PD. All were evaluated on the Hoehn and Yahr (H&Y) scale, and the Motor part of the Unified Parkinson's Disease Rating Scale (UPDRS). Motor complications were analyzed using the UPDRS Parts IV(A) and IV(B) and the Abnormal Involuntary Movement Scale. A specific Parkinson's disease quality of life questionnaire (39-item version, PDQ-39) was used. Motor complications significantly worsened the PDQ-39 Summary Index (PDQ-SI) of patients with PD. The dimensions of Mobility, Activities of Daily Living, Stigma, and Communication were the most strongly affected. "Peak dose" dyskinesia decreased Mobility, Emotional Well-Being, and Cognition, whereas biphasic dyskinesia affected Mobility, Stigma, Communication, and Activities of Daily Living. Morning akinesia, end-of-dose fluctuations, and "unpredictable offs" decreased QL on the dimensions of Mobility, Activities of Daily Living, Stigma, and Communication. Nocturnal akinesia led to a deterioration of all dimensions of the PDQ-39. Thus, motor complications and especially nocturnal akinesia and biphasic dyskinesias worsened the QL of PD patients. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/15384126/Impact_of_the_motor_complications_of_Parkinson's_disease_on_the_quality_of_life_ L2 - https://doi.org/10.1002/mds.20279 DB - PRIME DP - Unbound Medicine ER -