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Cytotoxic sesquiterpene lactones from Eupatorium lindleyanum.
J Nat Prod. 2004 Sep; 67(9):1470-5.JN

Abstract

Ten new guaiane type sesquiterpene lactones, namely, eupalinilides A-J (1-10), as well as nine known compounds, eupachinilide C (11), eupachifolin D (12), eupachinilide E (13), 2alpha-hydroxyeupatolide (14), 3-deacetyleupalinin A (15), heliangine (16), 8beta-tigloyloxy-2,3-seco-6betaH,7alphaH-helianga-4Z,11(13)-diene-3,10beta;6, 12-diolid-2-oic acid (17), 8beta-(4'-hydroxytigloyloxy)-3beta,14-dihydroxy-6betaH,7alphaH-germacra-1(10)Z,4Z,11(13)-trien-6,12-olide (18), and 8beta-tigloyloxy-3beta,14-dihydroxy-6betaH,7alphaH-germacra-1(10)Z,4E,11(13)-trien-6,12-olide (19), were isolated from the whole plant of Eupatorium lindleyanum. Eupalinilides B (2), C (3), E (5), F (6), and I (9) have been tested for cytotoxicity against P-388 and A-549 tumor cell lines. The results showed that eupalinilides B (2) and E (5) demonstrated potent cytotoxicity. The structures of these compounds were determined by spectroscopic methods including 1D and 2D NMR spectra.

Authors+Show Affiliations

Huo J
State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
Yang SP
No affiliation info available
Ding J
No affiliation info available
Yue JM
No affiliation info available

MeSH

AnimalsAntineoplastic Agents, PhytogenicChinaDrug Screening Assays, AntitumorEupatoriumHumansLactonesLeukemia P388MiceMolecular StructureNuclear Magnetic Resonance, BiomolecularPlants, MedicinalSesquiterpenesStereoisomerismTumor Cells, Cultured

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15387644

Citation

Huo, Jun, et al. "Cytotoxic Sesquiterpene Lactones From Eupatorium Lindleyanum." Journal of Natural Products, vol. 67, no. 9, 2004, pp. 1470-5.
Huo J, Yang SP, Ding J, et al. Cytotoxic sesquiterpene lactones from Eupatorium lindleyanum. J Nat Prod. 2004;67(9):1470-5.
Huo, J., Yang, S. P., Ding, J., & Yue, J. M. (2004). Cytotoxic sesquiterpene lactones from Eupatorium lindleyanum. Journal of Natural Products, 67(9), 1470-5.
Huo J, et al. Cytotoxic Sesquiterpene Lactones From Eupatorium Lindleyanum. J Nat Prod. 2004;67(9):1470-5. PubMed PMID: 15387644.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytotoxic sesquiterpene lactones from Eupatorium lindleyanum. AU - Huo,Jun, AU - Yang,Sheng-Ping, AU - Ding,Jian, AU - Yue,Jian-Min, PY - 2004/9/25/pubmed PY - 2004/12/16/medline PY - 2004/9/25/entrez SP - 1470 EP - 5 JF - Journal of natural products JO - J Nat Prod VL - 67 IS - 9 N2 - Ten new guaiane type sesquiterpene lactones, namely, eupalinilides A-J (1-10), as well as nine known compounds, eupachinilide C (11), eupachifolin D (12), eupachinilide E (13), 2alpha-hydroxyeupatolide (14), 3-deacetyleupalinin A (15), heliangine (16), 8beta-tigloyloxy-2,3-seco-6betaH,7alphaH-helianga-4Z,11(13)-diene-3,10beta;6, 12-diolid-2-oic acid (17), 8beta-(4'-hydroxytigloyloxy)-3beta,14-dihydroxy-6betaH,7alphaH-germacra-1(10)Z,4Z,11(13)-trien-6,12-olide (18), and 8beta-tigloyloxy-3beta,14-dihydroxy-6betaH,7alphaH-germacra-1(10)Z,4E,11(13)-trien-6,12-olide (19), were isolated from the whole plant of Eupatorium lindleyanum. Eupalinilides B (2), C (3), E (5), F (6), and I (9) have been tested for cytotoxicity against P-388 and A-549 tumor cell lines. The results showed that eupalinilides B (2) and E (5) demonstrated potent cytotoxicity. The structures of these compounds were determined by spectroscopic methods including 1D and 2D NMR spectra. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/15387644/Cytotoxic_sesquiterpene_lactones_from_Eupatorium_lindleyanum_ DB - PRIME DP - Unbound Medicine ER -