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The diagnostic accuracy of the atopy patch test in diagnosing hypersensitivity to cow's milk and hen's egg in unselected children with and without atopic dermatitis.
J Am Acad Dermatol 2004; 51(4):556-62JA

Abstract

BACKGROUND

Previous studies have suggested that the atopy patch test (APT) may make oral challenge superfluous in diagnosing children with food hypersensitivity.

OBJECTIVE

To investigate the clinical relevance of APT in predicting hypersensitivity to cow's milk and hen's egg in 486 unselected children 3 years of age.

METHOD

The children were examined by APT, skin prick (SPT), histamine release (HR), and specific IgE followed by oral challenge when hypersensitivity to cow's milk or hen's egg was suspected.

RESULTS

Food hypersensitivity confirmed by oral challenge was 1.6% to hen's egg and 0.6% to cow's milk. No hypersensitivity to cow's milk or hen's egg was predicted by APT alone.

CONCLUSION

APT could not predict food hypersensitivity not predicted by SPT, HR, or specific IgE. Thus, APT cannot be recommended in daily practice for the diagnosis of hypersensitivity to cow's milk and hen's egg in children 3 years of age.

Authors+Show Affiliations

Allergy Center, Department of Dermatology, Odense University Hospital Denmark. morten.oesterballe@allergi.sdu.dkNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15389190

Citation

Osterballe, Morten, et al. "The Diagnostic Accuracy of the Atopy Patch Test in Diagnosing Hypersensitivity to Cow's Milk and Hen's Egg in Unselected Children With and Without Atopic Dermatitis." Journal of the American Academy of Dermatology, vol. 51, no. 4, 2004, pp. 556-62.
Osterballe M, Andersen KE, Bindslev-Jensen C. The diagnostic accuracy of the atopy patch test in diagnosing hypersensitivity to cow's milk and hen's egg in unselected children with and without atopic dermatitis. J Am Acad Dermatol. 2004;51(4):556-62.
Osterballe, M., Andersen, K. E., & Bindslev-Jensen, C. (2004). The diagnostic accuracy of the atopy patch test in diagnosing hypersensitivity to cow's milk and hen's egg in unselected children with and without atopic dermatitis. Journal of the American Academy of Dermatology, 51(4), pp. 556-62.
Osterballe M, Andersen KE, Bindslev-Jensen C. The Diagnostic Accuracy of the Atopy Patch Test in Diagnosing Hypersensitivity to Cow's Milk and Hen's Egg in Unselected Children With and Without Atopic Dermatitis. J Am Acad Dermatol. 2004;51(4):556-62. PubMed PMID: 15389190.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The diagnostic accuracy of the atopy patch test in diagnosing hypersensitivity to cow's milk and hen's egg in unselected children with and without atopic dermatitis. AU - Osterballe,Morten, AU - Andersen,Klaus E, AU - Bindslev-Jensen,Carsten, PY - 2004/9/25/pubmed PY - 2005/4/12/medline PY - 2004/9/25/entrez SP - 556 EP - 62 JF - Journal of the American Academy of Dermatology JO - J. Am. Acad. Dermatol. VL - 51 IS - 4 N2 - BACKGROUND: Previous studies have suggested that the atopy patch test (APT) may make oral challenge superfluous in diagnosing children with food hypersensitivity. OBJECTIVE: To investigate the clinical relevance of APT in predicting hypersensitivity to cow's milk and hen's egg in 486 unselected children 3 years of age. METHOD: The children were examined by APT, skin prick (SPT), histamine release (HR), and specific IgE followed by oral challenge when hypersensitivity to cow's milk or hen's egg was suspected. RESULTS: Food hypersensitivity confirmed by oral challenge was 1.6% to hen's egg and 0.6% to cow's milk. No hypersensitivity to cow's milk or hen's egg was predicted by APT alone. CONCLUSION: APT could not predict food hypersensitivity not predicted by SPT, HR, or specific IgE. Thus, APT cannot be recommended in daily practice for the diagnosis of hypersensitivity to cow's milk and hen's egg in children 3 years of age. SN - 1097-6787 UR - https://www.unboundmedicine.com/medline/citation/15389190/The_diagnostic_accuracy_of_the_atopy_patch_test_in_diagnosing_hypersensitivity_to_cow's_milk_and_hen's_egg_in_unselected_children_with_and_without_atopic_dermatitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0190962204008370 DB - PRIME DP - Unbound Medicine ER -