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Alcohol consumption and risk of prostate cancer in middle-aged men.
Int J Cancer 2005; 113(1):133-40IJ

Abstract

Alcohol consumption is a modifiable lifestyle factor that may affect prostate cancer risk. Alcohol alters the hormonal milieu and contains chemical substances such as flavonoids (red wine), which may alter tumor cell growth. Data from a population-based case-control study in King County, WA, were utilized to evaluate the association of alcohol consumption with prostate cancer in middle-aged men. A total of 753 newly diagnosed prostate cancer cases, 40-64 years of age, participated in the study. Seven hundred three control subjects, frequency matched to cases by age, were selected through random digit dialing. All participants completed an in-person interview on lifetime alcohol consumption and other risk factors for prostate cancer. Logistic regression models were used to estimate odds ratios (OR) and assess significance (95% confidence intervals [CI]). All tests of statistical significance were two-sided. No clear association with prostate cancer risk was seen for overall alcohol consumption. Each additional glass of red wine consumed per week showed a statistically significant 6% decrease in relative risk (OR = 0.94; 95% CI = 0.90-0.98), and there was evidence for a decline in risk estimates across increasing categories of red wine intake (trend p = 0.02). No clear associations were seen for consumption of beer or liquor. Our present study suggests that consumption of beer or liquor is not associated with prostate cancer. There may be, however, a reduced relative risk associated with increasing level of red wine consumption. Further research is needed to evaluate the potential negative association between red wine intake and prostate cancer risk.

Authors+Show Affiliations

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15386436

Citation

Schoonen, W Marieke, et al. "Alcohol Consumption and Risk of Prostate Cancer in Middle-aged Men." International Journal of Cancer, vol. 113, no. 1, 2005, pp. 133-40.
Schoonen WM, Salinas CA, Kiemeney LA, et al. Alcohol consumption and risk of prostate cancer in middle-aged men. Int J Cancer. 2005;113(1):133-40.
Schoonen, W. M., Salinas, C. A., Kiemeney, L. A., & Stanford, J. L. (2005). Alcohol consumption and risk of prostate cancer in middle-aged men. International Journal of Cancer, 113(1), pp. 133-40.
Schoonen WM, et al. Alcohol Consumption and Risk of Prostate Cancer in Middle-aged Men. Int J Cancer. 2005 Jan 1;113(1):133-40. PubMed PMID: 15386436.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol consumption and risk of prostate cancer in middle-aged men. AU - Schoonen,W Marieke, AU - Salinas,Claudia A, AU - Kiemeney,Lambertus A L M, AU - Stanford,Janet L, PY - 2004/9/24/pubmed PY - 2004/12/16/medline PY - 2004/9/24/entrez SP - 133 EP - 40 JF - International journal of cancer JO - Int. J. Cancer VL - 113 IS - 1 N2 - Alcohol consumption is a modifiable lifestyle factor that may affect prostate cancer risk. Alcohol alters the hormonal milieu and contains chemical substances such as flavonoids (red wine), which may alter tumor cell growth. Data from a population-based case-control study in King County, WA, were utilized to evaluate the association of alcohol consumption with prostate cancer in middle-aged men. A total of 753 newly diagnosed prostate cancer cases, 40-64 years of age, participated in the study. Seven hundred three control subjects, frequency matched to cases by age, were selected through random digit dialing. All participants completed an in-person interview on lifetime alcohol consumption and other risk factors for prostate cancer. Logistic regression models were used to estimate odds ratios (OR) and assess significance (95% confidence intervals [CI]). All tests of statistical significance were two-sided. No clear association with prostate cancer risk was seen for overall alcohol consumption. Each additional glass of red wine consumed per week showed a statistically significant 6% decrease in relative risk (OR = 0.94; 95% CI = 0.90-0.98), and there was evidence for a decline in risk estimates across increasing categories of red wine intake (trend p = 0.02). No clear associations were seen for consumption of beer or liquor. Our present study suggests that consumption of beer or liquor is not associated with prostate cancer. There may be, however, a reduced relative risk associated with increasing level of red wine consumption. Further research is needed to evaluate the potential negative association between red wine intake and prostate cancer risk. SN - 0020-7136 UR - https://www.unboundmedicine.com/medline/citation/15386436/Alcohol_consumption_and_risk_of_prostate_cancer_in_middle_aged_men_ L2 - https://doi.org/10.1002/ijc.20528 DB - PRIME DP - Unbound Medicine ER -