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Lack of relationship between Doppler indices of diastolic function and left ventricular pressure transients in patients with definite diastolic heart failure.
Am Heart J 2004; 148(3):E12AH

Abstract

OBJECTIVES

The purpose of this study was to compare invasive with noninvasive indices of diastolic function in a well-defined group of patients with diastolic dysfunction and a history of diastolic heart failure.

BACKGROUND

Patients with heart failure and a normal left ventricular (LV) ejection fraction comprise a very large portion of the heart failure population and most are thought to have diastolic heart failure. While clinical and Doppler criteria for diastolic dysfunction and diastolic heart failure have been developed, there remains some controversy about the need for invasive cardiac catheterization and/or echo-Doppler evaluation of LV diastolic function. To date, there is no consensus as to the utility of these 2 methods in the diagnosis of diastolic heart failure.

METHODS

Forty-seven patients (mean age 58 +/- 11 years) with a history of congestive heart failure and preserved ejection fraction (> or =50%) by echocardiography underwent a combined hemodynamic/echo-Doppler study. Patients with coronary disease were excluded. Invasive parameters of LV diastolic function (tau, LV diastolic pressures) and Doppler parameters (peak E, peak A, E/A ratio, isovolumic relaxation time, and E deceleration time) were measured using standard techniques.

RESULTS

There was a close correlation between invasively-determined parameters (tau vs end diastolic pressure: r = 0.62, P <.001). The relationships between standard Doppler parameters and LV diastolic pressures were uniformly poor. However, the relationship between Doppler isovolumic relaxation time and tau improved considerably when patients were subgrouped by hemodynamic load.

CONCLUSIONS

Standard echo-Doppler indices of diastolic function correlate poorly with LV diastolic pressure transients. The diagnosis of diastolic heart failure cannot be made on the basis of a single echo-Doppler parameter but, rather, all parameters must be examined in concert and used in combination with clinical observations.

Authors+Show Affiliations

Department of Medicine, Division of Cardiology, University of Massachusetts Medical School, Worcester, Mass 01655, USA. aurigemg@ummhc.orgNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15389248

Citation

Aurigemma, Gerard P., et al. "Lack of Relationship Between Doppler Indices of Diastolic Function and Left Ventricular Pressure Transients in Patients With Definite Diastolic Heart Failure." American Heart Journal, vol. 148, no. 3, 2004, pp. E12.
Aurigemma GP, Zile MR, Gaasch WH. Lack of relationship between Doppler indices of diastolic function and left ventricular pressure transients in patients with definite diastolic heart failure. Am Heart J. 2004;148(3):E12.
Aurigemma, G. P., Zile, M. R., & Gaasch, W. H. (2004). Lack of relationship between Doppler indices of diastolic function and left ventricular pressure transients in patients with definite diastolic heart failure. American Heart Journal, 148(3), pp. E12.
Aurigemma GP, Zile MR, Gaasch WH. Lack of Relationship Between Doppler Indices of Diastolic Function and Left Ventricular Pressure Transients in Patients With Definite Diastolic Heart Failure. Am Heart J. 2004;148(3):E12. PubMed PMID: 15389248.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lack of relationship between Doppler indices of diastolic function and left ventricular pressure transients in patients with definite diastolic heart failure. AU - Aurigemma,Gerard P, AU - Zile,Michael R, AU - Gaasch,William H, PY - 2004/9/25/pubmed PY - 2004/12/17/medline PY - 2004/9/25/entrez SP - E12 EP - E12 JF - American heart journal JO - Am. Heart J. VL - 148 IS - 3 N2 - OBJECTIVES: The purpose of this study was to compare invasive with noninvasive indices of diastolic function in a well-defined group of patients with diastolic dysfunction and a history of diastolic heart failure. BACKGROUND: Patients with heart failure and a normal left ventricular (LV) ejection fraction comprise a very large portion of the heart failure population and most are thought to have diastolic heart failure. While clinical and Doppler criteria for diastolic dysfunction and diastolic heart failure have been developed, there remains some controversy about the need for invasive cardiac catheterization and/or echo-Doppler evaluation of LV diastolic function. To date, there is no consensus as to the utility of these 2 methods in the diagnosis of diastolic heart failure. METHODS: Forty-seven patients (mean age 58 +/- 11 years) with a history of congestive heart failure and preserved ejection fraction (> or =50%) by echocardiography underwent a combined hemodynamic/echo-Doppler study. Patients with coronary disease were excluded. Invasive parameters of LV diastolic function (tau, LV diastolic pressures) and Doppler parameters (peak E, peak A, E/A ratio, isovolumic relaxation time, and E deceleration time) were measured using standard techniques. RESULTS: There was a close correlation between invasively-determined parameters (tau vs end diastolic pressure: r = 0.62, P <.001). The relationships between standard Doppler parameters and LV diastolic pressures were uniformly poor. However, the relationship between Doppler isovolumic relaxation time and tau improved considerably when patients were subgrouped by hemodynamic load. CONCLUSIONS: Standard echo-Doppler indices of diastolic function correlate poorly with LV diastolic pressure transients. The diagnosis of diastolic heart failure cannot be made on the basis of a single echo-Doppler parameter but, rather, all parameters must be examined in concert and used in combination with clinical observations. SN - 1097-6744 UR - https://www.unboundmedicine.com/medline/citation/15389248/Lack_of_relationship_between_Doppler_indices_of_diastolic_function_and_left_ventricular_pressure_transients_in_patients_with_definite_diastolic_heart_failure_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002870304001322 DB - PRIME DP - Unbound Medicine ER -