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Highly enantioselective asymmetric hydrogenation of beta-acetamido dehydroamino acid derivatives using a three-hindered quadrant rhodium catalyst.
Org Lett. 2004 Sep 30; 6(20):3645-7.OL

Abstract

[reaction: see text] A previously reported three-hindered quadrant chiral ligand and its corresponding rhodium complex provide high enantioselectivity for the asymmetric hydrogenation of beta-acetamido dehydroamino acid substrates. Both (E)- and (Z)-substrates are hydrogenated with high enantioselectivity in all of the reported examples. Asymmetric hydrogenation of a cyclic beta-acetamido dehydroamino acid substrate in 85% ee is also reported.

Authors+Show Affiliations

Pfizer, Inc., 2800 Plymouth Road, Ann Arbor, Michigan 48105, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15387569

Citation

Wu, He-Ping, and Garrett Hoge. "Highly Enantioselective Asymmetric Hydrogenation of Beta-acetamido Dehydroamino Acid Derivatives Using a Three-hindered Quadrant Rhodium Catalyst." Organic Letters, vol. 6, no. 20, 2004, pp. 3645-7.
Wu HP, Hoge G. Highly enantioselective asymmetric hydrogenation of beta-acetamido dehydroamino acid derivatives using a three-hindered quadrant rhodium catalyst. Org Lett. 2004;6(20):3645-7.
Wu, H. P., & Hoge, G. (2004). Highly enantioselective asymmetric hydrogenation of beta-acetamido dehydroamino acid derivatives using a three-hindered quadrant rhodium catalyst. Organic Letters, 6(20), 3645-7.
Wu HP, Hoge G. Highly Enantioselective Asymmetric Hydrogenation of Beta-acetamido Dehydroamino Acid Derivatives Using a Three-hindered Quadrant Rhodium Catalyst. Org Lett. 2004 Sep 30;6(20):3645-7. PubMed PMID: 15387569.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Highly enantioselective asymmetric hydrogenation of beta-acetamido dehydroamino acid derivatives using a three-hindered quadrant rhodium catalyst. AU - Wu,He-Ping, AU - Hoge,Garrett, PY - 2004/9/25/pubmed PY - 2005/11/1/medline PY - 2004/9/25/entrez SP - 3645 EP - 7 JF - Organic letters JO - Org Lett VL - 6 IS - 20 N2 - [reaction: see text] A previously reported three-hindered quadrant chiral ligand and its corresponding rhodium complex provide high enantioselectivity for the asymmetric hydrogenation of beta-acetamido dehydroamino acid substrates. Both (E)- and (Z)-substrates are hydrogenated with high enantioselectivity in all of the reported examples. Asymmetric hydrogenation of a cyclic beta-acetamido dehydroamino acid substrate in 85% ee is also reported. SN - 1523-7060 UR - https://www.unboundmedicine.com/medline/citation/15387569/Highly_enantioselective_asymmetric_hydrogenation_of_beta_acetamido_dehydroamino_acid_derivatives_using_a_three_hindered_quadrant_rhodium_catalyst_ L2 - https://doi.org/10.1021/ol048386w DB - PRIME DP - Unbound Medicine ER -
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