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New epitope peptides derived from parathyroid hormone-related protein which have the capacity to induce prostate cancer-reactive cytotoxic T lymphocytes in HLA-A2+ prostate cancer patients.
Prostate. 2005 Feb 15; 62(3):233-42.P

Abstract

BACKGROUND

Parathyroid hormone-related protein (PTHrP) is produced by cancer cells and has been suggested to be responsible for malignancy-associated hypercalcemia and osteolysis after bone metatsases. Therefore, PTHrP is a promising target in the treatment of metastatic prostate cancer.

METHODS

Seven PTHrP-derived peptides were prepared based on the HLA-A2 binding motif. These peptide candidates were screened by their ability to induce peptide-specific cytotoxic T lymphocytes (CTLs), and their ability to be recognized by immunoglobulin G (IgG).

RESULTS

Both the PTHrP59-67 and PTHrP42-51 peptides were found to efficiently induce peptide-specific CTLs from peripheral blood mononuclear cells of HLA-A2+ prostate cancer patients with several HLA-A2 subtypes. These CTLs showed HLA-A2-restricted cytotoxicity toward prostate cancer cells. IgG reactive to the PTHrP42-51 peptide was frequently detected in prostate cancer patients.

CONCLUSIONS

These results indicate that these two new PTHrP peptides will be useful in the peptide-based immunotherapy of HLA-A2+ prostate cancer patients, especially those with bone metastases.

Authors+Show Affiliations

Department of Immunology, Kurume University School of Medicine, Kurume, Fukuoka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15389794

Citation

Yao, Akihisa, et al. "New Epitope Peptides Derived From Parathyroid Hormone-related Protein Which Have the Capacity to Induce Prostate Cancer-reactive Cytotoxic T Lymphocytes in HLA-A2+ Prostate Cancer Patients." The Prostate, vol. 62, no. 3, 2005, pp. 233-42.
Yao A, Harada M, Matsueda S, et al. New epitope peptides derived from parathyroid hormone-related protein which have the capacity to induce prostate cancer-reactive cytotoxic T lymphocytes in HLA-A2+ prostate cancer patients. Prostate. 2005;62(3):233-42.
Yao, A., Harada, M., Matsueda, S., Ishihara, Y., Shomura, H., Takao, Y., Noguchi, M., Matsuoka, K., Hara, I., Kamidono, S., & Itoh, K. (2005). New epitope peptides derived from parathyroid hormone-related protein which have the capacity to induce prostate cancer-reactive cytotoxic T lymphocytes in HLA-A2+ prostate cancer patients. The Prostate, 62(3), 233-42.
Yao A, et al. New Epitope Peptides Derived From Parathyroid Hormone-related Protein Which Have the Capacity to Induce Prostate Cancer-reactive Cytotoxic T Lymphocytes in HLA-A2+ Prostate Cancer Patients. Prostate. 2005 Feb 15;62(3):233-42. PubMed PMID: 15389794.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New epitope peptides derived from parathyroid hormone-related protein which have the capacity to induce prostate cancer-reactive cytotoxic T lymphocytes in HLA-A2+ prostate cancer patients. AU - Yao,Akihisa, AU - Harada,Mamoru, AU - Matsueda,Satoko, AU - Ishihara,Yuki, AU - Shomura,Hiroki, AU - Takao,Yukari, AU - Noguchi,Masanori, AU - Matsuoka,Kei, AU - Hara,Isao, AU - Kamidono,Sadao, AU - Itoh,Kyogo, PY - 2004/9/25/pubmed PY - 2005/2/23/medline PY - 2004/9/25/entrez SP - 233 EP - 42 JF - The Prostate JO - Prostate VL - 62 IS - 3 N2 - BACKGROUND: Parathyroid hormone-related protein (PTHrP) is produced by cancer cells and has been suggested to be responsible for malignancy-associated hypercalcemia and osteolysis after bone metatsases. Therefore, PTHrP is a promising target in the treatment of metastatic prostate cancer. METHODS: Seven PTHrP-derived peptides were prepared based on the HLA-A2 binding motif. These peptide candidates were screened by their ability to induce peptide-specific cytotoxic T lymphocytes (CTLs), and their ability to be recognized by immunoglobulin G (IgG). RESULTS: Both the PTHrP59-67 and PTHrP42-51 peptides were found to efficiently induce peptide-specific CTLs from peripheral blood mononuclear cells of HLA-A2+ prostate cancer patients with several HLA-A2 subtypes. These CTLs showed HLA-A2-restricted cytotoxicity toward prostate cancer cells. IgG reactive to the PTHrP42-51 peptide was frequently detected in prostate cancer patients. CONCLUSIONS: These results indicate that these two new PTHrP peptides will be useful in the peptide-based immunotherapy of HLA-A2+ prostate cancer patients, especially those with bone metastases. SN - 0270-4137 UR - https://www.unboundmedicine.com/medline/citation/15389794/New_epitope_peptides_derived_from_parathyroid_hormone_related_protein_which_have_the_capacity_to_induce_prostate_cancer_reactive_cytotoxic_T_lymphocytes_in_HLA_A2+_prostate_cancer_patients_ L2 - https://doi.org/10.1002/pros.20133 DB - PRIME DP - Unbound Medicine ER -