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Amino acid metabolism in the Zucker diabetic fatty rat: effects of insulin resistance and of type 2 diabetes.
Can J Physiol Pharmacol 2004; 82(7):506-14CJ

Abstract

We investigated amino acid metabolism in the Zucker diabetic fatty (ZDF Gmi fa/fa) rat during the prediabetic insulin-resistant stage and the frank type 2 diabetic stage. Amino acids were measured in plasma, liver, and skeletal muscle, and the ratios of plasma/liver and plasma/skeletal muscle were calculated. At the insulin-resistant stage, the plasma concentrations of the gluconeogenic amino acids aspartate, serine, glutamine, glycine, and histidine were decreased in the ZDF Gmi fa/fa rats, whereas taurine, alpha-aminoadipic acid, methionine, phenylalanine, tryptophan, and the 3 branched-chain amino acids were significantly increased. At the diabetic stage, a larger number of gluconeogenic amino acids had decreased plasma concentrations. The 3 branched-chain amino acids had elevated plasma concentrations. In the liver and the skeletal muscles, concentrations of many of the gluconeogenic amino acids were lower at both stages, whereas the levels of 1 or all of the branched-chain amino acids were elevated. These changes in amino acid concentrations are similar to changes seen in type 1 diabetes. It is evident that insulin resistance alone is capable of bringing about many of the changes in amino acid metabolism observed in type 2 diabetes.

Authors+Show Affiliations

Department of Biochemistry, Memorial University of Newfoundland, St. John's, Canada.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15389298

Citation

Wijekoon, Enoka P., et al. "Amino Acid Metabolism in the Zucker Diabetic Fatty Rat: Effects of Insulin Resistance and of Type 2 Diabetes." Canadian Journal of Physiology and Pharmacology, vol. 82, no. 7, 2004, pp. 506-14.
Wijekoon EP, Skinner C, Brosnan ME, et al. Amino acid metabolism in the Zucker diabetic fatty rat: effects of insulin resistance and of type 2 diabetes. Can J Physiol Pharmacol. 2004;82(7):506-14.
Wijekoon, E. P., Skinner, C., Brosnan, M. E., & Brosnan, J. T. (2004). Amino acid metabolism in the Zucker diabetic fatty rat: effects of insulin resistance and of type 2 diabetes. Canadian Journal of Physiology and Pharmacology, 82(7), pp. 506-14.
Wijekoon EP, et al. Amino Acid Metabolism in the Zucker Diabetic Fatty Rat: Effects of Insulin Resistance and of Type 2 Diabetes. Can J Physiol Pharmacol. 2004;82(7):506-14. PubMed PMID: 15389298.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Amino acid metabolism in the Zucker diabetic fatty rat: effects of insulin resistance and of type 2 diabetes. AU - Wijekoon,Enoka P, AU - Skinner,Craig, AU - Brosnan,Margaret E, AU - Brosnan,John T, PY - 2004/9/25/pubmed PY - 2005/4/21/medline PY - 2004/9/25/entrez SP - 506 EP - 14 JF - Canadian journal of physiology and pharmacology JO - Can. J. Physiol. Pharmacol. VL - 82 IS - 7 N2 - We investigated amino acid metabolism in the Zucker diabetic fatty (ZDF Gmi fa/fa) rat during the prediabetic insulin-resistant stage and the frank type 2 diabetic stage. Amino acids were measured in plasma, liver, and skeletal muscle, and the ratios of plasma/liver and plasma/skeletal muscle were calculated. At the insulin-resistant stage, the plasma concentrations of the gluconeogenic amino acids aspartate, serine, glutamine, glycine, and histidine were decreased in the ZDF Gmi fa/fa rats, whereas taurine, alpha-aminoadipic acid, methionine, phenylalanine, tryptophan, and the 3 branched-chain amino acids were significantly increased. At the diabetic stage, a larger number of gluconeogenic amino acids had decreased plasma concentrations. The 3 branched-chain amino acids had elevated plasma concentrations. In the liver and the skeletal muscles, concentrations of many of the gluconeogenic amino acids were lower at both stages, whereas the levels of 1 or all of the branched-chain amino acids were elevated. These changes in amino acid concentrations are similar to changes seen in type 1 diabetes. It is evident that insulin resistance alone is capable of bringing about many of the changes in amino acid metabolism observed in type 2 diabetes. SN - 0008-4212 UR - https://www.unboundmedicine.com/medline/citation/15389298/Amino_acid_metabolism_in_the_Zucker_diabetic_fatty_rat:_effects_of_insulin_resistance_and_of_type_2_diabetes_ L2 - http://www.nrcresearchpress.com/doi/full/10.1139/y04-067?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -