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IL-17 and IL-17F modulate GM-CSF production by lung microvascular endothelial cells stimulated with IL-1beta and/or TNF-alpha.
Immunol Lett. 2004 Sep; 95(2):175-84.IL

Abstract

In this study, we investigated the roles of CD4 T cell cytokines IL-17 and IL-17F in GM-CSF production from lung microvascular endothelial cells (LMVECs). While a wide range of doses of IL-17 or IL-17F alone did not induce GM-CSF release from LMVECs, IL-17 had an enhancing effect on macrophage-derived IL-1beta- and TNF-alpha-induced GM-CSF mRNA expression and production, whereas IL-17F had an enhancing effect on IL-1beta-induced GM-CSF production, but a marked inhibitory effect on TNF-alpha-induced secretion. GM-CSF production was further enhanced with the combination of three cytokines IL-1beta, TNF-alpha and IL-17 or IL-17F. Additionally, when Th1 or Th2 cytokine was combined with IL-1beta or TNF-alpha, both Th1 and Th2 cytokines had a modest stimulatory effect on TNF-alpha-induced GM-CSF production, whereas IL-4 and IFN-gamma profoundly attenuated IL-1beta-induced secretion. Moreover, the regulation by IL-17 plus Th1 or Th2 cytokine of GM-CSF production from LMVECs treated with IL-1beta or TNF-alpha was dependent on the concentration of IL-17. Our findings indicate that IL-17 and IL-17F play a differential regulatory role in GM-CSF production by LMVECs stimulated with IL-1beta and/or TNF-alpha, which is sensitive to Th1 and Th2 cytokine modulation.

Authors+Show Affiliations

Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan. numasaki77@aol.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15388258

Citation

Numasaki, Muneo, et al. "IL-17 and IL-17F Modulate GM-CSF Production By Lung Microvascular Endothelial Cells Stimulated With IL-1beta And/or TNF-alpha." Immunology Letters, vol. 95, no. 2, 2004, pp. 175-84.
Numasaki M, Tomioka Y, Takahashi H, et al. IL-17 and IL-17F modulate GM-CSF production by lung microvascular endothelial cells stimulated with IL-1beta and/or TNF-alpha. Immunol Lett. 2004;95(2):175-84.
Numasaki, M., Tomioka, Y., Takahashi, H., & Sasaki, H. (2004). IL-17 and IL-17F modulate GM-CSF production by lung microvascular endothelial cells stimulated with IL-1beta and/or TNF-alpha. Immunology Letters, 95(2), 175-84.
Numasaki M, et al. IL-17 and IL-17F Modulate GM-CSF Production By Lung Microvascular Endothelial Cells Stimulated With IL-1beta And/or TNF-alpha. Immunol Lett. 2004;95(2):175-84. PubMed PMID: 15388258.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - IL-17 and IL-17F modulate GM-CSF production by lung microvascular endothelial cells stimulated with IL-1beta and/or TNF-alpha. AU - Numasaki,Muneo, AU - Tomioka,Yoshihisa, AU - Takahashi,Hidenori, AU - Sasaki,Hidetada, PY - 2004/05/18/received PY - 2004/07/08/revised PY - 2004/07/12/accepted PY - 2004/9/25/pubmed PY - 2005/4/21/medline PY - 2004/9/25/entrez SP - 175 EP - 84 JF - Immunology letters JO - Immunol Lett VL - 95 IS - 2 N2 - In this study, we investigated the roles of CD4 T cell cytokines IL-17 and IL-17F in GM-CSF production from lung microvascular endothelial cells (LMVECs). While a wide range of doses of IL-17 or IL-17F alone did not induce GM-CSF release from LMVECs, IL-17 had an enhancing effect on macrophage-derived IL-1beta- and TNF-alpha-induced GM-CSF mRNA expression and production, whereas IL-17F had an enhancing effect on IL-1beta-induced GM-CSF production, but a marked inhibitory effect on TNF-alpha-induced secretion. GM-CSF production was further enhanced with the combination of three cytokines IL-1beta, TNF-alpha and IL-17 or IL-17F. Additionally, when Th1 or Th2 cytokine was combined with IL-1beta or TNF-alpha, both Th1 and Th2 cytokines had a modest stimulatory effect on TNF-alpha-induced GM-CSF production, whereas IL-4 and IFN-gamma profoundly attenuated IL-1beta-induced secretion. Moreover, the regulation by IL-17 plus Th1 or Th2 cytokine of GM-CSF production from LMVECs treated with IL-1beta or TNF-alpha was dependent on the concentration of IL-17. Our findings indicate that IL-17 and IL-17F play a differential regulatory role in GM-CSF production by LMVECs stimulated with IL-1beta and/or TNF-alpha, which is sensitive to Th1 and Th2 cytokine modulation. SN - 0165-2478 UR - https://www.unboundmedicine.com/medline/citation/15388258/IL_17_and_IL_17F_modulate_GM_CSF_production_by_lung_microvascular_endothelial_cells_stimulated_with_IL_1beta_and/or_TNF_alpha_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-2478(04)00193-2 DB - PRIME DP - Unbound Medicine ER -