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Cigarette smoking and the risk of gastric cancer: a pooled analysis of two prospective studies in Japan.
Int J Cancer 2004; 112(6):1049-55IJ

Abstract

To examine the association between cigarette smoking and the risk of gastric cancer, we conducted a pooled analysis of 2 population-based prospective cohort studies in rural northern Japan. Cohort 1 included 9,980 men (>or=40 years old) and Cohort 2 included 19,412 men (40-64 years old). The subjects completed a self-administered questionnaire on cigarette smoking and other health habits. We identified 228 cases of gastric cancer among Cohort 1 subjects (9 years of follow-up with 74,073 person-years) and 223 among Cohort 2 subjects (7 years of follow-up with 141,675 person-years). From each cohort, we computed the relative risk (RR) and 95% confidence interval (CI) of gastric cancer associated with smoking using a Cox regression analysis and pooled these estimates to obtain summary measures. The pooled multivariate RRs (95% CIs) for current smokers and past smokers compared to subjects who had never smoked were 1.84 (1.39-2.43) and 1.77 (1.29-2.43), respectively. The higher number of cigarettes smoked per day among current smokers was associated with a linear increase in risk (trend p < 0.05). The significant increase in risk for past smokers remained for up to 14 years after cessation. An increased risk was noted for cancer of the antrum but not for cardia or body lesions. The risk was increased for both differentiated and nondifferentiated histologic subtypes. Our findings support the hypothesis that cigarette smoking is a risk factor for gastric cancer.

Authors+Show Affiliations

Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan. aglaia-thk@umin.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

15386347

Citation

Koizumi, Yayoi, et al. "Cigarette Smoking and the Risk of Gastric Cancer: a Pooled Analysis of Two Prospective Studies in Japan." International Journal of Cancer, vol. 112, no. 6, 2004, pp. 1049-55.
Koizumi Y, Tsubono Y, Nakaya N, et al. Cigarette smoking and the risk of gastric cancer: a pooled analysis of two prospective studies in Japan. Int J Cancer. 2004;112(6):1049-55.
Koizumi, Y., Tsubono, Y., Nakaya, N., Kuriyama, S., Shibuya, D., Matsuoka, H., & Tsuji, I. (2004). Cigarette smoking and the risk of gastric cancer: a pooled analysis of two prospective studies in Japan. International Journal of Cancer, 112(6), pp. 1049-55.
Koizumi Y, et al. Cigarette Smoking and the Risk of Gastric Cancer: a Pooled Analysis of Two Prospective Studies in Japan. Int J Cancer. 2004 Dec 20;112(6):1049-55. PubMed PMID: 15386347.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cigarette smoking and the risk of gastric cancer: a pooled analysis of two prospective studies in Japan. AU - Koizumi,Yayoi, AU - Tsubono,Yoshitaka, AU - Nakaya,Naoki, AU - Kuriyama,Shinichi, AU - Shibuya,Daisuke, AU - Matsuoka,Hiroo, AU - Tsuji,Ichiro, PY - 2004/9/24/pubmed PY - 2004/12/16/medline PY - 2004/9/24/entrez SP - 1049 EP - 55 JF - International journal of cancer JO - Int. J. Cancer VL - 112 IS - 6 N2 - To examine the association between cigarette smoking and the risk of gastric cancer, we conducted a pooled analysis of 2 population-based prospective cohort studies in rural northern Japan. Cohort 1 included 9,980 men (>or=40 years old) and Cohort 2 included 19,412 men (40-64 years old). The subjects completed a self-administered questionnaire on cigarette smoking and other health habits. We identified 228 cases of gastric cancer among Cohort 1 subjects (9 years of follow-up with 74,073 person-years) and 223 among Cohort 2 subjects (7 years of follow-up with 141,675 person-years). From each cohort, we computed the relative risk (RR) and 95% confidence interval (CI) of gastric cancer associated with smoking using a Cox regression analysis and pooled these estimates to obtain summary measures. The pooled multivariate RRs (95% CIs) for current smokers and past smokers compared to subjects who had never smoked were 1.84 (1.39-2.43) and 1.77 (1.29-2.43), respectively. The higher number of cigarettes smoked per day among current smokers was associated with a linear increase in risk (trend p < 0.05). The significant increase in risk for past smokers remained for up to 14 years after cessation. An increased risk was noted for cancer of the antrum but not for cardia or body lesions. The risk was increased for both differentiated and nondifferentiated histologic subtypes. Our findings support the hypothesis that cigarette smoking is a risk factor for gastric cancer. SN - 0020-7136 UR - https://www.unboundmedicine.com/medline/citation/15386347/Cigarette_smoking_and_the_risk_of_gastric_cancer:_a_pooled_analysis_of_two_prospective_studies_in_Japan_ L2 - https://doi.org/10.1002/ijc.20518 DB - PRIME DP - Unbound Medicine ER -